7RJZ
 
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3UVU
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6P6E
 | | Structure of Mouse Importin alpha - PAC3 NLS peptide complex | | Descriptor: | Importin subunit alpha-1, PAC3 NLS | | Authors: | Bernardes, N.E, Silva, T.D, Fukuda, C.A, Oliveira, H.C, Fontes, M.R.M. | | Deposit date: | 2019-06-03 | | Release date: | 2020-01-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha.
Sci Rep, 10, 2020
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6P6A
 | | Structure of Mouse Importin alpha - NIT2 NLS peptide complex | | Descriptor: | Importin subunit alpha-1, Nitrogen catabolic enzyme regulatory protein | | Authors: | Bernardes, N.E, Fukuda, C.A, Silva, T.D, Oliveira, H.C, Fontes, M.R.M. | | Deposit date: | 2019-06-03 | | Release date: | 2020-01-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.151 Å) | | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha.
Sci Rep, 10, 2020
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6PWH
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7ROX
 | | BthTX-I complexed with inhibitor MMV | | Descriptor: | 12-methoxy-Nb-methylvoachalotine, Basic phospholipase A2 homolog bothropstoxin-I | | Authors: | Borges, R.J, De Marino, I, Uson, I, Fontes, M.R.M. | | Deposit date: | 2021-08-02 | | Release date: | 2022-11-09 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural and functional studies of a snake venom phospholipase A 2 -like protein complexed to an inhibitor from Tabernaemontana catharinensis.
Biochimie, 206, 2023
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3T0R
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1IQ1
 | | CRYSTAL STRUCTURE OF THE IMPORTIN-ALPHA(44-54)-IMPORTIN-ALPHA(70-529) COMPLEX | | Descriptor: | IMPORTIN ALPHA-2 SUBUNIT | | Authors: | Catimel, B, Teh, T, Fontes, M.R.M, Jennings, I.G, Kobe, B. | | Deposit date: | 2001-05-28 | | Release date: | 2001-11-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Biophysical characterization of interactions involving importin-alpha during nuclear import.
J.Biol.Chem., 276, 2001
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4WTB
 | | BthTX-I, a svPLA2s-like toxin, complexed with zinc ions | | Descriptor: | Basic phospholipase A2 homolog bothropstoxin-1, CHLORIDE ION, SULFATE ION, ... | | Authors: | Borges, R.J, Fontes, M.R.M. | | Deposit date: | 2014-10-29 | | Release date: | 2015-11-11 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Functional and structural studies of a Phospholipase A2-like protein complexed to zinc ions: Insights on its myotoxicity and inhibition mechanism.
Biochim. Biophys. Acta, 1861, 2017
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1HOR
 | | STRUCTURE AND CATALYTIC MECHANISM OF GLUCOSAMINE 6-PHOSPHATE DEAMINASE FROM ESCHERICHIA COLI AT 2.1 ANGSTROMS RESOLUTION | | Descriptor: | 2-DEOXY-2-AMINO GLUCITOL-6-PHOSPHATE, GLUCOSAMINE 6-PHOSPHATE DEAMINASE, PHOSPHATE ION | | Authors: | Oliva, G, Fontes, M.R.M, Garratt, R.C, Altamirano, M.M, Calcagno, M.L, Horjales, E. | | Deposit date: | 1995-09-13 | | Release date: | 1996-01-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from Escherichia coli at 2.1 A resolution.
Structure, 3, 1995
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4RXH
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6MQF
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6MQD
 | | Myotoxin II from Bothrops moojeni complexed with Rosmarinic Acid | | Descriptor: | (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid, Basic phospholipase A2 homolog 2 | | Authors: | Salvador, G.H.M, Fontes, M.R.M. | | Deposit date: | 2018-10-09 | | Release date: | 2019-03-20 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A2-like proteins using functional, structural and bioinformatics approaches.
Sci Rep, 9, 2019
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3CXI
 | | Structure of BthTX-I complexed with alpha-tocopherol | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Myotoxic phospholipase A2-like, SULFATE ION, ... | | Authors: | dos Santos, J.I, Fontes, M.R.M. | | Deposit date: | 2008-04-24 | | Release date: | 2009-05-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Comparative structural studies on Lys49-phospholipases A(2) from Bothrops genus reveal their myotoxic site.
J.Struct.Biol., 167, 2009
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3CYL
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7LYE
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3L3Q
 | | Mouse importin alpha-pepTM NLS peptide complex | | Descriptor: | CITRATE ANION, Importin subunit alpha-2, pepTM | | Authors: | Takeda, A.A.S, Kobe, B, Fontes, M.R.M. | | Deposit date: | 2009-12-17 | | Release date: | 2010-04-07 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening.
J.Biol.Chem., 285, 2010
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6WBB
 | | Structure of Mouse Importin alpha - MLH1-E475A NLS peptide complex | | Descriptor: | DNA mismatch repair protein Mlh1, Importin subunit alpha-1 | | Authors: | De Barros, A.C, Da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M. | | Deposit date: | 2020-03-26 | | Release date: | 2021-07-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.663 Å) | | Cite: | Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Biochem.J., 478, 2021
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6WBA
 | | Structure of Mouse Importin alpha MLH1- R470A NLS Peptide Complex | | Descriptor: | DNA mismatch repair protein Mlh1, Importin subunit alpha-1 | | Authors: | de Barros, A.C, da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M. | | Deposit date: | 2020-03-26 | | Release date: | 2021-07-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.151 Å) | | Cite: | Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Biochem.J., 478, 2021
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6WBC
 | | Structure of Mouse Importin alpha- MLH1-R472K NLS Peptide Complex | | Descriptor: | DNA mismatch repair protein Mlh1, Importin subunit alpha-1 | | Authors: | de Barros, A.C, da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M. | | Deposit date: | 2020-03-26 | | Release date: | 2021-07-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Biochem.J., 478, 2021
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3QNL
 | | Crystal structure of PrTX-I complexed to Rosmarinic Acid | | Descriptor: | (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ISOPROPYL ALCOHOL, ... | | Authors: | dos Santos, J.I, Fontes, M.R.M. | | Deposit date: | 2011-02-08 | | Release date: | 2012-02-29 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Structural and Functional Studies of a Bothropic Myotoxin Complexed to Rosmarinic Acid: New Insights into Lys49-PLA(2) Inhibition.
Plos One, 6, 2011
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2OQD
 | | Crystal Structure of BthTX-II | | Descriptor: | Phospholipase A2 | | Authors: | Correa, L.C, Marchi-Salvador, D.P, Cintra, A.C.O, Soares, A.M, Fontes, M.R.M. | | Deposit date: | 2007-01-31 | | Release date: | 2008-02-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Crystal structure of a myotoxic Asp49-phospholipase A(2) with low catalytic activity: Insights into Ca(2+)-independent catalytic mechanism.
Biochim.Biophys.Acta, 1784, 2008
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3RZX
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3RZ9
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2QOG
 | | Crotoxin B, the basic PLA2 from Crotalus durissus terrificus. | | Descriptor: | CALCIUM ION, Phospholipase A2 CB1, Phospholipase A2 CB2 | | Authors: | Marchi-Salvador, D.P, Correa, L.C, Fontes, M.R.M. | | Deposit date: | 2007-07-20 | | Release date: | 2008-04-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Insights into the role of oligomeric state on the biological activities of crotoxin: crystal structure of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom.
Proteins, 72, 2008
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