6HEZ

M tuberculosis DprE1 in complex with BTZ043

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Decaprenylphosphoryl-beta-D-ribose oxidase	polymer	481	52391.3	2	UniProt (P9WJF1) Pfam (PF01565) Pfam (PF04030)	Mycobacterium tuberculosis	Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase,Decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase subunit DprE1,Decaprenyl-phosphoribose 2'-epimerase subunit 1,Decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase,Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit,FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase
2	C, F (A, B)	8-(hydroxyamino)-2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one	non-polymer		417.4	2	Chemie (0SK)
3	D, G (A, B)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
4	E (A)	IMIDAZOLE	non-polymer		69.1	1	Chemie (IMD)
5	H, I (A, B)	water	water		18.0	76	Chemie (HOH)

Sequence modifications

A, B: 1 - 461 (UniProt: P9WJF1)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	104782.7
Non-Polymers*	Number of molecules	5
	Total formula weight	2475.0
All*	Total formula weight	107257.7

*Water molecules are not included.