1FTK
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1FTM
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6C13
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![BU of 6c13 by Molmil](/molmil-images/mine/6c13) | CryoEM structure of mouse PCDH15-4EC-LHFPL5 complex | Descriptor: | Protocadherin-15, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Gouaux, E, Ge, J, Elferich, J. | Deposit date: | 2018-01-03 | Release date: | 2018-08-15 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (11.33 Å) | Cite: | Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5. Elife, 7, 2018
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6C10
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![BU of 6c10 by Molmil](/molmil-images/mine/6c10) | Crystal structure of mouse PCDH15 EC11-EL | Descriptor: | Protocadherin-15, alpha-D-mannopyranose | Authors: | Gouaux, E, Elferich, J, Ge, J. | Deposit date: | 2018-01-03 | Release date: | 2018-08-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.399 Å) | Cite: | Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5. Elife, 7, 2018
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6C14
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4XP1
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![BU of 4xp1 by Molmil](/molmil-images/mine/4xp1) | X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine | Descriptor: | 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gouaux, E, Penmatsa, A, Wang, K. | Deposit date: | 2015-01-16 | Release date: | 2015-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XP5
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![BU of 4xp5 by Molmil](/molmil-images/mine/4xp5) | X-ray structure of Drosophila dopamine transporter bound to cocaine analogue-RTI55 | Descriptor: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Antibody fragment heavy chain-protein, 9D5-heavy chain, ... | Authors: | Gouaux, E, Penmatsa, A, Wang, K. | Deposit date: | 2015-01-16 | Release date: | 2015-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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2NWW
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![BU of 2nww by Molmil](/molmil-images/mine/2nww) | Crystal structure of GltPh in complex with TBOA | Descriptor: | (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID, 425aa long hypothetical proton glutamate symport protein | Authors: | Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K. | Deposit date: | 2006-11-16 | Release date: | 2007-02-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature, 445, 2007
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2NWX
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![BU of 2nwx by Molmil](/molmil-images/mine/2nwx) | Crystal structure of GltPh in complex with L-aspartate and sodium ions | Descriptor: | 425aa long hypothetical proton glutamate symport protein, ASPARTIC ACID, PALMITIC ACID, ... | Authors: | Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K. | Deposit date: | 2006-11-16 | Release date: | 2007-02-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature, 445, 2007
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2NWL
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![BU of 2nwl by Molmil](/molmil-images/mine/2nwl) | Crystal structure of GltPh in complex with L-Asp | Descriptor: | ASPARTIC ACID, PALMITIC ACID, glutamate symport protein | Authors: | Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K. | Deposit date: | 2006-11-15 | Release date: | 2007-02-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature, 445, 2007
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6NJM
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![BU of 6njm by Molmil](/molmil-images/mine/6njm) | Architecture and subunit arrangement of native AMPA receptors | Descriptor: | 15F1 Fab heavy chain, 15F1 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gouaux, E, Zhao, Y. | Deposit date: | 2019-01-03 | Release date: | 2019-04-24 | Last modified: | 2021-05-05 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM. Science, 364, 2019
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6NJL
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6NJN
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4TLL
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![BU of 4tll by Molmil](/molmil-images/mine/4tll) | Crystal structure of GluN1/GluN2B NMDA receptor, structure 1 | Descriptor: | 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... | Authors: | Gouaux, E, Lee, C.-H, Lu, W. | Deposit date: | 2014-05-30 | Release date: | 2014-07-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.59 Å) | Cite: | NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
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4TLM
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![BU of 4tlm by Molmil](/molmil-images/mine/4tlm) | Crystal structure of GluN1/GluN2B NMDA receptor, structure 2 | Descriptor: | 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... | Authors: | Gouaux, E, Lee, C.-H, Lu, W. | Deposit date: | 2014-05-30 | Release date: | 2014-07-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.77 Å) | Cite: | NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
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4M48
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![BU of 4m48 by Molmil](/molmil-images/mine/4m48) | X-ray structure of dopamine transporter elucidates antidepressant mechanism | Descriptor: | 9D5 antibody, heavy chain, light chain, ... | Authors: | Gouaux, E, Penmatsa, A, Wang, K. | Deposit date: | 2013-08-06 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature, 503, 2013
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8TKP
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![BU of 8tkp by Molmil](/molmil-images/mine/8tkp) | Structure of the C. elegans TMC-2 complex | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Clark, S, Jeong, H, Goehring, A, Posert, R, Gouaux, E. | Deposit date: | 2023-07-25 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction. Proc.Natl.Acad.Sci.USA, 121, 2024
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5WKV
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5WKY
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![BU of 5wky by Molmil](/molmil-images/mine/5wky) | Bromide sites in the structure of an acid sensing ion channel in a resting state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, ... | Authors: | Yoder, N, Gouaux, E. | Deposit date: | 2017-07-25 | Release date: | 2018-08-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography. PLoS ONE, 13, 2018
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3M4D
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3M2L
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3M4E
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1N0T
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![BU of 1n0t by Molmil](/molmil-images/mine/1n0t) | X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution. | Descriptor: | (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID, ACETATE ION, Glutamate receptor 2, ... | Authors: | Hogner, A, Greenwood, J.R, Liljefors, T, Lunn, M.-L, Egebjerg, J, Larsen, I.K, Gouaux, E, Kastrup, J.S. | Deposit date: | 2002-10-15 | Release date: | 2003-03-04 | Last modified: | 2017-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Competitive antagonism of AMPA receptors by ligands of
different classes: crystal structure of ATPO bound to the
GluR2 ligand-binding core, in comparison with DNQX. J.Med.Chem., 46, 2003
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6DZY
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![BU of 6dzy by Molmil](/molmil-images/mine/6dzy) | Cryo-EM structure of the ts2-active human serotonin transporter in complex with 15B8 Fab and 8B6 ScFv bound to ibogaine | Descriptor: | (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ... | Authors: | Coleman, J.A, Yang, D, Gouaux, E. | Deposit date: | 2018-07-05 | Release date: | 2019-04-24 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Nature, 569, 2019
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6DZV
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![BU of 6dzv by Molmil](/molmil-images/mine/6dzv) | Wild type human serotonin transporter in complex with 15B8 Fab bound to ibogaine in occluded conformation | Descriptor: | (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ... | Authors: | Coleman, J.A, Yang, D, Gouaux, E. | Deposit date: | 2018-07-05 | Release date: | 2019-04-24 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Nature, 569, 2019
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