6HEZ

M tuberculosis DprE1 in complex with BTZ043

Summary for 6HEZ

• Entry DOI: 10.2210/pdb6hez/pdb
• Descriptor: Decaprenylphosphoryl-beta-D-ribose oxidase, 8-(hydroxyamino)-2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• Functional Keywords: oxidation-reduction process, isomerase, arabinan biosynthetic process, flavoprotein
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 107257.66

Authors

Futterer, K.,Batt, S.M.,Besra, G.S. (deposition date: 2018-08-21, release date: 2018-08-29, Last modification date: 2024-01-17)

• Primary citation: Richter, A.,Rudolph, I.,Mollmann, U.,Voigt, K.,Chung, C.W.,Singh, O.M.P.,Rees, M.,Mendoza-Losana, A.,Bates, R.,Ballell, L.,Batt, S.,Veerapen, N.,Futterer, K.,Besra, G.,Imming, P.,Argyrou, A.; Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.; Sci Rep, 8:13473-13473, 2018; PubMed: 30194385; DOI: 10.1038/s41598-018-31316-6

Experimental method

X-RAY DIFFRACTION (2.3 Å)