1EJL
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1EJY
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1PJN
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![BU of 1pjn by Molmil](/molmil-images/mine/1pjn) | Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex | Descriptor: | Histone-binding protein N1/N2, Importin alpha-2 subunit | Authors: | Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. | Deposit date: | 2003-06-03 | Release date: | 2003-08-19 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha J.Biol.Chem., 278, 2003
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1PJM
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![BU of 1pjm by Molmil](/molmil-images/mine/1pjm) | Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex | Descriptor: | Importin alpha-2 subunit, Retinoblastoma-associated protein | Authors: | Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. | Deposit date: | 2003-06-03 | Release date: | 2003-08-19 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha J.Biol.Chem., 278, 2003
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1Q1S
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![BU of 1q1s by Molmil](/molmil-images/mine/1q1s) | Mouse Importin alpha- phosphorylated SV40 CN peptide complex | Descriptor: | Importin alpha-2 subunit, Large T antigen | Authors: | Fontes, M.R.M, Teh, T, Toth, G, John, A, Pavo, I, Jans, D.A, Kobe, B. | Deposit date: | 2003-07-22 | Release date: | 2004-03-30 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha Biochem.J., 375, 2003
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1Q1T
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![BU of 1q1t by Molmil](/molmil-images/mine/1q1t) | Mouse Importin alpha: non-phosphorylated SV40 CN peptide complex | Descriptor: | Importin alpha-2 subunit, Large T antigen | Authors: | Fontes, M.R.M, Teh, T, Toth, G, John, A, Pavo, I, Jans, D.A, Kobe, B. | Deposit date: | 2003-07-22 | Release date: | 2004-03-30 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha Biochem.J., 375, 2003
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1XXS
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![BU of 1xxs by Molmil](/molmil-images/mine/1xxs) | Structural insights for fatty acid binding in a Lys49 phospholipase A2: crystal structure of myotoxin II from Bothrops moojeni complexed with stearic acid | Descriptor: | Phospholipase A2 homolog 2, STEARIC ACID, SULFATE ION | Authors: | Watanabe, L, Soares, A.M, Ward, R.J, Fontes, M.R, Arni, R.K. | Deposit date: | 2004-11-08 | Release date: | 2005-03-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural insights for fatty acid binding in a Lys49-phospholipase A(2): crystal structure of myotoxin II from Bothrops moojeni complexed with stearic acid Biochimie, 87, 2005
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1Z76
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![BU of 1z76 by Molmil](/molmil-images/mine/1z76) | Crystal structure of an acidic phospholipase A2 (BthA-I) from Bothrops jararacussu venom complexed with p-bromophenacyl bromide | Descriptor: | p-Bromophenacyl bromide, phospholipase A2 | Authors: | Magro, A.J, Takeda, A.A, Soares, A.M, Fontes, M.R. | Deposit date: | 2005-03-24 | Release date: | 2006-03-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of BthA-I complexed with p-bromophenacyl bromide: possible correlations with lack of pharmacological activity. Acta Crystallogr.,Sect.D, 61, 2005
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1PA0
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![BU of 1pa0 by Molmil](/molmil-images/mine/1pa0) | CRYSTAL STRUCTURE OF BNSP-7, A LYS49-PHOSPHOLIPASE A2 | Descriptor: | Myotoxic phospholipase A2-like | Authors: | Magro, A.J, Soares, A.M, Giglio, J.R, Fontes, M.R. | Deposit date: | 2003-05-13 | Release date: | 2004-07-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of BnSP-7 and BnSP-6, two Lys49-phospholipases A(2): quaternary structure and inhibition mechanism insights. Biochem.Biophys.Res.Commun., 311, 2003
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1M05
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![BU of 1m05 by Molmil](/molmil-images/mine/1m05) | HLA B8 in complex with an Epstein Barr Virus determinant | Descriptor: | Beta-2-microglobulin, CADMIUM ION, EBNA-3 nuclear protein, ... | Authors: | Kjer-Nielsen, L, Clements, C.S, Brooks, A.G, Purcell, A.W, Fontes, M.R, McCluskey, J, Rossjohn, J. | Deposit date: | 2002-06-11 | Release date: | 2003-09-02 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structure of HLA-B8 complexed to an immunodominant viral determinant: peptide-induced conformational changes and
a mode of MHC class I dimerization. J.IMMUNOL., 169, 2003
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2OK9
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![BU of 2ok9 by Molmil](/molmil-images/mine/2ok9) | PrTX-I-BPB | Descriptor: | ISOPROPYL ALCOHOL, Phospholipase A2 homolog 1, p-Bromophenacyl bromide | Authors: | Marchi-Salvador, D.P, Fernandes, C.A.H, Soares, A.M, Fontes, M.R. | Deposit date: | 2007-01-16 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Crystal structure of a phospholipase A(2) homolog complexed with p-bromophenacyl bromide reveals important structural changes associated with the inhibition of myotoxic activity. Biochim.Biophys.Acta, 1794, 2009
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2Q2J
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1U73
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![BU of 1u73 by Molmil](/molmil-images/mine/1u73) | Crystal structure of a Dimeric Acidic Platelet Aggregation Inhibitor and Hypotensive Phospholipase A2 from Bothrops jararacussu | Descriptor: | hypotensive phospholipase A2 | Authors: | Magro, A.J, Murakami, M.T, Soares, A.M, Arni, R.K, Fontes, M.R. | Deposit date: | 2004-08-02 | Release date: | 2004-10-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of an acidic platelet aggregation inhibitor and hypotensive phospholipase A(2) in the monomeric and dimeric states: insights into its oligomeric state Biochem.Biophys.Res.Commun., 323, 2004
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3CYL
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5U5P
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![BU of 5u5p by Molmil](/molmil-images/mine/5u5p) | Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus Musculus Complexed with a MLH1 NLS Peptide | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DNA mismatch repair protein Mlh1, Importin subunit alpha-1 | Authors: | Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. | Deposit date: | 2016-12-07 | Release date: | 2018-03-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.171 Å) | Cite: | DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 2018
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5U5R
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![BU of 5u5r by Molmil](/molmil-images/mine/5u5r) | Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus musculus Complexed with a PMS2 NLS Peptide | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Importin subunit alpha-1, Mismatch repair endonuclease PMS2 | Authors: | Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. | Deposit date: | 2016-12-07 | Release date: | 2018-03-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 2018
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6X5X
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![BU of 6x5x by Molmil](/molmil-images/mine/6x5x) | Crystal structure o BmooMP-I, a P-I metalloproteinase from Bothrops moojeni | Descriptor: | CALCIUM ION, SULFATE ION, Snake venom metalloproteinase BmooMP-I, ... | Authors: | Salvador, G.H.M, Borges, R.J, Fontes, M.R.M. | Deposit date: | 2020-05-27 | Release date: | 2020-10-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Biochemical, pharmacological and structural characterization of BmooMP-I, a new P-I metalloproteinase from Bothrops moojeni venom. Biochimie, 179, 2020
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7TMX
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7TMY
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8DND
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3CXI
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![BU of 3cxi by Molmil](/molmil-images/mine/3cxi) | Structure of BthTX-I complexed with alpha-tocopherol | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Myotoxic phospholipase A2-like, SULFATE ION, ... | Authors: | dos Santos, J.I, Fontes, M.R.M. | Deposit date: | 2008-04-24 | Release date: | 2009-05-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Comparative structural studies on Lys49-phospholipases A(2) from Bothrops genus reveal their myotoxic site. J.Struct.Biol., 167, 2009
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6P6E
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![BU of 6p6e by Molmil](/molmil-images/mine/6p6e) | Structure of Mouse Importin alpha - PAC3 NLS peptide complex | Descriptor: | Importin subunit alpha-1, PAC3 NLS | Authors: | Bernardes, N.E, Silva, T.D, Fukuda, C.A, Oliveira, H.C, Fontes, M.R.M. | Deposit date: | 2019-06-03 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha. Sci Rep, 10, 2020
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6P6A
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![BU of 6p6a by Molmil](/molmil-images/mine/6p6a) | Structure of Mouse Importin alpha - NIT2 NLS peptide complex | Descriptor: | Importin subunit alpha-1, Nitrogen catabolic enzyme regulatory protein | Authors: | Bernardes, N.E, Fukuda, C.A, Silva, T.D, Oliveira, H.C, Fontes, M.R.M. | Deposit date: | 2019-06-03 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.151 Å) | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha. Sci Rep, 10, 2020
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6PWH
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5EKF
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![BU of 5ekf by Molmil](/molmil-images/mine/5ekf) | |