7LYE
Myotoxin I from Bothrops moojeni co-crystallized with synthetic inhibitor Varespladib (LY315920)
Summary for 7LYE
| Entry DOI | 10.2210/pdb7lye/pdb |
| Related | 3T0R 6CE2 6PWH |
| Descriptor | Basic phospholipase A2 homolog BomoTx, ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... (4 entities in total) |
| Functional Keywords | myotoxin i, mjtx-i, pla2-like, toxin |
| Biological source | Bothrops moojeni (Lance-headed viper, Caissaca) |
| Total number of polymer chains | 4 |
| Total formula weight | 57232.64 |
| Authors | Salvador, G.H.M.,Borges, R.J.,Fontes, M.R.M. (deposition date: 2021-03-06, release date: 2021-05-19, Last modification date: 2024-10-23) |
| Primary citation | Salvador, G.H.M.,Borges, R.J.,Lomonte, B.,Lewin, M.R.,Fontes, M.R.M. The synthetic varespladib molecule is a multi-functional inhibitor for PLA 2 and PLA 2 -like ophidic toxins. Biochim Biophys Acta Gen Subj, 1865:129913-129913, 2021 Cited by PubMed Abstract: The treatment for snakebites is early administration of antivenom, which can be highly effective in inhibiting the systemic effects of snake venoms, but is less effective in the treatment of extra-circulatory and local effects. To complement standard-of-care treatments such as antibody-based antivenoms, natural and synthetic small molecules have been proposed for the inhibition of key venom components such as phospholipase A (PLA) and PLA-like toxins. Varespladib (compound LY315920) is a synthetic molecule developed and clinically tested aiming to block inflammatory cascades of several diseases associated with high PLAs. Recent studies have demonstrated this molecule is able to potently inhibit snake venom catalytic PLA and PLA-like toxins. PubMed: 33865953DOI: 10.1016/j.bbagen.2021.129913 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.758 Å) |
Structure validation
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