1E2Q
 
 | | Human thymidylate kinase complexed with TP5A and a magnesium-ion | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ... | | 著者 | Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A. | | 登録日 | 2000-05-23 | | 公開日 | 2001-05-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
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1E2D
 | | Human thymidylate kinase complexed with thymidine monophosphate, adenosine diphosphate and a magnesium-ion | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ... | | 著者 | Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A. | | 登録日 | 2000-05-22 | | 公開日 | 2001-05-17 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
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1E2F
 | | Human thymidylate kinase complexed with thymidine monophosphate, adenosine diphosphate and a magnesium-ion | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A. | | 登録日 | 2000-05-22 | | 公開日 | 2001-05-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
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1E2G
 | | Human thymidylate kinase complexed with ADP, TDP and a magnesium-ion | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-DIPHOSPHATE, ... | | 著者 | Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A. | | 登録日 | 2000-05-22 | | 公開日 | 2001-05-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
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1GNQ
 | | X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP | | 分子名称: | C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION | | 著者 | Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S. | | 登録日 | 1995-05-11 | | 公開日 | 1995-07-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
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1GNR
 | | X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP | | 分子名称: | C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION | | 著者 | Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S. | | 登録日 | 1995-05-11 | | 公開日 | 1995-07-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
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1QRA
 | | STRUCTURE OF P21RAS IN COMPLEX WITH GTP AT 100 K | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1 | | 著者 | Scheidig, A, Burmester, C, Goody, R.S. | | 登録日 | 1999-06-12 | | 公開日 | 1999-11-05 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins.
Structure Fold.Des., 7, 1999
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5SZI
 | | Structure of human Rab8a in complex with the bMERB domain of Mical-cL | | 分子名称: | MAGNESIUM ION, MICAL C-terminal-like protein, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Rai, A, Oprisko, A, Campos, J, Fu, Y, Friese, T, Itzen, A, Goody, R.S, Mueller, M.P, Gazdag, E.M. | | 登録日 | 2016-08-14 | | 公開日 | 2016-08-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.
Elife, 5, 2016
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5SZH
 | | Structure of human Rab1b in complex with the bMERB domain of Mical-cL | | 分子名称: | MAGNESIUM ION, MICAL C-terminal-like protein, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Rai, A, Oprisko, A, Campos, J, Fu, Y, Friese, T, Goody, R.S, Mueller, M.P, Gazdag, E.M. | | 登録日 | 2016-08-14 | | 公開日 | 2016-08-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.
Elife, 5, 2016
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5SZG
 | | Structure of the bMERB domain of Mical-3 | | 分子名称: | DI(HYDROXYETHYL)ETHER, Protein-methionine sulfoxide oxidase MICAL3 | | 著者 | Rai, A, Oprisko, A, Campos, J, Fu, Y, Friese, T, Itzen, A, Goody, R.S, Gazdag, E.M, Mueller, M.P. | | 登録日 | 2016-08-14 | | 公開日 | 2016-08-24 | | 最終更新日 | 2017-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.
Elife, 5, 2016
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5SZK
 | | Structure of human N-terminally engineered Rab1b in complex with the bMERB domain of Mical-cL | | 分子名称: | MAGNESIUM ION, MICAL C-terminal-like protein, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Rai, A, Oprisko, A, Campos, J, Fu, Y, Friese, T, Itzen, A, Goody, R.S, Gazdag, E.M, Mueller, M.P. | | 登録日 | 2016-08-14 | | 公開日 | 2016-08-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.
Elife, 5, 2016
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5SZJ
 | | Structure of human Rab10 in complex with the bMERB domain of Mical-cL | | 分子名称: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, MICAL C-terminal-like protein, ... | | 著者 | Rai, A, Oprisko, A, Campos, J, Fu, Y, Friese, T, Itzen, A, Goody, R.S, Mueller, M.P, Gazdag, E.M. | | 登録日 | 2016-08-14 | | 公開日 | 2016-08-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | | 主引用文献 | bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.
Elife, 5, 2016
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4LI0
 | | Crystal structure of GDP-bound Rab8:GRAB | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide exchange factor for Rab-3A, Ras-related protein Rab-8A | | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | | 登録日 | 2013-07-01 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
J.Biol.Chem., 288, 2013
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4LHV
 | | Crystal structure of Rab8 in its inactive GDP-bound form | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-8A | | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | | 登録日 | 2013-07-01 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
J.Biol.Chem., 288, 2013
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4LHY
 | | Crystal structure of GDP-bound Rab8:Rabin8 | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Rab-3A-interacting protein, Ras-related protein Rab-8A, ... | | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | | 登録日 | 2013-07-01 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
J.Biol.Chem., 288, 2013
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4LHZ
 | | Crystal structure of GTP-bound Rab8:Rabin8 | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Rab-3A-interacting protein, Ras-related protein Rab-8A | | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | | 登録日 | 2013-07-01 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
J.Biol.Chem., 288, 2013
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4LHW
 | | Crystal structure of Rab8 in its active GppNHp-bound form | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | | 登録日 | 2013-07-01 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
J.Biol.Chem., 288, 2013
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4LHX
 | | Crystal structure of nucleotide-free Rab8:Rabin8 | | 分子名称: | Rab-3A-interacting protein, Ras-related protein Rab-8A, SULFATE ION | | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | | 登録日 | 2013-07-01 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
J.Biol.Chem., 288, 2013
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3JZA
 | | Crystal structure of human Rab1b in complex with the GEF domain of DrrA/SidM from Legionella pneumophila | | 分子名称: | PHOSPHATE ION, Ras-related protein Rab-1B, Uncharacterized protein DrrA | | 著者 | Schoebel, S, Oesterlin, L.K, Blankenfeldt, W, Goody, R.S, Itzen, A. | | 登録日 | 2009-09-23 | | 公開日 | 2010-01-19 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity.
Mol.Cell, 36, 2009
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3JZ9
 | | Crystal structure of the GEF domain of DrrA/SidM from Legionella pneumophila | | 分子名称: | Uncharacterized protein DrrA | | 著者 | Schoebel, S, Oesterlin, L.K, Blankenfeldt, W, Goody, R.S, Itzen, A. | | 登録日 | 2009-09-23 | | 公開日 | 2010-01-19 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity.
Mol.Cell, 36, 2009
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3HXD
 | | Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 9) | | 分子名称: | CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... | | 著者 | Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. | | 登録日 | 2009-06-20 | | 公開日 | 2009-09-08 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors
J.Med.Chem., 52, 2009
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3HXE
 | | Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 37) | | 分子名称: | CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... | | 著者 | Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. | | 登録日 | 2009-06-20 | | 公開日 | 2009-09-08 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors
J.Med.Chem., 52, 2009
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4OOJ
 | | Crystal structure of the N-terminal domain of the Legionella pneumophila protein SidC at 2.4A resolution | | 分子名称: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, SidC, ... | | 著者 | Gazdag, E.M, Shoebel, S, Shkumatov, A.V, Goody, R.S, Itzen, A. | | 登録日 | 2014-02-03 | | 公開日 | 2014-02-26 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The structure of the N-terminal domain of the Legionella protein SidC
J.Struct.Biol., 186, 2014
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3HXF
 | | Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 32) | | 分子名称: | CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... | | 著者 | Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. | | 登録日 | 2009-06-20 | | 公開日 | 2009-09-08 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors
J.Med.Chem., 52, 2009
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3HXB
 | | Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 6) | | 分子名称: | Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, N-[(benzyloxy)carbonyl]-D-tyrosyl-L-phenylalanyl-L-tyrosine, ... | | 著者 | Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. | | 登録日 | 2009-06-20 | | 公開日 | 2009-09-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors
J.Med.Chem., 52, 2009
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