6HF3

M tuberculosis DprE1 in complex with a covalently bound nitrobenzothiazinone

Summary for 6HF3

Entry DOI	10.2210/pdb6hf3/pdb
Related	6HEZ 6HF0
Descriptor	Decaprenylphosphoryl-beta-D-ribose oxidase, 2-(4-(cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one, bound form, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	oxidation-reduction process, isomerase, arabinan biosynthetic process, flavoprotein
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	107238.76
Authors	Futterer, K.,Batt, S.M.,Besra, G.S. (deposition date: 2018-08-21, release date: 2018-08-29, Last modification date: 2024-01-17)
Primary citation	Richter, A.,Rudolph, I.,Mollmann, U.,Voigt, K.,Chung, C.W.,Singh, O.M.P.,Rees, M.,Mendoza-Losana, A.,Bates, R.,Ballell, L.,Batt, S.,Veerapen, N.,Futterer, K.,Besra, G.,Imming, P.,Argyrou, A. Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1. Sci Rep, 8:13473-13473, 2018 Cited by PubMed: 30194385 DOI: 10.1038/s41598-018-31316-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation