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2PQK

X-ray crystal structure of human Mcl-1 in complex with Bim BH3

Functional Information from GO Data
ChainGOidnamespacecontents
A0042981biological_processregulation of apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 401
ChainResidue
AHOH53
AHOH93
AHIS252
AASP304

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 402
ChainResidue
AHIS224
AASP313
AGLU317
BGLU16

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 403
ChainResidue
BGLU9
BHOH416
BHOH421
AHIS320

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE NA A 404
ChainResidue
AGLU240
AASP241
AGLU292

Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues20
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFsDGvtNWGRIVTLIsFGA
ChainResidueDetails
AVAL253-ALA272

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV
ChainResidueDetails
ATRP305-VAL316

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN
ChainResidueDetails
AALA209-ASN223

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
ALYS194
ALYS197

226707

PDB entries from 2024-10-30

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