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PDB: 480 件
6V2U
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BU of 6v2u by Molmil
Crystal structure of the insect cell-expressed WT-BRAF kinase in complex with Dabrafenib
分子名称: CHLORIDE ION, Dabrafenib, Serine/threonine-protein kinase B-raf
著者Li, K, Gonzalez Del-Pino, G, Park, E, Eck, M.J.
登録日2019-11-25
公開日2020-12-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.78 Å)
主引用文献Crystal structure of the insect cell-expressed WT-BRAF kinase in complex with Dabrafenib
To Be Published
1UX5
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BU of 1ux5 by Molmil
Crystal Structures of a Formin Homology-2 domain reveal a flexibly tethered dimer architecture
分子名称: BNI1 PROTEIN
著者Xu, Y, Moseley, J.B, Sagot, I, Poy, F, Pellman, D, Goode, B.L, Eck, M.J.
登録日2004-02-19
公開日2004-03-11
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structures of a Formin Homology-2 Domain Reveal a Tethered Dimer Architecture
Cell(Cambridge,Mass.), 116, 2004
7JXP
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BU of 7jxp by Molmil
EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-04-125-02
分子名称: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
著者Beyett, T.S, Eck, M.J.
登録日2020-08-27
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7JXM
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BU of 7jxm by Molmil
EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045
分子名称: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
著者Beyett, T.S, Eck, M.J.
登録日2020-08-27
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.192 Å)
主引用文献Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7JXK
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BU of 7jxk by Molmil
EGFR kinase (T790M/V948R) in complex with PF-06747775 and JBJ-04-125-02
分子名称: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
著者Beyett, T.S, Eck, M.J.
登録日2020-08-27
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7K1H
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BU of 7k1h by Molmil
EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063
分子名称: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
著者Beyett, T.S, Eck, M.J.
登録日2020-09-07
公開日2021-09-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.602 Å)
主引用文献Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7JXW
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BU of 7jxw by Molmil
EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063
分子名称: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
著者Beyett, T.S, Eck, M.J.
登録日2020-08-28
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
1U5F
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BU of 1u5f by Molmil
Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues
分子名称: SULFATE ION, Src-associated adaptor protein
著者Tang, Y, Swanson, K.D, Neel, B.G, Eck, M.J.
登録日2004-07-27
公開日2005-07-26
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for the Dimerization and Phosphoinositide Specificity of the Src Kinase-associated Phosphoproteins SKAP55 and SKAP-Hom
To be Published
1U5G
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BU of 1u5g by Molmil
Crystal Structure of the PH Domain of SKAP-Hom
分子名称: Src-associated adaptor protein
著者Tang, Y, Swanson, K, Neel, B.G, Eck, M.J.
登録日2004-07-27
公開日2005-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.
Mol.Cell, 32, 2008
1B47
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BU of 1b47 by Molmil
STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70
分子名称: CALCIUM ION, CBL
著者Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
登録日1999-01-06
公開日1999-04-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
1FMK
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BU of 1fmk by Molmil
CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC
分子名称: TYROSINE-PROTEIN KINASE SRC
著者Xu, W, Harrison, S.C, Eck, M.J.
登録日1997-01-24
公開日1997-08-20
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Three-dimensional structure of the tyrosine kinase c-Src.
Nature, 385, 1997
1IJQ
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BU of 1ijq by Molmil
Crystal Structure of the LDL Receptor YWTD-EGF Domain Pair
分子名称: LOW-DENSITY LIPOPROTEIN RECEPTOR
著者Jeon, H, Meng, W, Takagi, J, Eck, M.J, Springer, T.A, Blacklow, S.C.
登録日2001-04-27
公開日2001-05-23
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
Nat.Struct.Biol., 8, 2001
1OX9
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BU of 1ox9 by Molmil
Crystal structure of SspB-ssrA complex
分子名称: Stringent starvation protein B, ssrA
著者Song, H.K, Eck, M.J.
登録日2003-04-01
公開日2003-08-26
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine
Mol.Cell, 12, 2003
7JXL
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BU of 7jxl by Molmil
EGFR kinase (T790M/V948R) in complex with AZ5104
分子名称: Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide
著者Beyett, T.S, Eck, M.J.
登録日2020-08-27
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7K1I
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BU of 7k1i by Molmil
EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063
分子名称: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
著者Beyett, T.S, Eck, M.J.
登録日2020-09-07
公開日2021-09-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.202 Å)
主引用文献Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
7JXI
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BU of 7jxi by Molmil
EGFR kinase (T790M/V948R) in complex with PF-06747775
分子名称: Epidermal growth factor receptor, N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide
著者Beyett, T.S, Eck, M.J.
登録日2020-08-27
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Nat Commun, 13, 2022
1I1Q
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BU of 1i1q by Molmil
STRUCTURE OF THE COOPERATIVE ALLOSTERIC ANTHRANILATE SYNTHASE FROM SALMONELLA TYPHIMURIUM
分子名称: ANTHRANILATE SYNTHASE COMPONENT I, ANTHRANILATE SYNTHASE COMPONENT II, TRYPTOPHAN
著者Morollo, A.A, Eck, M.J.
登録日2001-02-02
公開日2001-04-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the cooperative allosteric anthranilate synthase from Salmonella typhimurium.
Nat.Struct.Biol., 8, 2001
6Q0T
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BU of 6q0t by Molmil
Structure of a MAPK pathway complex
分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
著者Park, E, Rawson, S, Jeon, H, Eck, M.J.
登録日2019-08-02
公開日2019-10-09
最終更新日2020-04-22
実験手法ELECTRON MICROSCOPY (5.7 Å)
主引用文献Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
1NTV
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BU of 1ntv by Molmil
Crystal Structure of the Disabled-1 (Dab1) PTB domain-ApoER2 peptide complex
分子名称: Apolipoprotein E Receptor-2 peptide, Disabled homolog 1, PHOSPHATE ION
著者Stolt, P.C, Jeon, H, Song, H.K, Herz, J, Eck, M.J, Blacklow, S.C.
登録日2003-01-30
公開日2003-04-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes
Structure, 11, 2003
1OX8
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Crystal structure of SspB
分子名称: Stringent starvation protein B
著者Song, H.K, Eck, M.J.
登録日2003-04-01
公開日2003-08-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine
Mol.Cell, 12, 2003
1Q68
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Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments
分子名称: Proto-oncogene tyrosine-protein kinase LCK, T-cell surface glycoprotein CD4, ZINC ION
著者Kim, P.W, Sun, Z.Y, Blacklow, S.C, Wagner, G, Eck, M.J.
登録日2003-08-12
公開日2003-11-25
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
Science, 301, 2003
1P4Q
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Solution structure of the CITED2 transactivation domain in complex with the p300 CH1 domain
分子名称: Cbp/p300-interacting transactivator 2, E1A-associated protein p300, ZINC ION
著者Freedman, S.J, Sun, Z.-Y.J, Kung, A.L, France, D.S, Wagner, G, Eck, M.J.
登録日2003-04-23
公開日2003-07-01
最終更新日2017-02-01
実験手法SOLUTION NMR
主引用文献Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2.
Nat.Struct.Biol., 10, 2003
1Q69
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Solution structure of T-cell surface glycoprotein CD8 alpha chain and Proto-oncogene tyrosine-protein kinase LCK fragments
分子名称: Proto-oncogene tyrosine-protein kinase LCK, T-cell surface glycoprotein CD8 alpha chain, ZINC ION
著者Kim, P.W, Sun, Z.Y, Blacklow, S.C, Wagner, G, Eck, M.J.
登録日2003-08-12
公開日2003-11-25
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
Science, 301, 2003
3ZDT
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BU of 3zdt by Molmil
Crystal structure of basic patch mutant FAK FERM domain FAK31- 405 K216A, K218A, R221A, K222A
分子名称: FOCAL ADHESION KINASE 1
著者Goni, G.M, Epifano, C, Boskovic, J, Camacho-Artacho, M, Zhou, J, Martin, M.T, Eck, M.J, Kremer, L, Graeter, F, Gervasio, F.L, Perez-Moreno, M, Lietha, D.
登録日2012-11-30
公開日2012-12-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CYE
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BU of 4cye by Molmil
Crystal structure of avian FAK FERM domain FAK31-405 at 3.2A
分子名称: FOCAL ADHESION KINASE 1
著者Goni, G.M, Epifano, C, Boskovic, J, Camacho-Artacho, M, Zhou, J, Martin, M.T, Eck, M.J, Kremer, L, Graeter, F, Gervasio, F.L, Perez-Moreno, M, Lietha, D.
登録日2014-04-10
公開日2014-04-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes.
Proc.Natl.Acad.Sci.USA, 111, 2014

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