7LYE

Myotoxin I from Bothrops moojeni co-crystallized with synthetic inhibitor Varespladib (LY315920)

Summary for 7LYE

• Entry DOI: 10.2210/pdb7lye/pdb
• Related: 3T0R 6CE2 6PWH
• Descriptor: Basic phospholipase A2 homolog BomoTx, ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... (4 entities in total)
• Functional Keywords: myotoxin i, mjtx-i, pla2-like, toxin
• Biological source: Bothrops moojeni (Lance-headed viper, Caissaca)
• Total number of polymer chains: 4
• Total formula weight: 57232.64

Authors

Salvador, G.H.M.,Borges, R.J.,Fontes, M.R.M. (deposition date: 2021-03-06, release date: 2021-05-19, Last modification date: 2023-10-18)

• Primary citation: Salvador, G.H.M.,Borges, R.J.,Lomonte, B.,Lewin, M.R.,Fontes, M.R.M.; The synthetic varespladib molecule is a multi-functional inhibitor for PLA 2 and PLA 2 -like ophidic toxins.; Biochim Biophys Acta Gen Subj, 1865:129913-129913, 2021; PubMed: 33865953; DOI: 10.1016/j.bbagen.2021.129913

Experimental method

X-RAY DIFFRACTION (1.758 Å)