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PDB: 54 件
1ZJK
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Crystal structure of the zymogen catalytic region of human MASP-2
分子名称: Mannan-binding lectin serine protease 2
著者Gal, P, Harmat, V, Kocsis, A, Bian, T, Barna, L, Ambrus, G, Vegh, B, Balczer, J, Sim, R.B, Naray-Szabo, G, Zavodszky, P.
登録日2005-04-29
公開日2005-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献A True Autoactivating Enzyme: Structural insight into mannose-binding lectin-associated serine protease-2 activations
J.Biol.Chem., 280, 2005
4UEE
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Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OH
分子名称: (2S)-2-{[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, CARBOXYPEPTIDASE A1, ZINC ION
著者Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D.
登録日2014-12-17
公開日2016-01-20
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
To be Published
4UEZ
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Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Phe-Y(PO2CH2)-Phe-OH
分子名称: (2S)-3-[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]-2-phenylethyl}(hydroxy)phosphoryl]-2-benzylpropanoic acid, HUMAN CARBOXYPEPTIDASE A1, ZINC ION
著者Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D.
登録日2014-12-22
公開日2016-01-20
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
To be Published
5OM9
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Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor
分子名称: (2~{R})-4-methyl-2-[(1~{S})-1-sulfanylethyl]pentanoic acid, Carboxypeptidase A1, ZINC ION
著者Gallego, P, Granados, C, Fernandez, D, Pallares, I, Covaleda, G, Aviles, F.X, Vendrell, J, Reverter, D.
登録日2017-07-28
公開日2017-08-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.
ACS Med Chem Lett, 8, 2017
7QCU
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BU of 7qcu by Molmil
Structure of the MUCIN-2 Cterminal domains partially deglycosylated.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mucin-2, ...
著者Gallego, P, Hansson, G.C.
登録日2021-11-25
公開日2023-03-08
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins.
Nat Commun, 14, 2023
7QCN
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Structure of the MUCIN-2 Cterminal domains: vWCN to TIL domains with a C2 symmetry
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mucin-2, ...
著者Gallego, P, Hansson, G.C.
登録日2021-11-24
公開日2023-03-08
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins.
Nat Commun, 14, 2023
7QCL
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Structure of the MUCIN-2 Cterminal domains
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mucin-2, ...
著者Gallego, P, Hansson, G.C.
登録日2021-11-24
公開日2023-03-08
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins.
Nat Commun, 14, 2023
6I6Z
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Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Tyr-Ala-Y(PO2CH2)-homoPhe-OH
分子名称: (2S)-2-{[(S)-{(1R)-1-[(N-acetyl-L-tyrosyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, Carboxypeptidase A1, ZINC ION
著者Gallego, P, Reverter, D.
登録日2018-11-15
公開日2018-12-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes.
J. Med. Chem., 62, 2019
3NS7
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Succinic Acid Amides as P2-P3 Replacements for Inhibitors of Interleukin-1beta Converting Enzyme (ICE or Caspase 1)
分子名称: (3S)-4-hydroxy-3-{[(2S)-4-{[2-(2-methyl-1H-benzimidazol-1-yl)ethyl]amino}-2-(1-methylethyl)-4-oxobutanoyl]amino}butanoic acid, Caspase-1
著者Galatsis, P.
登録日2010-07-01
公開日2011-08-17
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).
Bioorg.Med.Chem.Lett., 20, 2010
5LQG
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BU of 5lqg by Molmil
A two-quartet G-quadruplex formed by human telomere in KCl solution at neutral pH
分子名称: DNA (5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*G)-3')
著者Galer, P, Wang, B, Sket, P, Plavec, J.
登録日2016-08-17
公開日2018-06-13
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Reversible pH Switch of Two-Quartet G-Quadruplexes Formed by Human Telomere.
Angew.Chem.Int.Ed.Engl., 55, 2016
5LQH
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BU of 5lqh by Molmil
A two-quartet G-quadruplex formed by human telomere in KCl solution at pH 5.0
分子名称: DNA (5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*G)-3')
著者Galer, P, Wang, B, Sket, P, Plavec, J.
登録日2016-08-17
公開日2018-01-17
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Reversible pH Switch of Two-Quartet G-Quadruplexes Formed by Human Telomere.
Angew.Chem.Int.Ed.Engl., 55, 2016
5FW6
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BU of 5fw6 by Molmil
Structure of human transthyretin mutant A108V
分子名称: TRANSTHYRETIN
著者Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D.
登録日2016-02-12
公開日2017-03-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep, 7, 2017
5AQ0
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BU of 5aq0 by Molmil
The structure of the Transthyretin-like domain of the first catalytic domain of the HUMAN Carboxypeptidase D
分子名称: CARBOXYPEPTIDASE D, GLYCEROL
著者Gallego, P, Garcia-Pardo, J, Lorenzo, J, Aviles, F.X, Ventura, S, Reverter, D.
登録日2015-09-18
公開日2016-09-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献The Structure of the Ttldomain of the Human Carboxypeptidase D
To be Published
5AEK
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Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W
分子名称: SENTRIN-SPECIFIC PROTEASE 2, SMALL UBIQUITIN-RELATED MODIFIER 1
著者Gallego, P, Grana-Montes, R, Espargaro, A, Castillo, V, Torrent, J, Lange, R, Papaleo, E, Lindorff-Larsend, K, Ventura, S, Reverter, D.
登録日2014-12-23
公開日2016-01-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Stepping Back and Forward on Sumo Folding Evolution
To be Published
5FW7
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BU of 5fw7 by Molmil
Structure of human transthyretin mutant A109V
分子名称: TRANSTHYRETIN
著者Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D.
登録日2016-02-12
公開日2017-03-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structure of New Non-Amyloidogenic Mutant of Ttr A108V
To be Published
5FW9
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BU of 5fw9 by Molmil
Human Spectrin SH3 domain D48G, E7Y, K60Y
分子名称: SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1
著者Gallego, P, Navarro, S, Ventura, S, Reverter, D.
登録日2016-02-12
公開日2016-12-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Human Spectrin SH3 Domain D48G, E7Y, K60Y
To be Published
5FWC
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Human Spectrin SH3 domain D48G, E7A, K60A
分子名称: 1,2-ETHANEDIOL, AMMONIUM ION, SPECTRIN ALPHA CHAIN, ...
著者Gallego, P, Navarro, S, Ventura, S, Reverter, D.
登録日2016-02-12
公開日2016-12-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Human Spectrin SH3 Domain D48G, E7A, K60A
To be Published
5FWB
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BU of 5fwb by Molmil
Human Spectrin SH3 domain D48G, E7F, K60F
分子名称: SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1
著者Gallego, P, Navarro, S, Ventura, S, Reverter, D.
登録日2016-02-12
公開日2016-12-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Human Spectrin SH3 Domain D48G, E7F, K60F
To be Published
5FW8
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BU of 5fw8 by Molmil
Structure of human transthyretin mutant E89K
分子名称: TRANSTHYRETIN
著者Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D.
登録日2016-02-12
公開日2016-12-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of New Non-Amyloidogenic Mutant of Ttr A108V
To be Published
3ZKF
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Structure of LC8 in complex with Nek9 phosphopeptide
分子名称: DYNEIN LIGHT CHAIN 1, CYTOPLASMIC, NEK9 PROTEIN
著者Gallego, P, Velazquez-Campoy, A, Regue, L, Roig, J, Reverter, D.
登録日2013-01-22
公開日2013-03-20
最終更新日2013-05-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Analysis of the Regulation of the Dynll/Lc8 Binding to Nek9 by Phosphorylation
J.Biol.Chem., 288, 2013
3ZKE
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Structure of LC8 in complex with Nek9 peptide
分子名称: DYNEIN LIGHT CHAIN 1, CYTOPLASMIC, NEK9 PROTEIN
著者Gallego, P, Velazquez-Campoy, A, Regue, L, Roig, J, Reverter, D.
登録日2013-01-22
公開日2013-03-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Analysis of the Regulation of the Dynll/Lc8 Binding to Nek9 by Phosphorylation
J.Biol.Chem., 288, 2013
4AXS
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BU of 4axs by Molmil
Structure of Carbamate Kinase from Mycoplasma penetrans
分子名称: CARBAMATE KINASE, SULFATE ION
著者Gallego, P, Planell, R, Benach, J, Querol, E, PerezPons, J.A, Reverter, D.
登録日2012-06-14
公開日2012-10-03
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Characterization of the Enzymes Composing the Arginine Deiminase Pathway in Mycoplasma Penetrans.
Plos One, 7, 2012
4AMU
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Structure of ornithine carbamoyltransferase from Mycoplasma penetrans with a P321 space group
分子名称: ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC
著者Gallego, P, Benach, J, Planell, R, Querol, E, Perez-Pons, J.A, Reverter, D.
登録日2012-03-13
公開日2012-03-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Characterization of the Enzymes Composing the Arginine Deiminase Pathway in Mycoplasma Penetrans.
Plos One, 7, 2012
4D7B
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BU of 4d7b by Molmil
Structure of human transthyretin in complex with Tolcapone
分子名称: TRANSTHYRETIN, Tolcapone
著者Gallego, P, Sant'anna, R.O, Ventura, S, Reverter, D.
登録日2014-11-21
公開日2016-01-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity
Nat.Commun., 7, 2016
4ANF
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BU of 4anf by Molmil
Structure of the ornithine carbamoyltransferase from Mycoplasma penetrans with a P23 Space group
分子名称: ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC
著者Gallego, P, Benach, J, Planell, R, Querol, E, Perez-Pons, J.A, Reverter, D.
登録日2012-03-16
公開日2012-03-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Characterization of the Enzymes Composing the Arginine Deiminase Pathway in Mycoplasma Penetrans.
Plos One, 7, 2012

 

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