2PQK

X-ray crystal structure of human Mcl-1 in complex with Bim BH3

Summary for 2PQK

Entry DOI	10.2210/pdb2pqk/pdb
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, Bim BH3 peptide, ZINC ION, ... (5 entities in total)
Functional Keywords	bcl-2 family, bh3 domain, apoptosis
Biological source	Homo sapiens (human) More
Cellular location	Membrane ; Single-pass membrane protein : Q07820
Total number of polymer chains	2
Total formula weight	21542.35
Authors	Bare, E.,Grant, R.A.,Keating, A.E. (deposition date: 2007-05-02, release date: 2007-06-19, Last modification date: 2017-10-18)
Primary citation	Fire, E.,Gulla, S.V.,Grant, R.A.,Keating, A.E. Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19:507-519, 2010 Cited by PubMed: 20066663 DOI: 10.1002/pro.329 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation