3TV8

Pharmacological Chaperoning in Human alpha-Galactosidase

Summary for 3TV8

Entry DOI	10.2210/pdb3tv8/pdb
Related	1R46 1R47 3HG2 3HG3 3S5Y 3S5Z
Descriptor	Alpha-galactosidase A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	pharmacological chaperone, (beta/alpha)8 barrel, carbohydrate-binding protein, glycosidase, glycoprotein, n-linked glycosylation, lysosome, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	96436.87
Authors	Rogich, J.J.,Guce, A.I.,Clark, N.E.,Garman, S.C. (deposition date: 2011-09-19, release date: 2012-01-04, Last modification date: 2023-09-13)
Primary citation	Guce, A.I.,Clark, N.E.,Rogich, J.J.,Garman, S.C. The molecular basis of pharmacological chaperoning in human alpha-galactosidase Chem.Biol., 18:1521-1526, 2011 Cited by PubMed: 22195554 DOI: 10.1016/j.chembiol.2011.10.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.639 Å)

Structure validation