8CJ2
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![BU of 8cj2 by Molmil](/molmil-images/mine/8cj2) | Urea-based foldamer inhibitor c3u_5 chimera in complex with ASF1 histone chaperone | Descriptor: | GLYCEROL, Histone chaperone ASF1A, SULFATE ION, ... | Authors: | Perrin, M.E, Li, B, Mbianda, J, Ropars, V, Legrand, P, Douat, C, Ochsenbein, F, Guichard, G. | Deposit date: | 2023-02-11 | Release date: | 2023-07-05 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.127 Å) | Cite: | Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach. Chem.Commun.(Camb.), 59, 2023
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8CJ1
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![BU of 8cj1 by Molmil](/molmil-images/mine/8cj1) | Urea-based foldamer inhibitor c3u_3 chimera in complex with ASF1 histone chaperone | Descriptor: | Histone chaperone ASF1A, c3u_3 chimera inhibitor of histone chaperone ASF1 | Authors: | Perrin, M.E, Li, B, Mbianda, J, Ropars, V, Legrand, P, Douat, C, Ochsenbein, F, Guichard, G. | Deposit date: | 2023-02-11 | Release date: | 2023-07-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.564 Å) | Cite: | Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach. Chem.Commun.(Camb.), 59, 2023
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8CJ3
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![BU of 8cj3 by Molmil](/molmil-images/mine/8cj3) | Urea-based foldamer inhibitor c3u_7 chimera in complex with ASF1 histone chaperone | Descriptor: | Histone chaperone ASF1A, c3u_7 chimera inhibitor of histone chaperone ASF1 | Authors: | Perrin, M.E, Li, B, Mbianda, J, Ropars, V, Legrand, P, Douat, C, Ochsenbein, F, Guichard, G. | Deposit date: | 2023-02-11 | Release date: | 2023-07-05 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach. Chem.Commun.(Camb.), 59, 2023
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8PAY
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![BU of 8pay by Molmil](/molmil-images/mine/8pay) | Structure of the E.coli DNA polymerase sliding clamp with a covalently bound peptide 2. | Descriptor: | ACE-GLN-ALC-GLC-LEU-PHE, Beta sliding clamp, GLYCEROL, ... | Authors: | Compain, G, Monsarrat, C, Blagojevic, J, Brillet, K, Dumas, P, Hammann, P, Kuhn, L, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Burnouf, D, wagner, J, Guichard, G. | Deposit date: | 2023-06-08 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.21 Å) | Cite: | Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles to Target a Conserved His Residue of the Bacterial Sliding Clamp. Jacs Au, 4, 2024
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8BV1
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![BU of 8bv1 by Molmil](/molmil-images/mine/8bv1) | Peptide inhibitor P4 in complex with ASF1 histone chaperone | Descriptor: | GLYCEROL, Histone chaperone ASF1A, P4 peptide inhibitor of histone chaperone ASF1 | Authors: | Perrin, M.E, Li, B, Mbianda, J, Ropars, V, Legrand, P, Douat, C, Ochsenbein, F, Guichard, G. | Deposit date: | 2022-12-01 | Release date: | 2023-07-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.834 Å) | Cite: | Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach. Chem.Commun.(Camb.), 59, 2023
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8PAT
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![BU of 8pat by Molmil](/molmil-images/mine/8pat) | Structure of the E.coli DNA polymerase sliding clamp with a covalently bound peptide 3. | Descriptor: | ACE-GLN-ALC-GLX-LEU-PHE, Beta sliding clamp | Authors: | Compain, G, Monsarrat, C, Blagojevic, J, Brillet, K, Dumas, P, Hammann, P, Kuhn, L, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Burnouf, D, Guichard, G. | Deposit date: | 2023-06-08 | Release date: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles to Target a Conserved His Residue of the Bacterial Sliding Clamp. Jacs Au, 4, 2024
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4ZER
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![BU of 4zer by Molmil](/molmil-images/mine/4zer) | Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16s ribosomal RNA, 23s ribosomal RNA, ... | Authors: | Seefeldt, A.C, Nguyen, F, Antunes, S, Perebaskine, N, Graf, M, Arenz, S, Inampudi, K.K, Douat, C, Guichard, G, Wilson, D.N, Innis, C.A. | Deposit date: | 2015-04-20 | Release date: | 2015-05-20 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex. Nat.Struct.Mol.Biol., 22, 2015
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6HFA
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![BU of 6hfa by Molmil](/molmil-images/mine/6hfa) | Crystal structure of hDM2 in complex with a C-terminal triurea capped peptide chimera foldamer. | Descriptor: | E3 ubiquitin-protein ligase Mdm2, LM266, 1-[(2~{S})-2-azanyl-3-methyl-butyl]urea | Authors: | Buratto, J, Mauran, L, Goudreau, S, Fribourg, S, Guichard, G. | Deposit date: | 2018-08-21 | Release date: | 2020-07-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers. Angew.Chem.Int.Ed.Engl., 2020
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6XZK
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![BU of 6xzk by Molmil](/molmil-images/mine/6xzk) | Structure of zVDR LBD-Calcitriol in complex with chimera 13 | Descriptor: | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, ACETATE ION, GLU-ASN-ALA-UIA-URL-URY-URV-UZN-LYS, ... | Authors: | Buratto, J, Belorusova, A.Y, Rochel, N, Guichard, G. | Deposit date: | 2020-02-04 | Release date: | 2021-02-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers. Angew.Chem.Int.Ed.Engl., 60, 2021
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3Q4J
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![BU of 3q4j by Molmil](/molmil-images/mine/3q4j) | Structure of a small peptide ligand bound to E.coli DNA sliding clamp | Descriptor: | DNA polymerase III subunit beta, peptide ligand | Authors: | Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D. | Deposit date: | 2010-12-23 | Release date: | 2011-12-28 | Last modified: | 2013-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-based design of short peptide ligands binding onto the E. coli processivity ring. J.Med.Chem., 54, 2011
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3Q4K
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![BU of 3q4k by Molmil](/molmil-images/mine/3q4k) | Structure of a small peptide ligand bound to E.coli DNA sliding clamp | Descriptor: | DNA polymerase III subunit beta, peptide ligand | Authors: | Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D. | Deposit date: | 2010-12-23 | Release date: | 2011-12-28 | Last modified: | 2013-03-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-based design of short peptide ligands binding onto the E. coli processivity ring. J.Med.Chem., 54, 2011
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3Q4L
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![BU of 3q4l by Molmil](/molmil-images/mine/3q4l) | Structure of a small peptide ligand bound to E.coli DNA sliding clamp | Descriptor: | DNA polymerase III subunit beta, SODIUM ION, peptide ligand | Authors: | Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D. | Deposit date: | 2010-12-23 | Release date: | 2011-12-28 | Last modified: | 2013-03-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure-based design of short peptide ligands binding onto the E. coli processivity ring. J.Med.Chem., 54, 2011
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6XZJ
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![BU of 6xzj by Molmil](/molmil-images/mine/6xzj) | Structure of zVDR LBD-Calcitriol in complex with chimera 12 | Descriptor: | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, ACETATE ION, ARG-HIS-LYS-ILE-LEU-URR-UIL-URL-GLN, ... | Authors: | Buratto, J, Belorusova, A.Y, Rochel, N, Guichard, G. | Deposit date: | 2020-02-04 | Release date: | 2021-02-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers. Angew.Chem.Int.Ed.Engl., 60, 2021
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6XZH
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![BU of 6xzh by Molmil](/molmil-images/mine/6xzh) | Structure of zVDR LBD-Calcitriol in complex with chimera 10 | Descriptor: | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, ARG-HIS-LYS-ILE-URL-URK-URL-LEU-GLN, Vitamin D3 receptor A | Authors: | Buratto, J, Belorusova, A.Y, Rochel, N, Guichard, G. | Deposit date: | 2020-02-04 | Release date: | 2021-02-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.372 Å) | Cite: | Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers. Angew.Chem.Int.Ed.Engl., 60, 2021
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6XZI
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![BU of 6xzi by Molmil](/molmil-images/mine/6xzi) | Structure of zVDR LBD-calcitriol in complex with chimera 11 | Descriptor: | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, ACETATE ION, ARG-HIS-LYS-ILE-LEU-URK-UIL-URL, ... | Authors: | Buratto, J, Belorusova, A.Y, Rochel, N, Guichard, G. | Deposit date: | 2020-02-04 | Release date: | 2021-02-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers. Angew.Chem.Int.Ed.Engl., 60, 2021
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6XZV
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![BU of 6xzv by Molmil](/molmil-images/mine/6xzv) | Structure of zVDR LBD-Calcitriol in complex with chimera 18 | Descriptor: | 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, URA-UIA-URL-URY-URV-UZN-LYS, Vitamin D3 receptor A | Authors: | Buratto, J, Belorusova, A.Y, Rochel, N, Guichard, G. | Deposit date: | 2020-02-05 | Release date: | 2021-02-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers. Angew.Chem.Int.Ed.Engl., 60, 2021
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1CT6
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![BU of 1ct6 by Molmil](/molmil-images/mine/1ct6) | SOLUTION STRUCTURE OF CGGIRGERG IN CONTACT WITH THE MONOCLONAL ANTIBODY MAB 4X11, NMR, 11 STRUCTURES | Descriptor: | HISTONE H3 PEPTIDE | Authors: | Phan Chan Du, A, Petit, M.C, Guichard, G, Briand, J.P, Muller, S, Cung, M.T. | Deposit date: | 1999-08-19 | Release date: | 1999-09-02 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear Overhauser effect spectroscopy and molecular dynamics approach. Biochemistry, 40, 2001
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1CS9
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![BU of 1cs9 by Molmil](/molmil-images/mine/1cs9) | SOLUTION STRUCTURE OF CGGIRGERA IN CONTACT WITH THE MONOCLONAL ANTIBODY MAB 4X11, NMR, 7 STRUCTURES | Descriptor: | HISTONE H3 PEPTIDE | Authors: | Phan Chan Du, A, Petit, M.C, Guichard, G, Briand, J.P, Muller, S, Cung, M.T. | Deposit date: | 1999-08-18 | Release date: | 1999-09-02 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear Overhauser effect spectroscopy and molecular dynamics approach. Biochemistry, 40, 2001
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1CW8
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![BU of 1cw8 by Molmil](/molmil-images/mine/1cw8) | SOLUTION STRUCTURE OF THE ANALOGUE RETRO-INVERSO (mA-R)REGRIGGC IN CONTACT WITH THE MONOCLONAL ANTIBODY MAB 4X11, NMR, 6 STRUCTURES | Descriptor: | HISTONE H3, METHYLMALONIC ACID | Authors: | Phan Chan Du, A, Petit, M.C, Guichard, G, Briand, J.P, Muller, S, Cung, T. | Deposit date: | 1999-08-26 | Release date: | 1999-09-03 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear Overhauser effect spectroscopy and molecular dynamics approach. Biochemistry, 40, 2001
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1CVQ
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![BU of 1cvq by Molmil](/molmil-images/mine/1cvq) | SOLUTION STRUCTURE OF THE ANALOGUE RETRO-INVERSO MGREGRIGGC IN CONTACT WITH THE MONOCLONAL ANTIBODY MAB 4X11, NMR, 7 STRUCTURES | Descriptor: | HISTONE H3 | Authors: | Phan Chan Du, A, Petit, M.C, Guichard, G, Briand, J.P, Muller, S, Cung, M.T. | Deposit date: | 1999-08-24 | Release date: | 1999-09-02 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear Overhauser effect spectroscopy and molecular dynamics approach. Biochemistry, 40, 2001
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1CWZ
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![BU of 1cwz by Molmil](/molmil-images/mine/1cwz) | Solution structure of the analogue retro-inverso (MA-S)REGRIGGC in contact with the monoclonal antibody MAB 4X11, NMR, 7 structures | Descriptor: | HISTONE H3, METHYLMALONIC ACID | Authors: | Phan Chan Du, A, Petit, M.C, Guichard, G, Briand, J.P, Muller, S, Cung, M.T. | Deposit date: | 1999-08-27 | Release date: | 1999-09-03 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear Overhauser effect spectroscopy and molecular dynamics approach. Biochemistry, 40, 2001
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1BFW
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![BU of 1bfw by Molmil](/molmil-images/mine/1bfw) | RETRO-INVERSO ANALOGUE OF THE G-H LOOP OF VP1 IN FOOT-AND-MOUTH-DISEASE (FMD) VIRUS, NMR, 10 STRUCTURES | Descriptor: | VP1 PROTEIN | Authors: | Petit, M.C, Benkirane, N, Guichard, G, Phan Chan Du, A, Cung, M.T, Briand, J.P, Muller, S. | Deposit date: | 1998-05-22 | Release date: | 1999-01-13 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Solution structure of a retro-inverso peptide analogue mimicking the foot-and-mouth disease virus major antigenic site. Structural basis for its antigenic cross-reactivity with the parent peptide. J.Biol.Chem., 274, 1999
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6ZUF
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![BU of 6zuf by Molmil](/molmil-images/mine/6zuf) | Urea-based Foldamer Inhibitor chimera C2 in complex with ASF1 Histone chaperone | Descriptor: | C2 foldamer/peptide hybrid inhibitor of histone chaperone ASF1, GLYCEROL, Histone chaperone ASF1A, ... | Authors: | Bakail, M, Mbianda, J, Perrin, E.M, Guerois, R, Legrand, P, Traore, S, Douat, C, Guichard, G, Ochsenbein, F. | Deposit date: | 2020-07-22 | Release date: | 2021-06-09 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity. Sci Adv, 7, 2021
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7AZG
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![BU of 7azg by Molmil](/molmil-images/mine/7azg) | DNA polymerase sliding clamp from Escherichia coli with peptide 4 bound | Descriptor: | Beta sliding clamp, Peptide 4 | Authors: | Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y. | Deposit date: | 2020-11-16 | Release date: | 2021-12-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp. J.Med.Chem., 64, 2021
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7AZ5
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![BU of 7az5 by Molmil](/molmil-images/mine/7az5) | DNA polymerase sliding clamp from Escherichia coli with peptide 47 bound | Descriptor: | Beta sliding clamp, DI(HYDROXYETHYL)ETHER, Peptide 47, ... | Authors: | Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y. | Deposit date: | 2020-11-16 | Release date: | 2021-12-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp. J.Med.Chem., 64, 2021
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