5TPG
 
 | | Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors | | 分子名称: | (3S)-8-(2-amino-6-{(1R)-1-[5-chloro-3'-(methylsulfonyl)[1,1'-biphenyl]-2-yl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETONITRILE, ... | | 著者 | Stein, A.J, Goldberg, D.R, De Lombaert, S, Holt, M.C. | | 登録日 | 2016-10-20 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
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1ASH
 | | THE STRUCTURE OF ASCARIS HEMOGLOBIN DOMAIN I AT 2.2 ANGSTROMS RESOLUTION: MOLECULAR FEATURES OF OXYGEN AVIDITY | | 分子名称: | HEMOGLOBIN (OXY), OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Yang, J, Mathews, F.S, Kloek, A.P, Goldberg, D.E. | | 登録日 | 1995-01-06 | | 公開日 | 1995-02-27 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | The structure of Ascaris hemoglobin domain I at 2.2 A resolution: molecular features of oxygen avidity.
Proc.Natl.Acad.Sci.USA, 92, 1995
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7MYV
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7MRW
 | | Native RhopH complex of the malaria parasite Plasmodium falciparum | | 分子名称: | Cytoadherence linked asexual protein 3.1, High molecular weight rhoptry protein 2, High molecular weight rhoptry protein 3 | | 著者 | Ho, C.M, Jih, J, Lai, M, Li, X.R, Goldberg, D.E, Beck, J.R, Zhou, Z.H. | | 登録日 | 2021-05-10 | | 公開日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition.
Proc.Natl.Acad.Sci.USA, 118, 2021
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5J6D
 | | Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-[(N-{[2-(3-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl}carbamimidoyl)carbamoyl]-L-phenylalanine, FE (III) ION, ... | | 著者 | Stein, A.J, Goldberg, D.R, De Lombaert, S. | | 登録日 | 2016-04-04 | | 公開日 | 2016-05-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
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3S5K
 | | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum | | 分子名称: | Falcilysin, ZINC ION | | 著者 | Morgunova, E, Ponpuak, M, Istvan, E, Popov, A, Goldberg, D, Eneqvist, T. | | 登録日 | 2011-05-23 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structures of falcilysin, a M16 metalloprotease from
the malaria parasite Plasmodium falciparum
To be Published
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2PZY
 | | Structure of MK2 Complexed with Compound 76 | | 分子名称: | (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE, MAP kinase-activated protein kinase 2, STAUROSPORINE | | 著者 | White, A, Wu, J.P, Wang, J, Abeywardane, A, Andersen, D, Emmanuel, M, Gautschi, E, Goldberg, D.R, Kashem, M.A, Lukas, S, Mao, W, Martin, L, Morwick, T, Moss, N, Pargellis, C, Patel, U.R, Patnaude, L, Peet, G.W, Skow, D, Snow, R.J, Ward, Y, Werneburg, B. | | 登録日 | 2007-05-18 | | 公開日 | 2007-07-31 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The discovery of carboline analogs as potent MAPKAP-K2 inhibitors
Bioorg.Med.Chem.Lett., 17, 2007
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5L01
 | | Tryptophan 5-hydroxylase in complex with inhibitor (3~{S})-8-[2-azanyl-6-[(1~{R})-1-(4-chloranyl-2-phenyl-phenyl)-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3-carboxylic acid | | 分子名称: | (3~{S})-8-[2-azanyl-6-[(1~{R})-1-(4-chloranyl-2-phenyl-phenyl)-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3-carboxylic acid, FE (III) ION, Tryptophan 5-hydroxylase 1 | | 著者 | Stein, A.J, Goldberg, D.R, De Lombaert, S, Holt, M.C. | | 登録日 | 2016-07-26 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
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3S5M
 | | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum | | 分子名称: | Falcilysin, MAGNESIUM ION, ZINC ION | | 著者 | Morgunova, E, Ponpuak, M, Istvan, E, Popov, A, Goldberg, D, Eneqvist, T. | | 登録日 | 2011-05-23 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Crystal structures of falcilysin, a M16 metalloprotease from
the malaria parasite Plasmodium falciparum
To be Published
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1SME
 | | PLASMEPSIN II, A HEMOGLOBIN-DEGRADING ENZYME FROM PLASMODIUM FALCIPARUM, IN COMPLEX WITH PEPSTATIN A | | 分子名称: | PLASMEPSIN II, Pepstatin | | 著者 | Silva, A.M, Lee, A.Y, Gulnik, S.V, Goldberg, D.E, Erickson, J.W. | | 登録日 | 1996-06-11 | | 公開日 | 1997-01-11 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.
Proc.Natl.Acad.Sci.USA, 93, 1996
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3S5H
 | | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum | | 分子名称: | COBALT (II) ION, Falcilysin | | 著者 | Morgunova, E, Ponpuak, M, Istvan, E, Popov, A, Goldberg, D, Eneqvist, T. | | 登録日 | 2011-05-23 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.603 Å) | | 主引用文献 | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum
To be Published
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3S5I
 | | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum | | 分子名称: | Falcilysin | | 著者 | Morgunova, E, Ponpuak, M, Istvan, E, Popov, A, Goldberg, D, Eneqvist, T. | | 登録日 | 2011-05-23 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.743 Å) | | 主引用文献 | Crystal structures of falcilysin, a M16 metalloprotease from
the malaria parasite Plasmodium falciparum
To be Published
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