5ZXA

Crystal structure of fibronectin-binding protein Apa mutant from Mycobacterium tuberculosis

Summary for 5ZXA

Entry DOI	10.2210/pdb5zxa/pdb
Descriptor	Alanine and proline-rich secreted protein Apa, MERCURY (II) ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	substrate binding, cyclolavandulyl diphosphate synthase, inhibitor, protein binding
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	1
Total formula weight	33066.27
Authors	Gao, J.,Liu, W.D.,Chen, C.C.,Guo, R.T. (deposition date: 2018-05-18, release date: 2019-05-29, Last modification date: 2024-03-27)
Primary citation	Kuo, C.J.,Gao, J.,Huang, J.W.,Ko, T.P.,Zhai, C.,Ma, L.,Liu, W.,Dai, L.,Chang, Y.F.,Chen, T.H.,Hu, Y.,Yu, X.,Guo, R.T.,Chen, C.C. Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium tuberculosis. Biochim Biophys Acta Gen Subj, 1863:1351-1359, 2019 Cited by PubMed Abstract: Alanine and proline-rich protein (Apa) is a secreted antigen of Mycobacterium spp. which involves in stimulating immune responses and adhering to host cells by binding to fibronectin (Fn). Here, we report the crystal structure of Apa from Mycobacterium tuberculosis (Mtb) and its Fn-binding characteristics. PubMed: 31175911 DOI: 10.1016/j.bbagen.2019.06.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation