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PDB: 49 件
5K2X
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BU of 5k2x by Molmil
Crystal structure of M. tuberculosis UspC (tetragonal crystal form)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, IODIDE ION, ...
著者Futterer, K, Fullam, E, Besra, G.S.
登録日2016-05-19
公開日2016-06-01
最終更新日2023-03-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars.
Open Biology, 6, 2016
5K2Y
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BU of 5k2y by Molmil
Crystal structure of M. tuberculosis UspC (monoclinic crystal form)
分子名称: Probable periplasmic sugar-binding lipoprotein UspC
著者Futterer, K, Fullam, E, Besra, G.S.
登録日2016-05-19
公開日2016-06-01
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars.
Open Biology, 6, 2016
5JY7
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BU of 5jy7 by Molmil
Complex of Mycobacterium smegmatis trehalose synthase with maltokinase
分子名称: CALCIUM ION, Maltokinase, Trehalose synthase/amylase TreS
著者Futterer, K, Kermani, A.A, Besra, G.S.
登録日2016-05-13
公開日2017-05-24
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Crystal structure of the TreS-Pep2 complex, initiating alpha-glucan synthesis in the GlgE pathway of mycobacteria.
J.Biol.Chem., 2019
5OEP
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BU of 5oep by Molmil
Mycobacterium tuberculosis DprE1 in complex with inhibitor TCA481
分子名称: Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, IMIDAZOLE, ...
著者Futterer, K, Batt, S.M, Besra, G.S.
登録日2017-07-09
公開日2018-05-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017
5OEL
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BU of 5oel by Molmil
Mycobacterium tuberculosis DprE1 mutant Y314C in complex with TCA1
分子名称: Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]thiophen-3-yl}carbonyl)carbamate
著者Futterer, K, Batt, S.M, Besra, G.S.
登録日2017-07-08
公開日2018-05-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017
5OEQ
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BU of 5oeq by Molmil
Mycobacterium tuberculosis DprE1 in complex with inhibitor TCA020
分子名称: Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, IMIDAZOLE, ...
著者Futterer, K, Batt, S.M, Besra, G.S.
登録日2017-07-09
公開日2018-05-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017
2FEZ
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BU of 2fez by Molmil
Mycobacterium tuberculosis EmbR
分子名称: Probable regulatory protein embR
著者Futterer, K, Alderwick, L.J, Besra, G.S.
登録日2005-12-17
公開日2006-01-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FF4
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Mycobacterium tuberculosis EmbR in complex with low affinity phosphopeptide
分子名称: DNA repair protein RAD9, Probable regulatory protein embR
著者Futterer, K, Alderwick, L.J, Besra, G.S.
登録日2005-12-19
公開日2006-01-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.Usa, 103, 2006
5OCW
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BU of 5ocw by Molmil
Structure of Mycobacterium tuberculosis tryptophan synthase in space group F222
分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Tryptophan synthase alpha chain, Tryptophan synthase beta chain
著者Futterer, K, Abrahams, K, Cox, J.A.G, Besra, G.S.
登録日2017-07-03
公開日2017-07-12
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.
Sci Rep, 7, 2017
6HF0
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BU of 6hf0 by Molmil
M. tuberculosis DprE1 covalently bound to a nitrobenzoxacinone.
分子名称: 2-[(2~{S},6~{R})-2,6-dimethylpiperidin-1-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzoxazin-4-one, Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE
著者Futterer, K, Batt, S.M, Besra, G.S.
登録日2018-08-21
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.384 Å)
主引用文献Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.
Sci Rep, 8, 2018
6HF3
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M tuberculosis DprE1 in complex with a covalently bound nitrobenzothiazinone
分子名称: 2-(4-(cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one, bound form, Decaprenylphosphoryl-beta-D-ribose oxidase, ...
著者Futterer, K, Batt, S.M, Besra, G.S.
登録日2018-08-21
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.
Sci Rep, 8, 2018
6HEZ
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BU of 6hez by Molmil
M tuberculosis DprE1 in complex with BTZ043
分子名称: 8-(hydroxyamino)-2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one, Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Futterer, K, Batt, S.M, Besra, G.S.
登録日2018-08-21
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.
Sci Rep, 8, 2018
3BYL
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BU of 3byl by Molmil
Crystal structure of B. subtilis levansucrase mutant E342A
分子名称: Levansucrase
著者Futterer, K, Meng, G.
登録日2008-01-16
公開日2008-02-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Donor substrate recognition in the raffinose-bound E342A mutant of fructosyltransferase Bacillus subtilis levansucrase
To be Published
3BYK
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BU of 3byk by Molmil
Crystal structure of B. subtilis levansucrase mutant D247A
分子名称: CALCIUM ION, Levansucrase
著者Futterer, K, Meng, G.
登録日2008-01-16
公開日2008-02-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Donor substrate recognition in the raffinose-bound E342A mutant of fructosyltransferase Bacillus subtilis levansucrase
To be Published
3BYN
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BU of 3byn by Molmil
Crystal structure of B. subtilis levansucrase mutant E342A bound to raffinose
分子名称: CALCIUM ION, Levansucrase, alpha-D-galactopyranose-(1-6)-alpha-D-glucopyranose-(1-2)-beta-D-fructofuranose
著者Futterer, K, Meng, G.
登録日2008-01-16
公開日2008-02-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Donor substrate recognition in the raffinose-bound E342A mutant of fructosyltransferase Bacillus subtilis levansucrase
To be Published
3BYJ
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BU of 3byj by Molmil
Crystal structure of B. subtilis levansucrase mutant D86A
分子名称: CALCIUM ION, Levansucrase
著者Futterer, K, Meng, G.
登録日2008-01-16
公開日2008-02-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Donor substrate recognition in the raffinose-bound E342A mutant of fructosyltransferase Bacillus subtilis levansucrase
To be Published
3FVE
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BU of 3fve by Molmil
Crystal structure of diaminopimelate epimerase Mycobacterium tuberculosis DapF
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Diaminopimelate epimerase, GLYCEROL
著者Usha, V, Dover, L.G, Roper, D.I, Futterer, K, Besra, G.S.
登録日2009-01-15
公開日2009-01-27
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis
Acta Crystallogr.,Sect.D, 65, 2009
4RMF
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BU of 4rmf by Molmil
Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target
分子名称: 2,2-bis(hydroxymethyl)propane-1,3-diol, Aspartate--tRNA(Asp/Asn) ligase, FORMIC ACID
著者Cox, J.A.G, Gurcha, S.S, Veeraraghavan, U, Besra, G.S, Futterer, K.
登録日2014-10-21
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target.
Plos One, 9, 2014
1Y2O
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BU of 1y2o by Molmil
Structure of N-terminal domain IRSp53/BAIAP2
分子名称: BAI1-associated protein 2 isoform 1
著者Millard, T.H, Bompard, G, Heung, M.-Y, Dafforn, T.R, Scott, D.J, Machesky, L.M, Futterer, K.
登録日2004-11-23
公開日2005-02-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53
Embo J., 24, 2005
4KW5
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BU of 4kw5 by Molmil
M. tuberculosis DprE1 in complex with inhibitor TCA1
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, IMIDAZOLE, ...
著者Batt, S.M, Besra, G.S, Futterer, K.
登録日2013-05-23
公開日2013-07-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.612 Å)
主引用文献Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.
Proc.Natl.Acad.Sci.USA, 110, 2013
1B7X
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BU of 1b7x by Molmil
STRUCTURE OF HUMAN ALPHA-THROMBIN Y225I MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE
分子名称: PROTEIN (INHIBITOR), PROTEIN (THROMBIN HEAVY CHAIN), PROTEIN (THROMBIN LIGHT CHAIN)
著者Caccia, S, Futterer, K, Di Cera, E, Waksman, G.
登録日1999-01-25
公開日1999-03-02
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Unexpected crucial role of residue 225 in serine proteases.
Proc.Natl.Acad.Sci.USA, 96, 1999
3OKA
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BU of 3oka by Molmil
Crystal structure of Corynebacterium glutamicum PimB' in complex with GDP-Man (triclinic crystal form)
分子名称: GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ...
著者Batt, S.M, Jabeen, T, Besra, G.S, Futterer, K.
登録日2010-08-24
公開日2010-09-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.
J.Biol.Chem., 285, 2010
3OKC
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BU of 3okc by Molmil
Crystal structure of Corynebacterium glutamicum PimB' bound to GDP (orthorhombic crystal form)
分子名称: GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase, GUANOSINE-5'-DIPHOSPHATE
著者Batt, S.M, Jabeen, T, Besra, G.S, Futterer, K.
登録日2010-08-24
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.
J.Biol.Chem., 285, 2010
3OKP
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BU of 3okp by Molmil
Crystal structure of Corynebacterium glutamicum PimB' bound to GDP-Man (orthorhombic crystal form)
分子名称: GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE
著者Batt, S.M, Jabeen, T, Besra, G.S, Futterer, K.
登録日2010-08-25
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.
J.Biol.Chem., 285, 2010
2Q74
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Mycobacterium tuberculosis SuhB
分子名称: Inositol-1-monophosphatase
著者Brown, A.K, Meng, G, Ghadbane, H, Besra, G.S, Futterer, K.
登録日2007-06-06
公開日2007-10-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+
Bmc Struct.Biol., 7, 2007

 

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