8DND

Crystal structure of Bothrops pirajai Piratoxin-I (PrTX-I) and synthetic inhibitor Varespladib (LY315920)

Summary for 8DND

• Entry DOI: 10.2210/pdb8dnd/pdb
• Related: 2Q2J 6PWH 7LYE
• Descriptor: Basic phospholipase A2 homolog piratoxin-1, ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: prtx-i, varespladib, bothrops pirajai, pla2-like toxin, toxin, toxin-antitoxin complex, toxin/antitoxin
• Biological source: Bothrops pirajai
• Total number of polymer chains: 2
• Total formula weight: 29033.64

Authors

Salvador, G.H.M.,Fontes, M.R.M. (deposition date: 2022-07-11, release date: 2023-08-02, Last modification date: 2023-08-09)

• Primary citation: Salvador, G.H.M.,Pinto, E.K.R.,Ortolani, P.L.,Fortes-Dias, C.L.,Cavalcante, W.L.G.,Soares, A.M.,Lomonte, B.,Lewin, M.R.,Fontes, M.R.M.; Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib.; Biochimie, 207:1-10, 2023; PubMed: 36403756; DOI: 10.1016/j.biochi.2022.11.006

Experimental method

X-RAY DIFFRACTION (2.018 Å)