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PDB: 75 件
1EJY
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MOUSE IMPORTIN ALPHA-NUCLEOPLASMIN NLS PEPTIDE COMPLEX
分子名称: IMPORTIN ALPHA, NUCLEOPLASMIN NLS PEPTIDE
著者Fontes, M.R, Teh, T, Kobe, B.
登録日2000-03-05
公開日2000-04-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.
J.Mol.Biol., 297, 2000
1EJL
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MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX
分子名称: IMPORTIN ALPHA, SV40 LARGE T ANTIGEN NLS PEPTIDE
著者Fontes, M.R, Teh, T, Kobe, B.
登録日2000-03-03
公開日2000-04-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.
J.Mol.Biol., 297, 2000
1PJN
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Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex
分子名称: Histone-binding protein N1/N2, Importin alpha-2 subunit
著者Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B.
登録日2003-06-03
公開日2003-08-19
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha
J.Biol.Chem., 278, 2003
1PJM
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Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex
分子名称: Importin alpha-2 subunit, Retinoblastoma-associated protein
著者Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B.
登録日2003-06-03
公開日2003-08-19
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha
J.Biol.Chem., 278, 2003
1Q1S
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Mouse Importin alpha- phosphorylated SV40 CN peptide complex
分子名称: Importin alpha-2 subunit, Large T antigen
著者Fontes, M.R.M, Teh, T, Toth, G, John, A, Pavo, I, Jans, D.A, Kobe, B.
登録日2003-07-22
公開日2004-03-30
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha
Biochem.J., 375, 2003
1Q1T
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Mouse Importin alpha: non-phosphorylated SV40 CN peptide complex
分子名称: Importin alpha-2 subunit, Large T antigen
著者Fontes, M.R.M, Teh, T, Toth, G, John, A, Pavo, I, Jans, D.A, Kobe, B.
登録日2003-07-22
公開日2004-03-30
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha
Biochem.J., 375, 2003
6CE2
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Crystal structure of Myotoxin I (MjTX-I) from Bothrops moojeni complexed to inhibitor suramin
分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, Basic phospholipase A2 homolog 1
著者Salvador, G.H.M, Fontes, M.R.M.
登録日2018-02-10
公開日2018-07-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism.
Sci Rep, 8, 2018
4RXH
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Crystal Structure of Importin-alpha from Neurospora crassa complexed with SV40NLS
分子名称: Importin subunit alpha, Large T antigen
著者Bernardes, N.E, Takeda, A.A.S, Fontes, M.R.M.
登録日2014-12-11
公開日2015-07-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.7553 Å)
主引用文献Structure of Importin-alpha from a Filamentous Fungus in Complex with a Classical Nuclear Localization Signal.
Plos One, 10, 2015
7TMX
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Structure of Mouse Importin alpha NEIL1 NLS Peptide Complex
分子名称: Importin subunit alpha-1, Nuclear Localization Signal from Endonuclease 8-like 1
著者Moraes, I.R, de Oliveira, H.C, Fontes, M.R.M.
登録日2022-01-20
公開日2023-08-02
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis of nuclear transport for NEIL DNA glycosylases mediated by importin-alpha.
Biochim Biophys Acta Proteins Proteom, 1872, 2023
7TMY
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Structure of Mouse Importin alpha NEIL3 NLS Peptide Complex
分子名称: Importin subunit alpha-1, Nuclear Localization Signal from Endonuclease 8-like 3
著者Moraes, I.R, de Oliveira, H.C, Fontes, M.R.M.
登録日2022-01-20
公開日2023-08-02
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structural basis of nuclear transport for NEIL DNA glycosylases mediated by importin-alpha.
Biochim Biophys Acta Proteins Proteom, 1872, 2023
6X5X
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Crystal structure o BmooMP-I, a P-I metalloproteinase from Bothrops moojeni
分子名称: CALCIUM ION, SULFATE ION, Snake venom metalloproteinase BmooMP-I, ...
著者Salvador, G.H.M, Borges, R.J, Fontes, M.R.M.
登録日2020-05-27
公開日2020-10-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Biochemical, pharmacological and structural characterization of BmooMP-I, a new P-I metalloproteinase from Bothrops moojeni venom.
Biochimie, 179, 2020
6WBA
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Structure of Mouse Importin alpha MLH1- R470A NLS Peptide Complex
分子名称: DNA mismatch repair protein Mlh1, Importin subunit alpha-1
著者de Barros, A.C, da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M.
登録日2020-03-26
公開日2021-07-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.151 Å)
主引用文献Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Biochem.J., 478, 2021
6WBB
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Structure of Mouse Importin alpha - MLH1-E475A NLS peptide complex
分子名称: DNA mismatch repair protein Mlh1, Importin subunit alpha-1
著者De Barros, A.C, Da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M.
登録日2020-03-26
公開日2021-07-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.663 Å)
主引用文献Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Biochem.J., 478, 2021
6WBC
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Structure of Mouse Importin alpha- MLH1-R472K NLS Peptide Complex
分子名称: DNA mismatch repair protein Mlh1, Importin subunit alpha-1
著者de Barros, A.C, da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M.
登録日2020-03-26
公開日2021-07-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Biochem.J., 478, 2021
6P6E
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Structure of Mouse Importin alpha - PAC3 NLS peptide complex
分子名称: Importin subunit alpha-1, PAC3 NLS
著者Bernardes, N.E, Silva, T.D, Fukuda, C.A, Oliveira, H.C, Fontes, M.R.M.
登録日2019-06-03
公開日2020-01-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha.
Sci Rep, 10, 2020
6P6A
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Structure of Mouse Importin alpha - NIT2 NLS peptide complex
分子名称: Importin subunit alpha-1, Nitrogen catabolic enzyme regulatory protein
著者Bernardes, N.E, Fukuda, C.A, Silva, T.D, Oliveira, H.C, Fontes, M.R.M.
登録日2019-06-03
公開日2020-01-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.151 Å)
主引用文献Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha.
Sci Rep, 10, 2020
6MQF
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Myotoxin II from Bothrops moojeni complexed with Acetylsalicylic acid
分子名称: 2-(ACETYLOXY)BENZOIC ACID, Basic phospholipase A2 homolog 2, DIMETHYL SULFOXIDE
著者Salvador, G.H.M, Fontes, M.R.M.
登録日2018-10-09
公開日2019-03-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.693 Å)
主引用文献Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A2-like proteins using functional, structural and bioinformatics approaches.
Sci Rep, 9, 2019
6MQD
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Myotoxin II from Bothrops moojeni complexed with Rosmarinic Acid
分子名称: (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid, Basic phospholipase A2 homolog 2
著者Salvador, G.H.M, Fontes, M.R.M.
登録日2018-10-09
公開日2019-03-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A2-like proteins using functional, structural and bioinformatics approaches.
Sci Rep, 9, 2019
8DND
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BU of 8dnd by Molmil
Crystal structure of Bothrops pirajai Piratoxin-I (PrTX-I) and synthetic inhibitor Varespladib (LY315920)
分子名称: ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid, Basic phospholipase A2 homolog piratoxin-1, SULFATE ION
著者Salvador, G.H.M, Fontes, M.R.M.
登録日2022-07-11
公開日2023-08-02
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.018 Å)
主引用文献Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib.
Biochimie, 207, 2023
3CXI
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Structure of BthTX-I complexed with alpha-tocopherol
分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Myotoxic phospholipase A2-like, SULFATE ION, ...
著者dos Santos, J.I, Fontes, M.R.M.
登録日2008-04-24
公開日2009-05-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Comparative structural studies on Lys49-phospholipases A(2) from Bothrops genus reveal their myotoxic site.
J.Struct.Biol., 167, 2009
3CYL
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Crystal structure of Piratoxin I (a myotoxic Lys49-PLA2) complexed with alpha-tocopherol
分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Phospholipase A2 homolog 2, SULFATE ION, ...
著者dos Santos, J.I, Fontes, M.R.M.
登録日2008-04-25
公開日2009-05-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Comparative structural studies on Lys49-phospholipases A(2) from Bothrops genus reveal their myotoxic site.
J.Struct.Biol., 167, 2009
5EKG
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Crystallization and X-ray Diffraction Data Collection of Importin-alpha from Mus musculus Complexed with a XPG NLS Peptide, fragment 2
分子名称: Importin subunit alpha-1, XPG2 peptide
著者Barros, A.C, Takeda, A.A.S, Fontes, M.R.M.
登録日2015-11-03
公開日2016-02-10
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and Calorimetric Studies Demonstrate that Xeroderma Pigmentosum Type G (XPG) Can Be Imported to the Nucleus by a Classical Nuclear Import Pathway via a Monopartite NLS Sequence.
J.Mol.Biol., 428, 2016
5EKF
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Crystallization and X-ray Diffraction Data Collection of Importin-alpha from Mus musculus Complexed with a XPG NLS Peptide, fragment 1
分子名称: DNA repair protein complementing XP-G cells, Importin subunit alpha-1
著者Barros, A.C, Takeda, A.A.S, Fontes, M.R.M.
登録日2015-11-03
公開日2016-02-10
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and Calorimetric Studies Demonstrate that Xeroderma Pigmentosum Type G (XPG) Can Be Imported to the Nucleus by a Classical Nuclear Import Pathway via a Monopartite NLS Sequence.
J.Mol.Biol., 428, 2016
4YU7
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Crystal structure of Piratoxin I (PrTX-I) complexed to caffeic acid
分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Basic phospholipase A2 homolog piratoxin-1, CAFFEIC ACID, ...
著者Fernandes, C.A.H, Fontes, M.R.M.
登録日2015-03-18
公開日2015-08-05
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.647 Å)
主引用文献Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids.
Plos One, 10, 2015
5VFM
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Crystal structure of BnSP-7 from Bothrops pauloensis complexed with p-coumaric acid
分子名称: 1-ETHOXY-2-(2-METHOXYETHOXY)ETHANE, 4'-HYDROXYCINNAMIC ACID, Basic phospholipase A2 homolog BnSP-7, ...
著者De Lima, L.F.G, Fontes, M.R.M.
登録日2017-04-08
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.058 Å)
主引用文献Structural studies with BnSP-7 reveal an atypical oligomeric conformation compared to phospholipases A2-like toxins.
Biochimie, 142, 2017

 

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