1A2Q
 
 | | SUBTILISIN BPN' MUTANT 7186 | | Descriptor: | ACETONE, CALCIUM ION, SUBTILISIN BPN' | | Authors: | Gilliland, G.L, Whitlow, M, Howard, A.J. | | Deposit date: | 1998-01-08 | | Release date: | 1998-04-29 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding.
Biochemistry, 28, 1989
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2HHD
 | | OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA-CHAINS IN HUMAN AND BOVINE HEMOGLOBIN | | Descriptor: | HEMOGLOBIN (DEOXY) (ALPHA CHAIN), HEMOGLOBIN (DEOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Gilliland, G.L, Pechik, I, Fronticelli, C, Ji, X. | | Deposit date: | 1994-09-29 | | Release date: | 1995-01-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystallographic, molecular modeling, and biophysical characterization of the valine beta 67 (E11)-->threonine variant of hemoglobin.
Biochemistry, 35, 1996
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2HHE
 | | OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA CHAINS IN HUMAN AND BOVINE HEMOGLOBIN | | Descriptor: | HEMOGLOBIN (DEOXY) (ALPHA CHAIN), HEMOGLOBIN (DEOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Gilliland, G.L, Pechik, I, Fronticelli, C, Ji, X. | | Deposit date: | 1994-09-29 | | Release date: | 1995-01-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Chloride ion independence of the Bohr effect in a mutant human hemoglobin beta (V1M+H2deleted).
J.Biol.Chem., 269, 1994
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1DBF
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1CMS
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1B4P
 | | CRYSTAL STRUCTURES OF CLASS MU CHIMERIC GST ISOENZYMES M1-2 AND M2-1 | | Descriptor: | L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine, PROTEIN (GLUTATHIONE S-TRANSFERASE), SULFATE ION | | Authors: | Xiao, G, Chen, J, Armstrong, R.N, Gilliland, G.L. | | Deposit date: | 1998-12-26 | | Release date: | 2003-07-08 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal Structures of Class MU Chimeric GST Isoenzymes M1-2 and M2-1
To be Published
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7RSA
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4QHU
 | | Crystal Structure of IL-17A/Fab6785 complex | | Descriptor: | CHLORIDE ION, Fab6785 heavy chain, Fab6785 light chain, ... | | Authors: | Luo, J, Gilliland, G.L, Malia, T, Obmolova, G, Teplyakov, A. | | Deposit date: | 2014-05-29 | | Release date: | 2015-08-05 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | IL-17A Asymmetry in a Complex with a Neutralizing Antibody Fab6785 Reveals a Potential Mechanism of Receptor Differentiation
To be Published
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1BE4
 | | NUCLEOSIDE DIPHOSPHATE KINASE ISOFORM B FROM BOVINE RETINA | | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, NUCLEOSIDE DIPHOSPHATE TRANSFERASE | | Authors: | Ladner, J.E, Abdulaev, N.G, Kakuev, D.L, Karaschuk, G.N, Tordova, M, Eisenstein, E, Fujiwara, J.H, Ridge, K.D, Gilliland, G.L. | | Deposit date: | 1998-05-19 | | Release date: | 1999-01-13 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Nucleoside diphosphate kinase from bovine retina: purification, subcellular localization, molecular cloning, and three-dimensional structure.
Biochemistry, 37, 1998
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1BHN
 | | NUCLEOSIDE DIPHOSPHATE KINASE ISOFORM A FROM BOVINE RETINA | | Descriptor: | GUANOSINE-3',5'-MONOPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, NUCLEOSIDE DIPHOSPHATE TRANSFERASE | | Authors: | Ladner, J.E, Abdulaev, N.G, Kakuev, D.L, Karaschuk, G.N, Tordova, M, Eisenstein, E, Fujiwara, J.H, Ridge, K.D, Gilliland, G.L. | | Deposit date: | 1998-06-10 | | Release date: | 1999-02-16 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The three-dimensional structures of two isoforms of nucleoside diphosphate kinase from bovine retina.
Acta Crystallogr.,Sect.D, 55, 1999
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6GSW
 | | FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | | Descriptor: | L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION | | Authors: | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | | Deposit date: | 1996-01-26 | | Release date: | 1996-11-08 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
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6GSV
 | | FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | | Descriptor: | L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION | | Authors: | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | | Deposit date: | 1996-01-26 | | Release date: | 1996-11-08 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
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6GSU
 | | FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | | Descriptor: | L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION | | Authors: | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | | Deposit date: | 1996-01-26 | | Release date: | 1996-11-08 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
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6GSX
 | | FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | | Descriptor: | L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION | | Authors: | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | | Deposit date: | 1996-01-26 | | Release date: | 1996-11-08 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
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5KNG
 | | CRYSTAL STRUCTURE OF ANTI-IL-13 DARPIN 6G9 | | Descriptor: | DARPIN 6G9, GLYCEROL, PHOSPHATE ION | | Authors: | Teplyakov, A, Malia, T, Obmolova, G, Gilliland, G. | | Deposit date: | 2016-06-28 | | Release date: | 2016-12-14 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Conformational flexibility of an anti-IL-13 DARPin.
Protein Eng. Des. Sel., 30, 2017
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6GSY
 | | FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | | Descriptor: | GLUTATHIONE, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3 | | Authors: | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | | Deposit date: | 1996-01-26 | | Release date: | 1996-11-08 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
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6GST
 | | FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE | | Descriptor: | GLUTATHIONE, MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3 | | Authors: | Xiao, G, Ji, X, Armstrong, R.N, Gilliland, G.L. | | Deposit date: | 1996-01-26 | | Release date: | 1996-11-08 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
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5KNH
 | | CRYSTAL STRUCTURE OF DARPIN 6G9 IN COMPLEX WITH CYNO IL-13 | | Descriptor: | ACETATE ION, DARPIN 6G9, IL13 | | Authors: | Teplyakov, A, Malia, T, Obmolova, G, Gilliland, G. | | Deposit date: | 2016-06-28 | | Release date: | 2016-12-14 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Conformational flexibility of an anti-IL-13 DARPin.
Protein Eng. Des. Sel., 30, 2017
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5L2H
 | | Crystal Structure of W26A mutant of anti-EGFR Centyrin P54AR4-83v2 | | Descriptor: | Centyrin, GLYCEROL | | Authors: | Cardoso, R.M.F, Goldberg, S.D, O Neil, K.T, Gilliland, G.L. | | Deposit date: | 2016-08-01 | | Release date: | 2016-11-02 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.8013 Å) | | Cite: | Engineering a targeted delivery platform using Centyrins.
Protein Eng. Des. Sel., 29, 2016
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1AJ9
 | | R-STATE HUMAN CARBONMONOXYHEMOGLOBIN ALPHA-A53S | | Descriptor: | CARBON MONOXIDE, HEMOGLOBIN (ALPHA CHAIN), HEMOGLOBIN (BETA CHAIN), ... | | Authors: | Vasquez, G.B, Ji, X, Fronticelli, C, Gilliland, G.L. | | Deposit date: | 1997-05-16 | | Release date: | 1998-05-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Human carboxyhemoglobin at 2.2 A resolution: structure and solvent comparisons of R-state, R2-state and T-state hemoglobins.
Acta Crystallogr.,Sect.D, 54, 1998
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2A45
 | | Crystal structure of the complex between thrombin and the central "E" region of fibrin | | Descriptor: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Fibrinogen alpha chain, Fibrinogen beta chain, ... | | Authors: | Pechik, I, Madrazo, J, Gilliland, G.L, Medved, L. | | Deposit date: | 2005-06-27 | | Release date: | 2006-05-02 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.65 Å) | | Cite: | Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly.
Biochemistry, 45, 2006
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3FYG
 | | CRYSTAL STRUCTURE OF TETRADECA-(3-FLUOROTYROSYL)-GLUTATHIONE S-TRANSFERASE | | Descriptor: | (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE, MU CLASS TETRADECA-(3-FLUOROTYROSYL)-GLUTATHIONE S-TRANSFERASE OF ISOENZYME | | Authors: | Xiao, G, Parsons, J.F, Armstrong, R.N, Gilliland, G.L. | | Deposit date: | 1997-08-07 | | Release date: | 1999-06-01 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Conformational changes in the crystal structure of rat glutathione transferase M1-1 with global substitution of 3-fluorotyrosine for tyrosine.
J.Mol.Biol., 281, 1998
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5FWG
 | | TETRA-(5-FLUOROTRYPTOPHANYL)-GLUTATHIONE TRANSFERASE | | Descriptor: | (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE, TETRA-(5-FLUOROTRYPTOPHANYL)-GLUTATHIONE TRANSFERASE MU CLASS | | Authors: | Parsons, J.F, Xiao, G, Armstrong, R.N, Gilliland, G.L. | | Deposit date: | 1997-11-08 | | Release date: | 1999-01-27 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Enzymes harboring unnatural amino acids: mechanistic and structural analysis of the enhanced catalytic activity of a glutathione transferase containing 5-fluorotryptophan.
Biochemistry, 37, 1998
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4GST
 | | REACTION COORDINATE MOTION IN AN SNAR REACTION CATALYZED BY GLUTATHIONE TRANSFERASE | | Descriptor: | 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE, GLUTATHIONE S-TRANSFERASE, SULFATE ION | | Authors: | Ji, X, Armstrong, R.N, Gilliland, G.L. | | Deposit date: | 1993-07-20 | | Release date: | 1993-10-31 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Snapshots along the reaction coordinate of an SNAr reaction catalyzed by glutathione transferase.
Biochemistry, 32, 1993
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4YDY
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