5LPM
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![BU of 5lpm by Molmil](/molmil-images/mine/5lpm) | Crystal structure of the bromodomain of human Ep300 bound to the inhibitor XDM3d | Descriptor: | ACETATE ION, Histone acetyltransferase p300, ~{N}-[(1~{S},2~{S})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole -2-carboxamide | Authors: | Huegle, M, Wohlwend, D, Gerhardt, S. | Deposit date: | 2016-08-13 | Release date: | 2017-08-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56, 2017
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5LC9
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8PFH
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![BU of 8pfh by Molmil](/molmil-images/mine/8pfh) | Crystal structure of the yeast septin complex Shs1-Cdc12-Cdc3-Cdc10 | Descriptor: | CDC10 isoform 1, CDC12 isoform 1, Cell division control protein 3, ... | Authors: | Grupp, B, Denkhaus, L, Gerhardt, S, Gronemeyer, T. | Deposit date: | 2023-06-16 | Release date: | 2023-12-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.24 Å) | Cite: | The structure of a tetrameric septin complex reveals a hydrophobic element essential for NC-interface integrity. Commun Biol, 7, 2024
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1PKV
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![BU of 1pkv by Molmil](/molmil-images/mine/1pkv) | The N-terminal domain of riboflavin synthase in complex with riboflavin | Descriptor: | RIBOFLAVIN, Riboflavin synthase alpha chain | Authors: | Meining, W, Eberhardt, S, Bacher, A, Ladenstein, R. | Deposit date: | 2003-06-06 | Release date: | 2004-06-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolution. J.Mol.Biol., 331, 2003
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4IXC
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1P0K
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![BU of 1p0k by Molmil](/molmil-images/mine/1p0k) | IPP:DMAPP isomerase type II apo structure | Descriptor: | Isopentenyl-diphosphate delta-isomerase, PHOSPHATE ION | Authors: | Steinbacher, S, Kaiser, J, Gerhardt, S, Eisenreich, W, Huber, R, Bacher, A, Rohdich, F. | Deposit date: | 2003-04-10 | Release date: | 2003-06-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase from Bacillus subtilis J.Mol.Biol., 329, 2003
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1P0N
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![BU of 1p0n by Molmil](/molmil-images/mine/1p0n) | IPP:DMAPP isomerase type II, FMN complex | Descriptor: | FLAVIN MONONUCLEOTIDE, Isopentenyl-diphosphate delta-isomerase | Authors: | Steinbacher, S, Kaiser, J, Gerhardt, S, Eisenreich, W, Huber, R, Bacher, A, Rohdich, F. | Deposit date: | 2003-04-10 | Release date: | 2003-06-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase from Bacillus subtilis J.Mol.Biol., 329, 2003
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5O6M
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4L4Q
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![BU of 4l4q by Molmil](/molmil-images/mine/4l4q) | Methionine Adenosyltransferase | Descriptor: | S-adenosylmethionine synthase | Authors: | Schlesier, J, Siegrist, J, Gerhardt, S, Andexer, J.N, Einsle, O. | Deposit date: | 2013-06-09 | Release date: | 2014-03-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis. Bmc Struct.Biol., 13, 2013
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5O6K
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2XQB
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![BU of 2xqb by Molmil](/molmil-images/mine/2xqb) | Crystal Structure of anti-IL-15 Antibody in Complex with human IL-15 | Descriptor: | ANTI-IL-15 ANTIBODY, INTERLEUKIN 15, SULFATE ION | Authors: | Lowe, D.C, Gerhardt, S, Ward, A, Hargreaves, D, Anderson, M, StGallay, S, Vousden, K, Ferraro, F, Pauptit, R.A, Cochrane, D, Pattison, D.V, Buchanan, C, Popovic, B, Finch, D.K, Wilkinson, T, Sleeman, M, Vaughan, T.J, Cruwys, S, Mallinder, P.R. | Deposit date: | 2010-09-01 | Release date: | 2010-12-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Engineering a High Affinity Anti-Il-15 Antibody: Crystal Structure Reveals an Alpha-Helix in Vh Cdr3 as Key Component of Paratope. J.Mol.Biol., 406, 2011
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5D25
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![BU of 5d25 by Molmil](/molmil-images/mine/5d25) | First bromodomain of BRD4 bound to inhibitor XD27 | Descriptor: | (R,R)-2,3-BUTANEDIOL, 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3,5-dimethyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4, ... | Authors: | Wohlwend, D, Huegle, M, Gerhardt, S. | Deposit date: | 2015-08-05 | Release date: | 2016-01-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
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4LYW
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![BU of 4lyw by Molmil](/molmil-images/mine/4lyw) | Crystal Structure of BRD4(1) bound to inhibitor XD14 | Descriptor: | 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 | Authors: | Wohlwend, D, Gerhardt, S, Einsle, O. | Deposit date: | 2013-07-31 | Release date: | 2014-01-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52, 2013
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4LZR
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![BU of 4lzr by Molmil](/molmil-images/mine/4lzr) | Crystal Structure of BRD4(1) bound to Colchicine | Descriptor: | Bromodomain-containing protein 4, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide | Authors: | Wohlwend, D, Gerhardt, S, Einsle, O, Huegle, M. | Deposit date: | 2013-08-01 | Release date: | 2014-01-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52, 2013
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4LZS
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![BU of 4lzs by Molmil](/molmil-images/mine/4lzs) | Crystal Structure of BRD4(1) bound to inhibitor XD46 | Descriptor: | 4-acetyl-3-ethyl-N,5-dimethyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 | Authors: | Wohlwend, D, Huegle, M, Einsle, O, Gerhardt, S. | Deposit date: | 2013-08-01 | Release date: | 2014-01-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52, 2013
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5D24
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![BU of 5d24 by Molmil](/molmil-images/mine/5d24) | First bromodomain of BRD4 bound to inhibitor XD26 | Descriptor: | 1,2-ETHANEDIOL, 4-acetyl-N-[3-(2-amino-2-oxoethoxy)phenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 | Authors: | Wohlwend, D, Huegle, M, Gerhardt, S. | Deposit date: | 2015-08-05 | Release date: | 2016-01-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
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3JT1
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![BU of 3jt1 by Molmil](/molmil-images/mine/3jt1) | Legionella pneumophila glucosyltransferase Lgt1, UDP-bound form | Descriptor: | Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE | Authors: | Lu, W, Du, J, Belyi, Y, Stahl, M, Zivilikidis, T, Gerhardt, S, Aktories, K, Einsle, O. | Deposit date: | 2009-09-11 | Release date: | 2010-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila. J.Mol.Biol., 2009
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4LYS
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![BU of 4lys by Molmil](/molmil-images/mine/4lys) | Crystal Structure of BRD4(1) bound to Colchiceine | Descriptor: | Bromodomain-containing protein 4, N-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide, SODIUM ION | Authors: | Wohlwend, D, Gerhardt, S, Einsle, O. | Deposit date: | 2013-07-31 | Release date: | 2014-01-15 | Last modified: | 2014-01-29 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl., 52, 2013
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1HZE
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![BU of 1hze by Molmil](/molmil-images/mine/1hze) | SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF RIBOFLAVIN SYNTHASE FROM E. COLI | Descriptor: | RIBOFLAVIN, RIBOFLAVIN SYNTHASE ALPHA CHAIN | Authors: | Truffault, V, Coles, M, Diercks, T, Abelmann, K, Eberhardt, S, Luettgen, H, Bacher, A, Kessler, H. | Deposit date: | 2001-01-24 | Release date: | 2001-09-05 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | The solution structure of the N-terminal domain of riboflavin synthase. J.Mol.Biol., 309, 2001
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1I18
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![BU of 1i18 by Molmil](/molmil-images/mine/1i18) | SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF RIBOFLAVIN SYNTHASE FROM E. COLI | Descriptor: | RIBOFLAVIN, RIBOFLAVIN SYNTHASE ALPHA CHAIN | Authors: | Truffault, V, Coles, M, Diercks, T, Abelmann, K, Eberhardt, S, Luettgen, H, Bacher, A, Kessler, H. | Deposit date: | 2001-01-31 | Release date: | 2001-09-05 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | The solution structure of the N-terminal domain of riboflavin synthase. J.Mol.Biol., 309, 2001
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5AR1
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![BU of 5ar1 by Molmil](/molmil-images/mine/5ar1) | Crystal structure of Cdc11 from Saccharomyces cerevisiae | Descriptor: | CELL DIVISION CONTROL PROTEIN 11 | Authors: | Brausemann, A, Gerhardt, S, Schott, A.K, Einsle, O, Grosse-Berkenbusch, A, Johnsson, N, Gronemeyer, T. | Deposit date: | 2015-09-23 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Crystal Structure of Cdc11, a Septin Subunit from Saccharomyces Cerevisiae. J.Struct.Biol., 193, 2016
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2A57
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![BU of 2a57 by Molmil](/molmil-images/mine/2a57) | Structure of 6,7-Dimthyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 6-carboxyethyl-7-oxo-8-ribityllumazine | Descriptor: | 3-[8-((2S,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL)-2,4,7-TRIOXO-1,3,8-TRIHYDROPTERIDIN-6-YL]PROPANOIC ACID, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | Authors: | Koch, M, Breithaupt, C, Gerhardt, S, Haase, I, Weber, S, Cushman, M, Huber, R, Bacher, A, Fischer, M. | Deposit date: | 2005-06-30 | Release date: | 2005-07-19 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase Eur.J.Biochem., 271, 2004
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2A59
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![BU of 2a59 by Molmil](/molmil-images/mine/2a59) | Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 5-nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidinedione | Descriptor: | 5-NITROSO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | Authors: | Koch, M, Breithaupt, C, Gerhardt, S, Haase, I, Weber, S, Cushman, M, Huber, R, Bacher, A, Fischer, M. | Deposit date: | 2005-06-30 | Release date: | 2005-07-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase Eur.J.Biochem., 271, 2004
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2A58
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![BU of 2a58 by Molmil](/molmil-images/mine/2a58) | Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound riboflavin | Descriptor: | 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION, RIBOFLAVIN | Authors: | Koch, M, Breithaupt, C, Gerhardt, S, Haase, I, Weber, S, Cushman, M, Huber, R, Bacher, A, Fischer, M. | Deposit date: | 2005-06-30 | Release date: | 2005-07-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase Eur.J.Biochem., 271, 2004
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3JSZ
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![BU of 3jsz by Molmil](/molmil-images/mine/3jsz) | Legionella pneumophila glucosyltransferase Lgt1 N293A with UDP-Glc | Descriptor: | MAGNESIUM ION, Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE-GLUCOSE | Authors: | Lu, W, Du, J, Belyi, Y, Stahl, M, Zivilikidis, T, Gerhardt, S, Aktories, K, Einsle, O. | Deposit date: | 2009-09-11 | Release date: | 2010-02-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila. J.Mol.Biol., 2009
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