2PQK
X-ray crystal structure of human Mcl-1 in complex with Bim BH3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 158 | 17937.4 | 1 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (human) | Bcl-2- related protein EAT/mcl1, mcl1/EAT |
| 2 | B (B) | Bim BH3 peptide | polymer | 29 | 3385.8 | 1 | |||
| 3 | C, D, F (A, B) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | E (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
A: 172 - 327 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | - | cloning artifact |
| Ser 171 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21323.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 219.2 | |
| All* | Total formula weight | 21542.3 |
