3LH1
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![BU of 3lh1 by Molmil](/molmil-images/mine/3lh1) | Q191A mutant of the DegS-deltaPDZ | Descriptor: | Protease degS | Authors: | Sohn, J, Grant, R.A, Sauer, R.T. | Deposit date: | 2010-01-21 | Release date: | 2010-08-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.507 Å) | Cite: | Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J.Biol.Chem., 285, 2010
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3LGU
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![BU of 3lgu by Molmil](/molmil-images/mine/3lgu) | Y162A mutant of the DegS-deltaPDZ protease | Descriptor: | Protease degS | Authors: | Sohn, J, Grant, R.A, Sauer, R.T. | Deposit date: | 2010-01-21 | Release date: | 2010-08-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J.Biol.Chem., 285, 2010
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5W89
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![BU of 5w89 by Molmil](/molmil-images/mine/5w89) | Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-18 | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-18 | Authors: | Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E. | Deposit date: | 2017-06-21 | Release date: | 2018-01-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1PO2
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![BU of 1po2 by Molmil](/molmil-images/mine/1po2) | POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R77975, AN INHIBITOR OF VIRAL REPLICATION | Descriptor: | (METHYLPYRIDAZINE PIPERIDINE ETHYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, POLIOVIRUS TYPE 1 MAHONEY | Authors: | Hiremath, C.N, Filman, D.J, Grant, R.A, Hogle, J.M. | Deposit date: | 1997-01-08 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Ligand-induced conformational changes in poliovirus-antiviral drug complexes. Acta Crystallogr.,Sect.D, 53, 1997
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1PO1
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![BU of 1po1 by Molmil](/molmil-images/mine/1po1) | POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R80633, AN INHIBITOR OF VIRAL REPLICATION | Descriptor: | (METHYLPYRIDAZINE PIPERIDINE BUTYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, POLIOVIRUS TYPE 1 MAHONEY | Authors: | Hiremath, C.N, Filman, D.J, Grant, R.A, Hogle, J.M. | Deposit date: | 1997-01-08 | Release date: | 1997-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Ligand-induced conformational changes in poliovirus-antiviral drug complexes. Acta Crystallogr.,Sect.D, 53, 1997
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2RCE
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![BU of 2rce by Molmil](/molmil-images/mine/2rce) | |
2BVU
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![BU of 2bvu by Molmil](/molmil-images/mine/2bvu) | |
1PIV
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![BU of 1piv by Molmil](/molmil-images/mine/1piv) | BINDING OF THE ANTIVIRAL DRUG WIN51711 TO THE SABIN STRAIN OF TYPE 3 POLIOVIRUS: STRUCTURAL COMPARISON WITH DRUG BINDING IN RHINOVIRUS 14 | Descriptor: | 5-(7-(4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE, MYRISTIC ACID, POLIOVIRUS TYPE 3 (SUBUNIT VP1), ... | Authors: | Hiremath, C.N, Grant, R.A, Filman, D.J, Hogle, J.M. | Deposit date: | 1995-02-02 | Release date: | 1995-06-03 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Binding of the antiviral drug WIN51711 to the sabin strain of type 3 poliovirus: structural comparison with drug binding in rhinovirus 14. Acta Crystallogr.,Sect.D, 51, 1995
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2QGR
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![BU of 2qgr by Molmil](/molmil-images/mine/2qgr) | |
1YFN
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![BU of 1yfn by Molmil](/molmil-images/mine/1yfn) | Versatile modes of peptide recognition by the AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex | Descriptor: | Sigma-E factor negative regulatory protein, Stringent starvation protein B | Authors: | Levchenko, I, Grant, R.A, Flynn, J.M, Sauer, R.T, Baker, T.A. | Deposit date: | 2005-01-03 | Release date: | 2005-05-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Versatile modes of peptide recognition by the AAA+ adaptor protein SspB Nat.Struct.Mol.Biol., 12, 2005
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1ZSZ
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![BU of 1zsz by Molmil](/molmil-images/mine/1zsz) | Crystal structure of a computationally designed SspB heterodimer | Descriptor: | MAGNESIUM ION, Stringent starvation protein B homolog | Authors: | Bolon, D.N, Grant, R.A, Baker, T.A, Sauer, R.T. | Deposit date: | 2005-05-25 | Release date: | 2005-08-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Specificity versus stability in computational protein design. Proc.Natl.Acad.Sci.Usa, 102, 2005
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1U9P
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![BU of 1u9p by Molmil](/molmil-images/mine/1u9p) | Permuted single-chain Arc | Descriptor: | pArc | Authors: | Tabtiang, R.K, Cezairliyan, B.O, Grant, R.A, Cochrane, J.C, Sauer, R.T. | Deposit date: | 2004-08-10 | Release date: | 2005-02-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Consolidating critical binding determinants by noncyclic rearrangement of protein secondary structure Proc.Natl.Acad.Sci.Usa, 102, 2005
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6X0A
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![BU of 6x0a by Molmil](/molmil-images/mine/6x0a) | X-ray structure of a chimeric ParDE toxin-antitoxin complex from Mesorhizobium opportunistum | Descriptor: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Plasmid stabilization system, Putative addiction module antidote protein, ... | Authors: | Lite, T.L, Grant, R.A, Laub, M.T. | Deposit date: | 2020-05-15 | Release date: | 2020-11-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library. Elife, 9, 2020
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1OU8
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![BU of 1ou8 by Molmil](/molmil-images/mine/1ou8) | structure of an AAA+ protease delivery protein in complex with a peptide degradation tag | Descriptor: | MAGNESIUM ION, Stringent starvation protein B homolog, synthetic ssrA peptide | Authors: | Levchenko, I, Grant, R.A, Wah, D.A, Sauer, R.T, Baker, T.A. | Deposit date: | 2003-03-24 | Release date: | 2003-09-23 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag Mol.Cell, 12, 2003
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1OU9
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![BU of 1ou9 by Molmil](/molmil-images/mine/1ou9) | Structure of SspB, a AAA+ protease delivery protein | Descriptor: | CALCIUM ION, Stringent starvation protein B homolog | Authors: | Levchenko, I, Grant, R.A, Wah, D.A, Sauer, R.T, Baker, T.A. | Deposit date: | 2003-03-24 | Release date: | 2003-09-23 | Last modified: | 2014-04-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag Mol.Cell, 12, 2003
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1OUL
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![BU of 1oul by Molmil](/molmil-images/mine/1oul) | Structure of the AAA+ protease delivery protein SspB | Descriptor: | Stringent starvation protein B homolog | Authors: | Levchenko, I, Grant, R.A, Wah, D.A, Sauer, R.T, Baker, T.A. | Deposit date: | 2003-03-24 | Release date: | 2003-09-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag Mol.Cell, 12, 2003
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1TWB
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![BU of 1twb by Molmil](/molmil-images/mine/1twb) | SspB disulfide crosslinked to an ssrA degradation tag | Descriptor: | Stringent starvation protein B homolog, ssrA peptide | Authors: | Bolon, D.N, Grant, R.A, Baker, T.A, Sauer, R.T. | Deposit date: | 2004-06-30 | Release date: | 2004-11-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Nucleotide-Dependent Substrate Handoff from the SspB Adaptor to the AAA+ ClpXP Protease. Mol.Cell, 16, 2004
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1G2D
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![BU of 1g2d by Molmil](/molmil-images/mine/1g2d) | STRUCTURE OF A CYS2HIS2 ZINC FINGER/TATA BOX COMPLEX (CLONE #2) | Descriptor: | 5'-D(*GP*AP*CP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*AP*G)-3', 5'-D(*TP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*GP*TP*CP*C)-3', TATA BOX ZINC FINGER PROTEIN, ... | Authors: | Wolfe, S.A, Grant, R.A, Elrod-Erickson, M, Pabo, C.O. | Deposit date: | 2000-10-18 | Release date: | 2001-09-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes. Structure, 9, 2001
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1LLM
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![BU of 1llm by Molmil](/molmil-images/mine/1llm) | |
1F2I
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![BU of 1f2i by Molmil](/molmil-images/mine/1f2i) | COCRYSTAL STRUCTURE OF SELECTED ZINC FINGER DIMER BOUND TO DNA | Descriptor: | 5'-D(*AP*TP*GP*GP*GP*CP*GP*CP*GP*CP*CP*CP*AP*T)-3', FUSION OF N-TERMINAL 17-MER PEPTIDE EXTENSION TO ZIF12, ZINC ION | Authors: | Wang, B.S, Grant, R.A, Pabo, C.O. | Deposit date: | 2000-05-25 | Release date: | 2001-09-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Selected peptide extension contacts hydrophobic patch on neighboring zinc finger and mediates dimerization on DNA. Nat.Struct.Biol., 8, 2001
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1G2F
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![BU of 1g2f by Molmil](/molmil-images/mine/1g2f) | STRUCTURE OF A CYS2HIS2 ZINC FINGER/TATA BOX COMPLEX (TATAZF;CLONE #6) | Descriptor: | 5'-D(*GP*AP*CP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*AP*G)-3', 5'-D(*TP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*GP*TP*CP*C)-3', TATA BOX ZINC FINGER PROTEIN, ... | Authors: | Wolfe, S.A, Grant, R.A, Elrod-Erickson, M, Pabo, C.O. | Deposit date: | 2000-10-18 | Release date: | 2001-09-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes. Structure, 9, 2001
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1YWT
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![BU of 1ywt by Molmil](/molmil-images/mine/1ywt) | Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide | Descriptor: | 14-3-3 protein sigma, CALCIUM ION, synthetic optimal phosphopeptide (mode-1) | Authors: | Wilker, E.W, Grant, R.A, Artim, S.C, Yaffe, M.B. | Deposit date: | 2005-02-18 | Release date: | 2005-03-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A structural basis for 14-3-3sigma functional specificity. J.Biol.Chem., 280, 2005
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6VWP
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![BU of 6vwp by Molmil](/molmil-images/mine/6vwp) | Crystal structure of E. coli guanosine kinase in complex with ppGpp | Descriptor: | GUANOSINE, GUANOSINE-5',3'-TETRAPHOSPHATE, Inosine-guanosine kinase, ... | Authors: | Wang, B, Grant, R.A, Laub, M.T. | Deposit date: | 2020-02-20 | Release date: | 2020-10-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation. Mol.Cell, 80, 2020
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8TWP
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![BU of 8twp by Molmil](/molmil-images/mine/8twp) | Influenza A virus (A/Aichi/2/1968(H3N2) nucleoprotein mutant - 2-7 deleted, R416A | Descriptor: | Nucleoprotein | Authors: | Yoon, J, Zhang, Y.M, Grant, R.A, Shoulders, M.D. | Deposit date: | 2023-08-21 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The immune-evasive proline-283 substitution in influenza nucleoprotein increases aggregation propensity without altering the native structure. Sci Adv, 10, 2024
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2PQK
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![BU of 2pqk by Molmil](/molmil-images/mine/2pqk) | X-ray crystal structure of human Mcl-1 in complex with Bim BH3 | Descriptor: | Bim BH3 peptide, Induced myeloid leukemia cell differentiation protein Mcl-1, SODIUM ION, ... | Authors: | Bare, E, Grant, R.A, Keating, A.E. | Deposit date: | 2007-05-02 | Release date: | 2007-06-19 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
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