4I0P
| HLA-DO in complex with HLA-DM | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, GLYCEROL, ... | Authors: | Guce, A.I, Mortimer, S.E, Stern, L.J. | Deposit date: | 2012-11-18 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism. Nat.Struct.Mol.Biol., 20, 2013
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4NCQ
| Crystal structure of NiSOD H1A mutant | Descriptor: | Superoxide dismutase [Ni] | Authors: | Guce, A.I, Garman, S.C. | Deposit date: | 2013-10-24 | Release date: | 2014-12-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Nickel superoxide dismutase: structural and functional roles of His1 and its H-bonding network. Biochemistry, 54, 2015
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3S5Y
| Pharmacological Chaperoning in Human alpha-Galactosidase | Descriptor: | (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2011-05-23 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.105 Å) | Cite: | The molecular basis of pharmacological chaperoning in human alpha-galactosidase Chem.Biol., 18, 2011
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3S5Z
| Pharmacological Chaperoning in Human alpha-Galactosidase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, GLYCEROL, ... | Authors: | Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2011-05-23 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | The molecular basis of pharmacological chaperoning in human alpha-galactosidase Chem.Biol., 18, 2011
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3HG4
| Human alpha-galactosidase catalytic mechanism 3. Covalent intermediate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2009-05-13 | Release date: | 2009-11-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Catalytic mechanism of human alpha-galactosidase. J.Biol.Chem., 285, 2010
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3HG5
| Human alpha-galactosidase catalytic mechanism 4. Product bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, Alpha-galactosidase A, ... | Authors: | Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2009-05-13 | Release date: | 2009-11-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Catalytic mechanism of human alpha-galactosidase. J.Biol.Chem., 285, 2010
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3HG2
| Human alpha-galactosidase catalytic mechanism 1. Empty active site | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, Alpha-galactosidase A, ... | Authors: | Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2009-05-13 | Release date: | 2009-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Catalytic mechanism of human alpha-galactosidase. J.Biol.Chem., 285, 2010
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3HG3
| Human alpha-galactosidase catalytic mechanism 2. Substrate bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... | Authors: | Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2009-05-13 | Release date: | 2009-11-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Catalytic mechanism of human alpha-galactosidase. J.Biol.Chem., 285, 2010
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3TV8
| Pharmacological Chaperoning in Human alpha-Galactosidase | Descriptor: | (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... | Authors: | Rogich, J.J, Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2011-09-19 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.639 Å) | Cite: | The molecular basis of pharmacological chaperoning in human alpha-galactosidase Chem.Biol., 18, 2011
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3LX9
| Interconversion of Human Lysosomal Enzyme Specificities | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... | Authors: | Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2010-02-25 | Release date: | 2010-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. J.Biol.Chem., 285, 2010
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3LXA
| Interconversion of Human Lysosomal Enzyme Specificities | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... | Authors: | Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2010-02-25 | Release date: | 2010-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.04 Å) | Cite: | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. J.Biol.Chem., 285, 2010
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3LXC
| Interconversion of Human Lysosomal Enzyme Specificities | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, GLYCEROL, ... | Authors: | Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2010-02-25 | Release date: | 2010-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. J.Biol.Chem., 285, 2010
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3LXB
| Interconversion of Human Lysosomal Enzyme Specificities | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... | Authors: | Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. | Deposit date: | 2010-02-25 | Release date: | 2010-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. J.Biol.Chem., 285, 2010
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3G4X
| Crystal Structure of NiSOD Y9F mutant | Descriptor: | CHLORIDE ION, NICKEL (II) ION, Superoxide dismutase [Ni] | Authors: | Garman, S.C, Guce, A.I, Herbst, R.W, Bryngelson, P.A, Cabelli, D.E, Higgins, K.A, Ryan, K.C, Maroney, M.J. | Deposit date: | 2009-02-04 | Release date: | 2009-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Role of conserved tyrosine residues in NiSOD catalysis: a case of convergent evolution Biochemistry, 48, 2009
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3G4Z
| Crystal Structure of NiSOD Y9F mutant at 1.9 A | Descriptor: | BROMIDE ION, NICKEL (II) ION, Superoxide dismutase [Ni] | Authors: | Garman, S.C, Guce, A.I, Herbst, R.W, Bryngelson, P.A, Cabelli, D.E, Higgins, K.A, Ryan, K.C, Maroney, M.J. | Deposit date: | 2009-02-04 | Release date: | 2009-04-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Role of conserved tyrosine residues in NiSOD catalysis: a case of convergent evolution Biochemistry, 48, 2009
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3G50
| Crystal Structure of NiSOD D3A mutant at 1.9 A | Descriptor: | NICKEL (II) ION, Superoxide dismutase [Ni] | Authors: | Garman, S.C, Guce, A.I, Herbst, R.W, Bryngelson, P.A, Cabelli, D.E, Higgins, K.A, Ryan, K.C, Maroney, M.J. | Deposit date: | 2009-02-04 | Release date: | 2009-04-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Role of conserved tyrosine residues in NiSOD catalysis: a case of convergent evolution Biochemistry, 48, 2009
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