5JWP
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![BU of 5jwp by Molmil](/molmil-images/mine/5jwp) | Crystal structure of human FIH D201E variant in complex with Zn, alpha-ketoglutarate, and HIF1 alpha peptide. | 分子名称: | 2-OXOGLUTARIC ACID, GLYCEROL, Hypoxia-inducible factor 1-alpha, ... | 著者 | Taabazuing, C.Y, Garman, S.C, Eron, S, Knapp, M.J. | 登録日 | 2016-05-12 | 公開日 | 2016-11-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The facial triad in the alpha-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation. J.Inorg.Biochem., 166, 2016
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7AA9
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![BU of 7aa9 by Molmil](/molmil-images/mine/7aa9) | Structure of SCOC pT13/pT15 LIR motif bound to GABARAPL1 | 分子名称: | Gamma-aminobutyric acid receptor-associated protein-like 1, pT13/PT15 SCOC LIR | 著者 | Lee, R, Mouilleron, S, Wirth, M, Zhang, W, O Reilly, N, Dhira, J, Tooze, S. | 登録日 | 2020-09-03 | 公開日 | 2021-06-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity. J.Mol.Biol., 433, 2021
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7AA8
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![BU of 7aa8 by Molmil](/molmil-images/mine/7aa8) | Structure of SCOC LIR bound to GABARAP | 分子名称: | Chimera made of SCOC (6-23) + linker (GS) + GABARAP,Gamma-aminobutyric acid receptor-associated protein | 著者 | Lee, R, Mouilleron, S, Wirth, M, Zhang, W, O Reilly, N, Dhira, J, Tooze, S. | 登録日 | 2020-09-03 | 公開日 | 2021-06-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity. J.Mol.Biol., 433, 2021
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7AA7
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![BU of 7aa7 by Molmil](/molmil-images/mine/7aa7) | Structure of SCOC pS12/pS18 LIR motif bound to GABARAPL1 | 分子名称: | Gamma-aminobutyric acid receptor-associated protein-like 1, pS12/pS18 SCOC LIR, sulfoacetic acid | 著者 | Lee, R, Mouilleron, S, Wirth, M, Zhang, W, O Reilly, N, Dhira, J, Tooze, S. | 登録日 | 2020-09-03 | 公開日 | 2021-06-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity. J.Mol.Biol., 433, 2021
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5FM2
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![BU of 5fm2 by Molmil](/molmil-images/mine/5fm2) | Crystal structure of hyper-phosphorylated RET kinase domain with (proximal) juxtamembrane segment | 分子名称: | 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | 著者 | Plaza-Menacho, I, Barnouin, K, Barry, R, Borg, A, Orme, M, Mouilleron, S, Martinez-Torres, R.J, Meier, P, McDonald, N.Q. | 登録日 | 2015-10-30 | 公開日 | 2016-12-28 | 最終更新日 | 2019-04-24 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements. Cell Rep, 17, 2016
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5FM3
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![BU of 5fm3 by Molmil](/molmil-images/mine/5fm3) | Crystal structure of hyper-phosphorylated RET kinase domain with (proximal) juxtamembrane segment | 分子名称: | 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | 著者 | Plaza-Menacho, I, Barnouin, K, Barry, R, Borg, A, Orme, M, Mouilleron, S, Martinez-Torres, R.J, Meier, P, McDonald, N.Q. | 登録日 | 2015-10-30 | 公開日 | 2016-12-28 | 最終更新日 | 2019-04-24 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements. Cell Rep, 17, 2016
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2BNM
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![BU of 2bnm by Molmil](/molmil-images/mine/2bnm) | |
2BNO
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![BU of 2bno by Molmil](/molmil-images/mine/2bno) | The structure of Hydroxypropylphosphonic acid epoxidase from S. wedmorenis. | 分子名称: | EPOXIDASE, MERCURY (II) ION, SULFATE ION, ... | 著者 | McLuskey, K, Cameron, S, Hunter, W.N. | 登録日 | 2005-03-29 | 公開日 | 2005-10-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure and Reactivity of Hydroxypropylphosphonic Acid Epoxidase in Fosfomycin Biosynthesis by a Cation- and Flavin-Dependent Mechanism. Proc.Natl.Acad.Sci.USA, 102, 2005
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2BNN
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![BU of 2bnn by Molmil](/molmil-images/mine/2bnn) | |
6GE9
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![BU of 6ge9 by Molmil](/molmil-images/mine/6ge9) | Structure of Mycobacterium tuberculosis GlmU bound to Glc-1P and Ac-CoA | 分子名称: | 1,2-ETHANEDIOL, 1-O-phosphono-alpha-D-glucopyranose, ACETYL COENZYME *A, ... | 著者 | Craggs, P.D, Mouilleron, S, Rejzek, M, de Chiara, C, Young, R.J, Field, R.A, Argyrou, A, de Carvalho, L.P.S. | 登録日 | 2018-04-25 | 公開日 | 2018-05-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | The Mechanism of Acetyl Transfer Catalyzed by Mycobacterium tuberculosis GlmU. Biochemistry, 57, 2018
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2X75
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![BU of 2x75 by Molmil](/molmil-images/mine/2x75) | Staphylococcus aureus adenylosuccinate lyase | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENYLOSUCCINATE LYASE, CHLORIDE ION, ... | 著者 | Fyfe, P.K, Dawson, A, Hutchison, M.T, Cameron, S, Hunter, W.N. | 登録日 | 2010-02-23 | 公開日 | 2010-03-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of Staphylococcus Aureus Adenylosuccinate Lyase (Purb) and Assessment of its Potential as a Target for Structure-Based Inhibitor Discovery. Acta Crystallogr.,Sect.D, 66, 2010
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4A26
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![BU of 4a26 by Molmil](/molmil-images/mine/4a26) | The crystal structure of Leishmania major N5,N10- methylenetetrahydrofolate dehydrogenase/cyclohydrolase | 分子名称: | CHLORIDE ION, PUTATIVE C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC | 著者 | Eadsforth, T.C, Cameron, S, Hunter, W.N. | 登録日 | 2011-09-22 | 公開日 | 2011-10-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The Crystal Structure of Leishmania Major N(5),N(10)-Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase and Assessment of a Potential Drug Target. Mol.Biochem.Parasitol., 181, 2012
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2WTA
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![BU of 2wta by Molmil](/molmil-images/mine/2wta) | Acinetobacter baumanii nicotinamidase pyrazinamidease | 分子名称: | CHLORIDE ION, GLYCEROL, NICOTINAMIDASE, ... | 著者 | Fyfe, P.K, Rao, V.A, Zemla, A, Cameron, S, Hunter, W.N. | 登録日 | 2009-09-15 | 公開日 | 2009-11-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Specificity and Mechanism of Acinetobacter Baumanii Nicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide. Angew.Chem.Int.Ed.Engl., 48, 2009
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2WT9
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![BU of 2wt9 by Molmil](/molmil-images/mine/2wt9) | Acinetobacter baumanii nicotinamidase pyrazinamidease | 分子名称: | GLYCEROL, NICOTINAMIDASE, NICOTINIC ACID, ... | 著者 | Fyfe, P.K, Rao, V.A, Zemla, A, Cameron, S, Hunter, W.N. | 登録日 | 2009-09-15 | 公開日 | 2009-11-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Specificity and Mechanism of Acinetobacter Baumanii Nicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide. Angew.Chem.Int.Ed.Engl., 48, 2009
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4CKJ
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![BU of 4ckj by Molmil](/molmil-images/mine/4ckj) | Crystal structure of RET tyrosine kinase domain bound to adenosine | 分子名称: | ADENOSINE, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | 著者 | Plaza-Menacho, I, Barnouin, K, Goodman, K, Martinez-Torres, R.J, Borg, A, Murray-Rust, J, Mouilleron, S, Knowles, P, McDonald, N.Q. | 登録日 | 2014-01-06 | 公開日 | 2014-03-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans. Mol. Cell, 53, 2014
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4CKI
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![BU of 4cki by Molmil](/molmil-images/mine/4cki) | Crystal Structure of oncogenic RET tyrosine kinase M918T bound to adenosine | 分子名称: | ADENOSINE, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | 著者 | Plaza-Menacho, I, Barnouin, K, Goodman, K, Martinez-Torres, R.J, Borg, A, Murray-Rust, J, Mouilleron, S, Knowles, P, McDonald, N.Q. | 登録日 | 2014-01-06 | 公開日 | 2014-03-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.116 Å) | 主引用文献 | Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans. Mol. Cell, 53, 2014
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