8TQP
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![BU of 8tqp by Molmil](/molmil-images/mine/8tqp) | HIV-CA Disulfide linked Hexamer bound to Quinazolin-4-one Scaffold inhibitor | 分子名称: | 2-[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]-N-{(1R)-2-(3,5-difluorophenyl)-1-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}acetamide, Gag polyprotein | 著者 | Goldstone, D.C, Barnett, M.J, Taka, J.R.H. | 登録日 | 2023-08-08 | 公開日 | 2023-12-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators. J.Med.Chem., 66, 2023
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8TOV
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![BU of 8tov by Molmil](/molmil-images/mine/8tov) | HIV-CA Disulfide linked Hexamer bound to Quinazolin-4-one Scaffold inhibitor | 分子名称: | 2-[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]-N-[(1R)-2-(3,5-difluorophenyl)-1-{3-[4-(morpholine-4-sulfonyl)phenyl]-4-oxo-3,4-dihydroquinazolin-2-yl}ethyl]acetamide, Matrix protein p17 | 著者 | Goldstone, D.C, Barnett, M.J, Taka, J.R.H. | 登録日 | 2023-08-04 | 公開日 | 2023-12-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators. J.Med.Chem., 66, 2023
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6SA9
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![BU of 6sa9 by Molmil](/molmil-images/mine/6sa9) | |
3U1N
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![BU of 3u1n by Molmil](/molmil-images/mine/3u1n) | Structure of the catalytic core of human SAMHD1 | 分子名称: | PHOSPHATE ION, SAM domain and HD domain-containing protein 1, ZINC ION | 著者 | Goldstone, D.C, Ennis-Adeniran, V, Walker, P.A, Haire, L.F, Webb, M, Taylor, I.A. | 登録日 | 2011-09-30 | 公開日 | 2011-11-16 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase Nature, 480, 2011
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5CYY
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![BU of 5cyy by Molmil](/molmil-images/mine/5cyy) | |
2Y4Z
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![BU of 2y4z by Molmil](/molmil-images/mine/2y4z) | Structure of the amino-terminal capsid restriction escape mutation N- MLV L10W | 分子名称: | CAPSID PROTEIN P30, GLYCEROL | 著者 | Goldstone, D.C, Holden-Dye, K, Ohkura, S, Stoye, J.P, Taylor, I.A. | 登録日 | 2011-01-11 | 公開日 | 2011-11-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Novel Escape Mutants Suggest an Extensive Trim5Alpha Binding Site Spanning the Entire Outer Surface of the Murine Leukemia Virus Capsid Protein. Plos Pathog., 7, 2011
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2XGY
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![BU of 2xgy by Molmil](/molmil-images/mine/2xgy) | Complex of Rabbit Endogenous Lentivirus (RELIK)Capsid with Cyclophilin A | 分子名称: | GLYCEROL, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, RELIK CAPSID N-TERMINAL DOMAIN | 著者 | Goldstone, D.C, Robertson, L.E, Haire, L.F, Stoye, J.P, Taylor, I.A. | 登録日 | 2010-06-08 | 公開日 | 2010-09-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and Functional Analysis of Prehistoric Lentiviruses Uncovers an Ancient Molecular Interface. Cell Host Microbe, 8, 2010
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2WTM
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![BU of 2wtm by Molmil](/molmil-images/mine/2wtm) | Est1E from Butyrivibrio proteoclasticus | 分子名称: | EST1E, GLYCEROL, PHOSPHATE ION | 著者 | Goldstone, D.C, Arcus, V.L. | 登録日 | 2009-09-17 | 公開日 | 2010-01-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural and Functional Characterization of a Promiscuous Feruloyl Esterase (Est1E) from the Rumen Bacterium Butyrivibrio Proteoclasticus. Proteins, 78, 2010
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2WTN
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2XGV
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![BU of 2xgv by Molmil](/molmil-images/mine/2xgv) | Structure of the N-terminal domain of capsid protein from Rabbit Endogenous Lentivirus (RELIK) | 分子名称: | PSIV CAPSID N-TERMINAL DOMAIN | 著者 | Goldstone, D.C, Robertson, L.E, Haire, L.F, Stoye, J.P, Taylor, I.A. | 登録日 | 2010-06-07 | 公開日 | 2010-09-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and Functional Analysis of Prehistoric Lentiviruses Uncovers an Ancient Molecular Interface. Cell Host Microbe, 8, 2010
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2XGU
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![BU of 2xgu by Molmil](/molmil-images/mine/2xgu) | Structure of the N-terminal domain of capsid protein from Rabbit Endogenous Lentivirus (RELIK) | 分子名称: | ACETATE ION, RELIK CAPSID N-TERMINAL DOMAIN | 著者 | Goldstone, D.C, Taylor, I.A, Robertson, L.E, Haire, L.F, Stoye, J.P. | 登録日 | 2010-06-07 | 公開日 | 2010-09-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.502 Å) | 主引用文献 | Structural and Functional Analysis of Prehistoric Lentiviruses Uncovers an Ancient Molecular Interface. Cell Host Microbe, 8, 2010
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6YXE
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![BU of 6yxe by Molmil](/molmil-images/mine/6yxe) | |
5JCG
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![BU of 5jcg by Molmil](/molmil-images/mine/5jcg) | |
5W9A
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![BU of 5w9a by Molmil](/molmil-images/mine/5w9a) | The structure of the Trim5alpha Bbox- coiled coil in complex LC3B | 分子名称: | Microtubule-associated proteins 1A/1B light chain 3B, Tripartite motif-containing protein 5, ZINC ION | 著者 | Keown, J.R, Goldstone, D.C. | 登録日 | 2017-06-22 | 公開日 | 2018-10-10 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5 alpha and mammalian autophagy-related ATG8 proteins. J. Biol. Chem., 293, 2018
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6WRM
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![BU of 6wrm by Molmil](/molmil-images/mine/6wrm) | The interaction of chlorido(1,5-cyclooctadiene)([4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1,3-dimethyl-1H-imidazol-3-ide])rhodium(I) with HEWL after 1 month | 分子名称: | (4-{2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}-1,3-dimethyl-2,3-dihydro-1H-imidazol-2-yl)rhodium, CHLORIDE ION, Lysozyme, ... | 著者 | Sullivan, M.P, John, M, Hartinger, C.G, Goldstone, D.C. | 登録日 | 2020-04-29 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | A Combined Spectroscopic and Protein Crystallography Study Reveals Protein Interactions of Rh I (NHC) Complexes at the Molecular Level. Inorg.Chem., 59, 2020
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6WRL
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![BU of 6wrl by Molmil](/molmil-images/mine/6wrl) | The interaction of chlorido(1,5-cyclooctadiene)([4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1,3-dimethyl-1H-imidazol-3-ide])rhodium(I) with HEWL after 1 week | 分子名称: | ACETATE ION, Lysozyme, Rhodium, ... | 著者 | Sullivan, M.P, John, M, Hartinger, C.G, Goldstone, D.C. | 登録日 | 2020-04-29 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | A Combined Spectroscopic and Protein Crystallography Study Reveals Protein Interactions of Rh I (NHC) Complexes at the Molecular Level. Inorg.Chem., 59, 2020
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6WX5
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![BU of 6wx5 by Molmil](/molmil-images/mine/6wx5) | Adducts formed after 3 weeks in the reaction of chlorido[chlorido(2,2'-((2-([2,2':6',2''-Terpyridin]-4'-yloxy)ethyl)azanediyl)bis(ethan-1-ol))platinum(II)] with HEWL | 分子名称: | ACETATE ION, Lysozyme, PLATINUM (II) ION, ... | 著者 | Sullivan, M.P, Hartinger, C.G, Goldstone, D.C. | 登録日 | 2020-05-09 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Mustards-Derived Terpyridine-Platinum Complexes as Anticancer Agents: DNA Alkylation vs Coordination. Inorg.Chem., 60, 2021
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6WGO
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![BU of 6wgo by Molmil](/molmil-images/mine/6wgo) | The interaction of dichlorido(3-(anthracen-9-ylmethyl)-1-methylimidazol-2-ylidene)(eta6-p-cymene)ruthenium(II) with HEWL after 1 week | 分子名称: | ACETATE ION, Lysozyme, SODIUM ION, ... | 著者 | Sullivan, M.P, Hartinger, C.G, Goldstone, D.C. | 登録日 | 2020-04-06 | 公開日 | 2021-10-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Anthracenyl Functionalization of Half-Sandwich Carbene Complexes: In Vitro Anticancer Activity and Reactions with Biomolecules. Inorg.Chem., 60, 2021
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4TN3
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![BU of 4tn3 by Molmil](/molmil-images/mine/4tn3) | Structure of the BBox-Coiled-coil region of Rhesus Trim5alpha | 分子名称: | TRIM5/cyclophilin A fusion protein/T4 Lysozyme chimera, ZINC ION | 著者 | Kirkpatrick, J.J, Stoye, J.P, Taylor, I.A, Goldstone, D.C. | 登録日 | 2014-06-03 | 公開日 | 2014-07-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.1989 Å) | 主引用文献 | Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice. Proc.Natl.Acad.Sci.USA, 111, 2014
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8F22
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![BU of 8f22 by Molmil](/molmil-images/mine/8f22) | |
8EV4
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![BU of 8ev4 by Molmil](/molmil-images/mine/8ev4) | NlpC B3 - Trichomonas Vaginalis | 分子名称: | Clan CA, family C40, NlpC/P60 superfamily cysteine peptidase | 著者 | Barnett, M.J, Goldstone, D.C. | 登録日 | 2022-10-19 | 公開日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli. Plos Pathog., 19, 2023
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8EV5
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![BU of 8ev5 by Molmil](/molmil-images/mine/8ev5) | |
4JNH
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![BU of 4jnh by Molmil](/molmil-images/mine/4jnh) | |
4JMR
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![BU of 4jmr by Molmil](/molmil-images/mine/4jmr) | A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral Matrix and Capsid | 分子名称: | Env protein, Gag protein | 著者 | Taylor, I.A, Goldstone, D.C, Flower, T.G, Ball, N.J. | 登録日 | 2013-03-14 | 公開日 | 2013-05-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A Unique Spumavirus Gag N-terminal Domain with Functional Properties of Orthoretroviral Matrix and Capsid. Plos Pathog., 9, 2013
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5K3Q
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![BU of 5k3q by Molmil](/molmil-images/mine/5k3q) | Rhesus macaques Trim5alpha Bbox2 domain | 分子名称: | NITRATE ION, Tripartite motif-containing protein 5,Tripartite motif-containing protein 5, ZINC ION | 著者 | Keown, J.K, Goldstone, D.C. | 登録日 | 2016-05-19 | 公開日 | 2016-07-20 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of the Trim5 alpha Bbox2 domain from rhesus macaques describes a plastic oligomerisation interface. J.Struct.Biol., 195, 2016
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