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PDB: 130 results
5WHJ
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BU of 5whj by Molmil
Crystal structure of Fab fragment of anti-FcRn antibody DX-2507
Descriptor: DX-2507 Fab heavy chain, DX-2507 Fab light chain
Authors:Edwards, T.E, Fairman, J.W, Nixon, A.E, Kenniston, J.A.
Deposit date:2017-07-17
Release date:2017-09-06
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.
J. Biol. Chem., 292, 2017
5WHK
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BU of 5whk by Molmil
Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M
Descriptor: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Beta-2-microglobulin, ...
Authors:Edwards, T.E, Clifton, M.C, Nixon, A.E, Kenniston, J.A.
Deposit date:2017-07-17
Release date:2017-09-06
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.
J. Biol. Chem., 292, 2017
6AQ3
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BU of 6aq3 by Molmil
Crystal structure of a trafficking protein particle complex subunit 3 from Naegleria fowleri covalently bound to palmitic acid
Descriptor: 1,2-ETHANEDIOL, PALMITIC ACID, trafficking protein particle complex subunit 3
Authors:Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-08-18
Release date:2017-08-30
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of a trafficking protein particle complex subunit 3 from Naegleria fowleri covalently bound to palmitic acid
To Be Published
6AY1
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BU of 6ay1 by Molmil
Crystal structure of a nucleoside diphosphate kinase NDK from Helicobacter pylori
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, HEXANE-1,6-DIOL, ISOPROPYL ALCOHOL, ...
Authors:Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-09-07
Release date:2017-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of a nucleoside diphosphate kinase NDK from Helicobacter pylori
To be Published
6UGK
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BU of 6ugk by Molmil
CRYSTAL STRUCTURE OF CIRCULARLY PERMUTED HUMAN TASPASE-1
Descriptor: CHLORIDE ION, SODIUM ION, Threonine aspartase 1,Threonine aspartase 1
Authors:Edwards, T.E, Delker, S.L.
Deposit date:2019-09-26
Release date:2021-03-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural insights into the function of the catalytically active human Taspase1.
Structure, 29, 2021
4E7A
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BU of 4e7a by Molmil
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin deletion bound to primer-template RNA with a 2',3'-ddC
Descriptor: 5'-R(*CP*AP*UP*GP*GP*C)-D(P*(DOC))-3', RNA-directed RNA polymerase
Authors:Edwards, T.E, Mosley, R.T.
Deposit date:2012-03-16
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4E76
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BU of 4e76 by Molmil
Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion
Descriptor: 1,2-ETHANEDIOL, RNA-directed RNA polymerase, SULFATE ION
Authors:Edwards, T.E, Mosley, R.T.
Deposit date:2012-03-16
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4E78
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BU of 4e78 by Molmil
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG
Descriptor: 5'-R(*U*AP*CP*CP*GP*(GDO))-3', PROTEIN (RNA-directed RNA polymerase)
Authors:Edwards, T.E, Mosley, R.T.
Deposit date:2012-03-16
Release date:2012-04-18
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4EYE
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BU of 4eye by Molmil
Crystal structure of a probable oxidoreductase from Mycobacterium abscessus solved by iodide ion SAD
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Probable oxidoreductase
Authors:Edwards, T.E, Abendroth, J, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-05-01
Release date:2012-05-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
5UJ2
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BU of 5uj2 by Molmil
Crystal structure of HCV NS5B genotype 2A JFH-1 isolate with S15G E86Q E87Q C223H V321I mutations and Delta8 neta hairpoin loop deletion in complex with GS-639476 (diphsohate version of GS-9813), Mn2+ and symmetrical primer template 5'-AUAAAUUU
Descriptor: (1S)-1-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-1,4-anhydro-2-deoxy-2-fluoro-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-2-methyl-D-ribitol, CHLORIDE ION, Genome polyprotein, ...
Authors:Edwards, T.E, Fox III, D, Appleby, T.C, Murakami, E, Rey, A, McGrath, M.E.
Deposit date:2017-01-16
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Bioorg. Med. Chem. Lett., 27, 2017
5TQJ
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BU of 5tqj by Molmil
Crystal structure of response regulator receiver protein from Burkholderia phymatum
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Response regulator receiver protein
Authors:Edwards, T.E, Dranow, D.M, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2016-10-24
Release date:2016-11-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of response regulator receiver protein from Burkholderia phymatum
To Be Published
3TE8
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BU of 3te8 by Molmil
Crystal structure of risS periplasmic domain at low pH dimer with N-termini ordered
Descriptor: Sensor histidine kinase RisS
Authors:Edwards, T.E, Abendroth, J, Labiuk, S.L, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-08-12
Release date:2011-08-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of risS periplasmic domain at low pH dimer with N-termini ordered
To be Published
3OT0
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BU of 3ot0 by Molmil
Crystal structure of a DNA containing the rigid nitroxide spin-labeled nucleotide C-spin
Descriptor: Spin-labeled DNA
Authors:Edwards, T.E.
Deposit date:2010-09-10
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7004 Å)
Cite:Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe C.
Nucleic Acids Res., 10, 2011
2HOK
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BU of 2hok by Molmil
Crystal structure of an E. coli thi-box riboswitch bound to thiamine pyrophosphate, calcium ions
Descriptor: CALCIUM ION, THIAMINE DIPHOSPHATE, thi-box riboswitch
Authors:Edwards, T.E, Ferre-D'Amare, A.R.
Deposit date:2006-07-14
Release date:2006-09-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
4OGY
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BU of 4ogy by Molmil
Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution
Descriptor: 1,2-ETHANEDIOL, DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, ...
Authors:Edwards, T.E, Clifton, M.C, Abendroth, J, Nixon, A, Ladner, R.
Deposit date:2014-01-16
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition of plasma kallikrein by a highly specific active site blocking antibody.
J.Biol.Chem., 289, 2014
4WTD
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BU of 4wtd by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH ADP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MANGANESE (II) ION, ...
Authors:Edwards, T.E, Fox III, D, Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTF
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BU of 4wtf by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GS-639475, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU
Descriptor: 2'-C-methyluridine 5'-(trihydrogen diphosphate), CHLORIDE ION, MANGANESE (II) ION, ...
Authors:Edwards, T.E, Appleby, T.C, Mcgrath, M.E.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTJ
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BU of 4wtj by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-AUCC, RNA PRIMER 5'-PGG, MN2+, AND ADP
Descriptor: 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTM
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BU of 4wtm by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-UAGG, RNA PRIMER 5'-PCC, MN2+, AND UDP
Descriptor: CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER CC, ...
Authors:Edwards, T.E, Appleby, T.C, Fox III, D.
Deposit date:2014-10-30
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
2HOM
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BU of 2hom by Molmil
Crystal structure of an E. coli thi-box riboswitch bound to thiamine monophosphate
Descriptor: CALCIUM ION, MAGNESIUM ION, THIAMIN PHOSPHATE, ...
Authors:Edwards, T.E, Ferre-D'Amare, A.R.
Deposit date:2006-07-14
Release date:2006-09-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
2HOL
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BU of 2hol by Molmil
Crystal structure of an E. coli thi-box riboswitch bound to thiamine pyrophosphate, barium ions
Descriptor: BARIUM ION, CALCIUM ION, MAGNESIUM ION, ...
Authors:Edwards, T.E, Ferre-D'Amare, A.R.
Deposit date:2006-07-14
Release date:2006-09-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
4WT9
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BU of 4wt9 by Molmil
APO CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH E86Q E87Q S15G C223H V321I AND DELTA8 MUTATIONS
Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTA
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BU of 4wta by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH UDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU
Descriptor: CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER TEMPLATE CAAAAUUU, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTC
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BU of 4wtc by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH CDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AGAAAUUU
Descriptor: CHLORIDE ION, CYTIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTE
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BU of 4wte by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-ACAAAUUU
Descriptor: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Edwards, T.E, Appleby, T.C.
Deposit date:2014-10-29
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015

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