5L01
Tryptophan 5-hydroxylase in complex with inhibitor (3~{S})-8-[2-azanyl-6-[(1~{R})-1-(4-chloranyl-2-phenyl-phenyl)-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3-carboxylic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002576 | biological_process | platelet degranulation |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004510 | molecular_function | tryptophan 5-monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0009072 | biological_process | aromatic amino acid metabolic process |
| A | 0016714 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
| A | 0030279 | biological_process | negative regulation of ossification |
| A | 0035902 | biological_process | response to immobilization stress |
| A | 0042427 | biological_process | serotonin biosynthetic process |
| A | 0043005 | cellular_component | neuron projection |
| A | 0045600 | biological_process | positive regulation of fat cell differentiation |
| A | 0046849 | biological_process | bone remodeling |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0060749 | biological_process | mammary gland alveolus development |
| A | 1900046 | biological_process | regulation of hemostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue FE A 501 |
| Chain | Residue |
| A | HIS272 |
| A | HIS277 |
| A | GLU317 |
| A | HOH627 |
| A | HOH655 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue 6Z4 A 502 |
| Chain | Residue |
| A | PRO266 |
| A | GLU267 |
| A | PRO268 |
| A | HIS272 |
| A | ALA309 |
| A | PHE313 |
| A | GLU317 |
| A | GLY333 |
| A | SER336 |
| A | SER337 |
| A | CYS364 |
| A | ILE366 |
| A | HOH629 |
| A | HOH655 |
| A | LEU236 |
| A | ARG257 |
| A | TYR264 |
| A | THR265 |
Functional Information from PROSITE/UniProt
| site_id | PS00367 |
| Number of Residues | 12 |
| Details | BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDtcHELLGHVP |
| Chain | Residue | Details |
| A | PRO268-PRO279 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P70080 |
| Chain | Residue | Details |
| A | SER336 | |
| A | ILE366 | |
| A | TYR235 | |
| A | ARG257 | |
| A | THR265 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12379098, ECO:0007744|PDB:1MLW |
| Chain | Residue | Details |
| A | HIS272 | |
| A | HIS277 | |
| A | GLU317 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000255 |
| Chain | Residue | Details |
| A | SER58 |
