3S5Z

Pharmacological Chaperoning in Human alpha-Galactosidase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Alpha-galactosidase A	polymer	398	45394.5	2	UniProt (P06280) Pfam (PF16499) Pfam (PF17450) In PDB	Homo sapiens (human)	Alpha-D-galactosidase A, Alpha-D-galactoside galactohydrolase, Melibiase
2	C	beta-D-xylopyranose-(1-2)-[alpha-D-mannopyranose-(1-3)][alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1189.1	1	In PDB GlyTouCan (G26295XE)
3	D	alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G11971MR)
4	E	beta-D-xylopyranose-(1-2)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		880.8	1	In PDB GlyTouCan (G71469XA)
5	F	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G18638YB)
6	A, B	alpha-D-galactopyranose	non-polymer		180.2	2	Chemie (GLA)
7	A, B	beta-D-galactopyranose	non-polymer		180.2	2	Chemie (GAL)
8	B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
9	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
10		water	water		18.0	336	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	90789.1
Branched	Number of molecules	4
	Total formula weight	3373.1
Non-Polymers*	Number of molecules	6
	Total formula weight	1033.9
All*	Total formula weight	95196.1

*Water molecules are not included.