3S5Y

Pharmacological Chaperoning in Human alpha-Galactosidase

Summary for 3S5Y

Entry DOI	10.2210/pdb3s5y/pdb
Related	1R46 1R47 3HG2 3HG3 3HG4 3HG5 3S5Z
Descriptor	Alpha-galactosidase A, 1,2-ETHANEDIOL, ACETIC ACID, ... (12 entities in total)
Functional Keywords	glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, pharmacological chaperone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	97829.15
Authors	Guce, A.I.,Clark, N.E.,Garman, S.C. (deposition date: 2011-05-23, release date: 2012-01-04, Last modification date: 2023-09-13)
Primary citation	Guce, A.I.,Clark, N.E.,Rogich, J.J.,Garman, S.C. The molecular basis of pharmacological chaperoning in human alpha-galactosidase Chem.Biol., 18:1521-1526, 2011 Cited by PubMed: 22195554 DOI: 10.1016/j.chembiol.2011.10.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.105 Å)

Structure validation