3S5Z

Pharmacological Chaperoning in Human alpha-Galactosidase

Summary for 3S5Z

• Entry DOI: 10.2210/pdb3s5z/pdb
• Related: 1R46 1R47 3HG2 3HG3 3HG4 3HG5 3S5Y
• Descriptor: Alpha-galactosidase A, beta-D-xylopyranose-(1-2)-[alpha-D-mannopyranose-(1-3)][alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, pharmacological chaperone, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 95196.11

Authors

Guce, A.I.,Clark, N.E.,Garman, S.C. (deposition date: 2011-05-23, release date: 2012-01-04, Last modification date: 2023-09-13)

• Primary citation: Guce, A.I.,Clark, N.E.,Rogich, J.J.,Garman, S.C.; The molecular basis of pharmacological chaperoning in human alpha-galactosidase; Chem.Biol., 18:1521-1526, 2011; PubMed: 22195554; DOI: 10.1016/j.chembiol.2011.10.012

Experimental method

X-RAY DIFFRACTION (2.001 Å)