5L01
Tryptophan 5-hydroxylase in complex with inhibitor (3~{S})-8-[2-azanyl-6-[(1~{R})-1-(4-chloranyl-2-phenyl-phenyl)-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3-carboxylic acid
Summary for 5L01
Entry DOI | 10.2210/pdb5l01/pdb |
Related | 5J6D |
Descriptor | Tryptophan 5-hydroxylase 1, FE (III) ION, (3~{S})-8-[2-azanyl-6-[(1~{R})-1-(4-chloranyl-2-phenyl-phenyl)-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3-carboxylic acid, ... (4 entities in total) |
Functional Keywords | tph1, iron, acyl, quanidine, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 51678.94 |
Authors | Stein, A.J.,Goldberg, D.R.,De Lombaert, S.,Holt, M.C. (deposition date: 2016-07-26, release date: 2017-01-25, Last modification date: 2023-10-04) |
Primary citation | Goldberg, D.R.,De Lombaert, S.,Aiello, R.,Bourassa, P.,Barucci, N.,Zhang, Q.,Paralkar, V.,Stein, A.J.,Holt, M.,Valentine, J.,Zavadoski, W. Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg. Med. Chem. Lett., 27:413-419, 2017 Cited by PubMed: 28041831DOI: 10.1016/j.bmcl.2016.12.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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