3K7L
 
 | | Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Atragin, CALCIUM ION, ... | | Authors: | Guan, H.H, Wu, W.G, Chen, C.J. | | Deposit date: | 2009-10-13 | | Release date: | 2010-03-02 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins
J.Struct.Biol., 169, 2010
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5XMJ
 | | Crystal structure of quinol:fumarate reductase from Desulfovibrio gigas | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | | Authors: | Guan, H.H, Hsieh, Y.C, Lin, P.R, Chen, C.J. | | Deposit date: | 2017-05-15 | | Release date: | 2018-06-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Structural insights into the electron/proton transfer pathways in the quinol:fumarate reductase from Desulfovibrio gigas.
Sci Rep, 8, 2018
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8X8G
 | | Crystal structure of EndoSz mutant D234M, from Streptococcus equi subsp. Zooepidemicus Sz105, in complex with oligosaccharide G2S2-oxazoline | | Descriptor: | 2-METHYL-4,5-DIHYDRO-(1,2-DIDEOXY-ALPHA-D-GLUCOPYRANOSO)[2,1-D]-1,3-OXAZOLE, CALCIUM ION, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose, ... | | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2023-11-27 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.
Jacs Au, 4, 2024
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5Z3Q
 | | Crystal Structure of a Soluble Fragment of Poliovirus 2C ATPase (2.55 Angstrom) | | Descriptor: | PHOSPHATE ION, PV-2C, ZINC ION | | Authors: | Guan, H, Tian, J, Zhang, C, Qin, B, Cui, S. | | Deposit date: | 2018-01-08 | | Release date: | 2018-09-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.545 Å) | | Cite: | Crystal structure of a soluble fragment of poliovirus 2CATPase
PLoS Pathog., 14, 2018
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5GRB
 | | Crystal structure of 2C helicase from enterovirus 71 (EV71) bound with ATPgammaS | | Descriptor: | EV71 2C ATPase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ZINC ION | | Authors: | Guan, H.X, Tian, J, Qin, B, Wojdyla, J, Wang, M.T, Cui, S. | | Deposit date: | 2016-08-09 | | Release date: | 2017-05-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.803 Å) | | Cite: | Crystal structure of 2C helicase from enterovirus 71
SCI ADV, 3, 2017
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5GQ1
 | | Crystal structure of 2C helicase from enterovirus 71 (EV71) | | Descriptor: | Genome polyprotein, PHOSPHATE ION, ZINC ION | | Authors: | Guan, H.X, Tian, J, Qin, B, Wojdyla, J, Wang, M.T, Cui, S. | | Deposit date: | 2016-08-05 | | Release date: | 2017-05-17 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.493 Å) | | Cite: | Crystal structure of 2C helicase from enterovirus 71
SCI ADV, 3, 2017
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5GNB
 | | Crystal Structure of the Receptor Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1 (HKU1 1A-CTD, 2.3 angstrom, native-SAD phasing) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Guan, H, Wojdyla, J.A, Wang, M, Cui, S. | | Deposit date: | 2016-07-20 | | Release date: | 2017-06-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1
Nat Commun, 8, 2017
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5KWB
 | | Crystal Structure of the Receptor Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1 (HKU1 1A-CTD, 1.9 angstrom, molecular replacement) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Spike glycoprotein, ... | | Authors: | Guan, H, Wojdyla, J.A, Wang, M, Cui, S. | | Deposit date: | 2016-07-17 | | Release date: | 2017-06-07 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1
Nat Commun, 8, 2017
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3K7N
 | | Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Guan, H.H, Huang, Y.W, Wu, W.G, Chen, C.J. | | Deposit date: | 2009-10-13 | | Release date: | 2010-03-02 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins
J.Struct.Biol., 169, 2010
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7CA0
 | | Crystal structure of dihydroorotase in complex with 5-fluoroorotic acid from Saccharomyces cerevisiae | | Descriptor: | 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, Dihydroorotase, ZINC ION | | Authors: | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | Deposit date: | 2020-06-08 | | Release date: | 2021-06-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Complexed Crystal Structure of Saccharomyces cerevisiae Dihydroorotase with Inhibitor 5-Fluoroorotate Reveals a New Binding Mode.
Bioinorg Chem Appl, 2021, 2021
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7CA1
 | | Crystal structure of dihydroorotase in complex with plumbagin from Saccharomyces cerevisiae | | Descriptor: | (2S)-2-hydroxybutanedioic acid, 5-hydroxy-2-methylnaphthalene-1,4-dione, Dihydroorotase, ... | | Authors: | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | Deposit date: | 2020-06-08 | | Release date: | 2021-06-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Plumbagin, a Natural Product with Potent Anticancer Activities, Binds to and Inhibits Dihydroorotase, a Key Enzyme in Pyrimidine Biosynthesis.
Int J Mol Sci, 22, 2021
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6L0I
 | | Crystal structure of dihydroorotase in complex with malate at pH6.5 from Saccharomyces cerevisiae | | Descriptor: | (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION | | Authors: | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | Deposit date: | 2019-09-26 | | Release date: | 2020-12-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil.
Biochem.Biophys.Res.Commun., 551, 2021
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6L0F
 | | Crystal structure of dihydroorotase in complex with 5-Aminouracil from Saccharomyces cerevisiae | | Descriptor: | 5-AMINO-1H-PYRIMIDINE-2,4-DIONE, Dihydroorotase, ZINC ION | | Authors: | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | Deposit date: | 2019-09-26 | | Release date: | 2020-12-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.26 Å) | | Cite: | Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil.
Biochem.Biophys.Res.Commun., 551, 2021
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6L0K
 | | Crystal structure of dihydroorotase in complex with malate at pH9 from Saccharomyces cerevisiae | | Descriptor: | (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION | | Authors: | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | Deposit date: | 2019-09-26 | | Release date: | 2020-12-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil.
Biochem.Biophys.Res.Commun., 551, 2021
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6L0H
 | | Crystal structure of dihydroorotase in complex with malate at pH7 from Saccharomyces cerevisiae | | Descriptor: | (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION | | Authors: | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | Deposit date: | 2019-09-26 | | Release date: | 2020-12-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.054 Å) | | Cite: | Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil.
Biochem.Biophys.Res.Commun., 551, 2021
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6L0J
 | | Crystal structure of Dihydroorotase in complex with malate at pH7.5 from Saccharomyces cerevisiae | | Descriptor: | (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION | | Authors: | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | Deposit date: | 2019-09-26 | | Release date: | 2020-12-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.933 Å) | | Cite: | Structural Analysis of Saccharomyces cerevisiae Dihydroorotase Reveals Molecular Insights into the Tetramerization Mechanism
Molecules, 2021
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6L0B
 | | Crystal structure of dihydroorotase in complex with fluorouracil from Saccharomyces cerevisiae | | Descriptor: | 5-FLUOROURACIL, Dihydroorotase, ZINC ION | | Authors: | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | Deposit date: | 2019-09-26 | | Release date: | 2020-12-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil.
Biochem.Biophys.Res.Commun., 551, 2021
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6L0G
 | | Crystal structure of dihydroorotase in complex with malate at pH6 from Saccharomyces cerevisiae | | Descriptor: | (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION | | Authors: | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | Deposit date: | 2019-09-26 | | Release date: | 2020-12-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.053 Å) | | Cite: | Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil.
Biochem.Biophys.Res.Commun., 551, 2021
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6L0A
 | | Crystal structure of dihydroorotase in complex with malate at pH7 from Saccharomyces cerevisiae | | Descriptor: | (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION | | Authors: | Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. | | Deposit date: | 2019-09-26 | | Release date: | 2020-12-02 | | Last modified: | 2021-12-15 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Structural Analysis of Saccharomyces cerevisiae Dihydroorotase Reveals Molecular Insights into the Tetramerization Mechanism
Molecules, 2021
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8W4M
 | | Crystal structure of open conformation of human immunoglobulin Fc in presence of EndoSz | | Descriptor: | Immunoglobulin gamma-1 heavy chain, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2023-08-24 | | Release date: | 2024-07-03 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.
Jacs Au, 4, 2024
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8W4L
 | | Crystal structure of closed conformation of human immunoglobulin Fc in presence of EndoSz | | Descriptor: | CHLORIDE ION, Immunoglobulin gamma-1 heavy chain, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2023-08-24 | | Release date: | 2024-07-03 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.
Jacs Au, 4, 2024
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8W4I
 | | Crystal structure of EndoSz mutant D234M in space group P21 | | Descriptor: | CALCIUM ION, glycoside hydrolase | | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2023-08-24 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.
Jacs Au, 4, 2024
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8W4G
 | | Crystal structure of EndoSz mutant D234M, from Streptococcus equi subsp. Zooepidemicus Sz105 | | Descriptor: | CALCIUM ION, glycoside hydrolase | | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2023-08-24 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.
Jacs Au, 4, 2024
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8W4N
 | | Crystal structure of EndoSz mutant D234M, in space group P21, in complex with oligosaccharide G2S1 | | Descriptor: | CALCIUM ION, Glycoside hydrolase, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Guan, H.H, Lin, C.C, Hsieh, Y.C, Chen, C.J. | | Deposit date: | 2023-08-24 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.
Jacs Au, 4, 2024
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5XNV
 | | Crystal structure of YEATS2 YEATS bound to H3K27ac peptide | | Descriptor: | ALA-ALA-ARG-ALY-SER-ALA-PRO-ALA, AMMONIUM ION, CHLORIDE ION, ... | | Authors: | Li, H.T, Guan, H.P, Zhao, D. | | Deposit date: | 2017-05-24 | | Release date: | 2017-11-01 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.696 Å) | | Cite: | YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.
Nat Commun, 8, 2017
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