7W6O
 
 | | Crystal structure of a PSH1 in complex with J1K | | Descriptor: | 4-(2-hydroxyethylcarbamoyl)benzoic acid, PSH1 | | Authors: | Gao, J, Lara, P, Li, Z.S, Han, X, Wei, R, Liu, W.D. | | Deposit date: | 2021-12-02 | | Release date: | 2022-09-14 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase.
Acs Catalysis, 12, 2022
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7W6Q
 | | Crystal structure of a PSH1 in complex with ligand J1K | | Descriptor: | 4-(2-hydroxyethylcarbamoyl)benzoic acid, PSH1 | | Authors: | Gao, J, Lara, P, Li, Z.S, Han, X, Wei, R, Liu, W.D. | | Deposit date: | 2021-12-02 | | Release date: | 2022-09-14 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase.
Acs Catalysis, 12, 2022
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5YGK
 | | Crystal structure of a synthase from Streptomyces sp. CL190 with dmaspp | | Descriptor: | Cyclolavandulyl diphosphate synthase, DIMETHYLALLYL S-THIOLODIPHOSPHATE, MAGNESIUM ION | | Authors: | Gao, J, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2017-09-23 | | Release date: | 2018-07-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.047 Å) | | Cite: | Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes.
Acs Catalysis, 8, 2018
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4MOD
 | | Structure of the MERS-CoV fusion core | | Descriptor: | HR1 of S protein, LINKER, HR2 of S protein | | Authors: | Gao, J, Lu, G, Qi, J, Li, Y, Wu, Y, Deng, Y, Geng, H, Xiao, H, Tan, W, Yan, J, Gao, G.F. | | Deposit date: | 2013-09-12 | | Release date: | 2013-10-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Structure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus.
J.Virol., 87, 2013
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5YGJ
 | | Crystal structure of a synthase from Streptomyces sp. CL190 | | Descriptor: | Cyclolavandulyl diphosphate synthase | | Authors: | Gao, J, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2017-09-23 | | Release date: | 2018-07-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.648 Å) | | Cite: | Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes.
Acs Catalysis, 8, 2018
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3WYJ
 | | Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-789 | | Descriptor: | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), [1-oxidanyl-2-[3-[3-[[3-[[3-[3-(2-oxidanyl-2,2-diphosphono-ethyl)phenyl]phenyl]sulfamoyl]phenyl]sulfonylamino]phenyl]phenyl]-1-phosphono-ethyl]phosphonic acid | | Authors: | Gao, J, Ko, T.P, Huang, C.H, Oldfield, E, Guo, R.T. | | Deposit date: | 2014-08-29 | | Release date: | 2015-02-04 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Antibacterial drug leads: DNA and enzyme multitargeting.
J.Med.Chem., 58, 2015
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3WYI
 | | Structure of S. aureus undecaprenyl diphosphate synthase | | Descriptor: | Isoprenyl transferase, MAGNESIUM ION | | Authors: | Gao, J, Ko, T.P, Huang, C.H, Oldfield, E, Guo, R.T. | | Deposit date: | 2014-08-29 | | Release date: | 2015-02-04 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Antibacterial drug leads: DNA and enzyme multitargeting.
J.Med.Chem., 58, 2015
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8DL5
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9O9U
 | | The Erlin1/2 complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Erlin-1, Erlin-2 | | Authors: | Gao, J, Shao, S. | | Deposit date: | 2025-04-18 | | Release date: | 2025-10-22 | | Last modified: | 2025-12-24 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structures of human organellar SPFH protein complexes.
Nat Commun, 16, 2025
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9OA0
 | | The human PHB1/2 complex (open) | | Descriptor: | Prohibitin 1, Prohibitin-2 | | Authors: | Gao, J, Shao, S, Sherpa, D, Kupko, N. | | Deposit date: | 2025-04-18 | | Release date: | 2025-10-22 | | Last modified: | 2025-12-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structures of human organellar SPFH protein complexes.
Nat Commun, 16, 2025
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9O9Z
 | | The human PHB1/2 complex (closed) | | Descriptor: | Prohibitin 1, Prohibitin-2 | | Authors: | Gao, J, Shao, S, Sherpa, D, Kupko, N. | | Deposit date: | 2025-04-18 | | Release date: | 2025-10-22 | | Last modified: | 2025-12-24 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Structures of human organellar SPFH protein complexes.
Nat Commun, 16, 2025
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1BO9
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9BV2
 | | M2B Midnolin-Proteasome (translocating) | | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, ... | | Authors: | Gao, J, Yip, M.C.J, Shao, S. | | Deposit date: | 2024-05-19 | | Release date: | 2025-06-11 | | Last modified: | 2025-12-24 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Mol.Cell, 85, 2025
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9BW4
 | | TXNL1-bound proteasome | | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, ... | | Authors: | Gao, J, Yip, M.C.J, Shao, S. | | Deposit date: | 2024-05-20 | | Release date: | 2025-06-11 | | Last modified: | 2025-12-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of the TXNL1-bound proteasome.
Nat.Struct.Mol.Biol., 32, 2025
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9BV1
 | | M2A Midnolin-Proteasome (translocating) | | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, ... | | Authors: | Gao, J, Yip, M.C.J, Shao, S. | | Deposit date: | 2024-05-19 | | Release date: | 2025-06-11 | | Last modified: | 2025-12-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Mol.Cell, 85, 2025
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9BV3
 | | M1B Midnolin-Proteasome | | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, ... | | Authors: | Gao, J, Yip, M.C.J, Shao, S. | | Deposit date: | 2024-05-19 | | Release date: | 2025-06-11 | | Last modified: | 2025-12-24 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Mol.Cell, 85, 2025
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9BUI
 | | M1A Midnolin-Proteasome (with Ubl) | | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, ... | | Authors: | Gao, J, Yip, M.C.J, Shao, S. | | Deposit date: | 2024-05-17 | | Release date: | 2025-06-11 | | Last modified: | 2025-12-24 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Mol.Cell, 85, 2025
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9AZB
 | | Crystal structure of LolTv5 | | Descriptor: | Aminotransferase, class V/Cysteine desulfurase, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Gao, J, Hai, Y. | | Deposit date: | 2024-03-11 | | Release date: | 2024-07-17 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Enzymatic Synthesis of Unprotected alpha , beta-Diamino Acids via Direct Asymmetric Mannich Reactions.
J.Am.Chem.Soc., 146, 2024
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9AZA
 | | Crystal structure of LolTv4 | | Descriptor: | Aminotransferase, class V/Cysteine desulfurase, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Gao, J, Hai, Y. | | Deposit date: | 2024-03-10 | | Release date: | 2024-07-17 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (2.84 Å) | | Cite: | Enzymatic Synthesis of Unprotected alpha , beta-Diamino Acids via Direct Asymmetric Mannich Reactions.
J.Am.Chem.Soc., 146, 2024
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5GM9
 | | Crystal structure of a glycoside hydrolase in complex with cellobiose | | Descriptor: | Glycoside hydrolase family 45 protein, beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | | Authors: | Gao, J, Liu, W.D, Zheng, Y.Y, Chen, C.C, Guo, R.T. | | Deposit date: | 2016-07-13 | | Release date: | 2017-04-19 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.36 Å) | | Cite: | Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-beta-endoglucanase from Thielavia terrestris
Enzyme Microb. Technol., 99, 2017
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5GLX
 | | Crystal structure of a glycoside hydrolase from Thielavia terrestris NRRL 8126 | | Descriptor: | Glycoside hydrolase family 45 protein | | Authors: | Gao, J, Liu, W.D, Zheng, Y.Y, Chen, C.C, Guo, R.T. | | Deposit date: | 2016-07-12 | | Release date: | 2017-04-19 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-beta-endoglucanase from Thielavia terrestris
Enzyme Microb. Technol., 99, 2017
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5GLY
 | | Crystal structure of a glycoside hydrolase in complex with cellotetrose from Thielavia terrestris NRRL 8126 | | Descriptor: | Glycoside hydrolase family 45 protein, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | | Authors: | Gao, J, Liu, W.D, Zheng, Y.Y, Chen, C.C, Guo, R.T. | | Deposit date: | 2016-07-12 | | Release date: | 2017-04-19 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-beta-endoglucanase from Thielavia terrestris
Enzyme Microb. Technol., 99, 2017
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5ZXA
 | | Crystal structure of fibronectin-binding protein Apa mutant from Mycobacterium tuberculosis | | Descriptor: | Alanine and proline-rich secreted protein Apa, GLYCEROL, MERCURY (II) ION | | Authors: | Gao, J, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2018-05-18 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium tuberculosis.
Biochim Biophys Acta Gen Subj, 1863, 2019
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5ZX9
 | | Crystal structure of apo form fibronectin-binding protein Apa from Mycobacterium tuberculosis | | Descriptor: | Alanine and proline-rich secreted protein Apa, GLYCEROL | | Authors: | Gao, J, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2018-05-18 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium tuberculosis.
Biochim Biophys Acta Gen Subj, 1863, 2019
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4KS8
 | | PAK6 kinase domain in complex with sunitinib | | Descriptor: | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, Serine/threonine-protein kinase PAK 6 | | Authors: | Gao, J, Boggon, T.J. | | Deposit date: | 2013-05-17 | | Release date: | 2013-09-11 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6.
Plos One, 8, 2013
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