2R9N
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![BU of 2r9n by Molmil](/molmil-images/mine/2r9n) | Cathepsin S complexed with Compound 26 | Descriptor: | Cathepsin S, N-[(1S)-2-{[(3S)-1-benzyl-3-cyanopyrrolidin-3-yl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide | Authors: | Ward, Y.D, Emmanuel, M.J, Thomson, D.S, Liu, W, Bekkali, Y, Frye, L.L, Girardot, M, Morwick, T, Young, E.R.R, Zindell, R, Hrapchak, M, DeTuri, M, White, A, Crane, K.M, White, D.M, Wang, Y, Hao, M.-H, Grygon, C.A, Labadia, M.E, Wildeson, J, Freeman, D, Nelson, R, Capolino, A, Peterson, J.D, Raymond, E.L, Brown, M.L, Spero, D.M. | Deposit date: | 2007-09-13 | Release date: | 2007-12-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation to be published
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1EFR
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![BU of 1efr by Molmil](/molmil-images/mine/1efr) | BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH THE PEPTIDE ANTIBIOTIC EFRAPEPTIN | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BOVINE MITOCHONDRIAL F1-ATPASE SUBUNIT ALPHA, BOVINE MITOCHONDRIAL F1-ATPASE SUBUNIT BETA, ... | Authors: | Abrahams, J.P, Buchanan, S.K, Van Raaij, M.J, Fearnley, I.M, Leslie, A.G.W, Walker, J.E. | Deposit date: | 1996-05-24 | Release date: | 1997-02-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The Structure of Bovine F1-ATPase Complexed with the Peptide Antibiotic Efrapeptin. Proc.Natl.Acad.Sci.USA, 93, 1996
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3EBC
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![BU of 3ebc by Molmil](/molmil-images/mine/3ebc) | Structure of N141A HincII with Cognate DNA | Descriptor: | 5'-D(*DGP*DCP*DCP*DCP*DGP*DTP*DCP*DGP*DAP*DCP*DCP*DGP*DGP*DC)-3', 5'-D(*DGP*DCP*DCP*DGP*DGP*DTP*DCP*DGP*DAP*DCP*DGP*DGP*DGP*DC)-3', MANGANESE (II) ION, ... | Authors: | Little, E.J, Babic, A.C, Horton, N.C. | Deposit date: | 2008-08-27 | Release date: | 2008-12-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Early Interrogation and Recognition of DNA Sequence by Indirect Readout Structure, 16, 2008
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7A7H
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![BU of 7a7h by Molmil](/molmil-images/mine/7a7h) | Crystal structure of PPARgamma in complex with compound TK90 | Descriptor: | (2~{R})-2-[[4-[[4-methoxy-2-(trifluoromethyl)phenyl]methylcarbamoyl]phenyl]methyl]butanoic acid, 1,2-ETHANEDIOL, Peroxisome proliferator-activated receptor gamma | Authors: | Ni, X, Kirchner, T, Proschak, E, Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2020-08-28 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPAR gamma Modulator. J.Med.Chem., 64, 2021
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8C8F
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![BU of 8c8f by Molmil](/molmil-images/mine/8c8f) | |
6V7B
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![BU of 6v7b by Molmil](/molmil-images/mine/6v7b) | Cryo-EM reconstruction of Pyrobaculum filamentous virus 2 (PFV2) | Descriptor: | A-DNA, Structural protein VP1, Structural protein VP2 | Authors: | Wang, F, Baquero, D.P, Su, Z, Prangishvili, D, Krupovic, M, Egelman, E.H. | Deposit date: | 2019-12-08 | Release date: | 2020-04-01 | Last modified: | 2020-05-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of a filamentous virus uncovers familial ties within the archaeal virosphere. Virus Evol, 6, 2020
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7EKB
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![BU of 7ekb by Molmil](/molmil-images/mine/7ekb) | Crystal structure of 4E10 modified with pyrene acetamide | Descriptor: | ACETATE ION, Fab region of the heavy chain of broadly neutralizing antibody anti-HIV-1 4E10, Fab region of the light chain of the broadly neutralizing anti-HIV-1 antibody 4E10, ... | Authors: | Caaveiro, J.M.M, Rujas, E, Nieva, J.L. | Deposit date: | 2021-04-05 | Release date: | 2021-08-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile. Iscience, 24, 2021
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1IEM
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![BU of 1iem by Molmil](/molmil-images/mine/1iem) | Crystal Structure of AmpC beta-lactamase from E. coli in Complex with a Boronic Acid Inhibitor (1, CefB4) | Descriptor: | PHOSPHATE ION, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, beta-lactamase | Authors: | Powers, R.A, Caselli, E, Focia, P.J, Prati, F, Shoichet, B.K. | Deposit date: | 2001-04-10 | Release date: | 2001-08-15 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design. Biochemistry, 40, 2001
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1J6V
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![BU of 1j6v by Molmil](/molmil-images/mine/1j6v) | CRYSTAL STRUCTURE OF D. RADIODURANS LUXS, C2 | Descriptor: | AUTOINDUCER-2 PRODUCTION PROTEIN LUXS, ZINC ION | Authors: | Lewis, H.A, Furlong, E.B, Bergseid, M.G, Sanderson, W.E, Buchanan, S.G. | Deposit date: | 2001-05-14 | Release date: | 2001-06-08 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs. Structure, 9, 2001
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2IZS
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![BU of 2izs by Molmil](/molmil-images/mine/2izs) | Structure of casein kinase gamma 3 in complex with inhibitor | Descriptor: | CASEIN KINASE I ISOFORM GAMMA-3, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Bunkoczi, G, Salah, E, Rellos, P, Das, S, Fedorov, O, Savitsky, P, Debreczeni, J.E, Gileadi, O, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, von Delft, F, Knapp, S. | Deposit date: | 2006-07-26 | Release date: | 2006-08-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Inhibitor Binding by Casein Kinases To be Published
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7EKK
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![BU of 7ekk by Molmil](/molmil-images/mine/7ekk) | Anti-HIV-1 broadly neutralizing antibody delta-loop 4E10 modified with pyrene acetamide | Descriptor: | AMMONIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Caaveiro, J.M.M, Rujas, E, Nieva, J.L. | Deposit date: | 2021-04-05 | Release date: | 2021-08-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile. Iscience, 24, 2021
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8CPX
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![BU of 8cpx by Molmil](/molmil-images/mine/8cpx) | Human apoferritin after 488 nm laser exposure in presence of rsEGFP2 | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.76 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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8CPM
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![BU of 8cpm by Molmil](/molmil-images/mine/8cpm) | Human apoferritin after 405 nm laser exposure | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.81 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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8CPU
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![BU of 8cpu by Molmil](/molmil-images/mine/8cpu) | Human apoferritin after 561 nm laser exposure | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.76 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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1IEL
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![BU of 1iel by Molmil](/molmil-images/mine/1iel) | Crystal Structure of AmpC beta-lactamase from E. coli in Complex with Ceftazidime | Descriptor: | ACYLATED CEFTAZIDIME, PHOSPHATE ION, beta-lactamase | Authors: | Powers, R.A, Caselli, E, Focia, P.J, Prati, F, Shoichet, B.K. | Deposit date: | 2001-04-10 | Release date: | 2001-08-15 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design. Biochemistry, 40, 2001
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8CPT
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![BU of 8cpt by Molmil](/molmil-images/mine/8cpt) | Human apoferritin after 488 nm laser exposure | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.79 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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6VH7
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![BU of 6vh7 by Molmil](/molmil-images/mine/6vh7) | Doublet Tau Fibril from Corticobasal Degeneration Human Brain Tissue | Descriptor: | Microtubule-associated protein tau | Authors: | Arakhamia, T, Lee, C.E, Carlomagno, Y, Duong, D.M, Kundinger, S.R, Wang, K, Williams, D, DeTure, M, Dickson, D.W, Cook, C.N, Seyfried, N.T, Petrucelli, L, Fitzpatrick, A.W.P. | Deposit date: | 2020-01-09 | Release date: | 2020-03-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. Cell, 180, 2020
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8CPV
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![BU of 8cpv by Molmil](/molmil-images/mine/8cpv) | Human apoferritin | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.76 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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2GHL
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![BU of 2ghl by Molmil](/molmil-images/mine/2ghl) | Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743 | Descriptor: | 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA, Mitogen-activated protein kinase 14 | Authors: | Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Brugel, T.A. | Deposit date: | 2006-03-27 | Release date: | 2006-04-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1. Bioorg.Med.Chem.Lett., 16, 2006
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6IOK
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![BU of 6iok by Molmil](/molmil-images/mine/6iok) | Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) | Descriptor: | Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM | Authors: | Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E. | Deposit date: | 2018-10-30 | Release date: | 2019-04-03 | Last modified: | 2019-04-17 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism. Nat Commun, 10, 2019
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3E3Y
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![BU of 3e3y by Molmil](/molmil-images/mine/3e3y) | Q138F HincII bound to GTTAAC and cocrystallized with 5 mM Ca2+ | Descriptor: | 5'-D(*DGP*DCP*DCP*DGP*DGP*DTP*DTP*DAP*DAP*DCP*DCP*DGP*DGP*DC)-3', CALCIUM ION, SODIUM ION, ... | Authors: | Horton, N.C, Babic, A.C, Little, E.J, Manohar, V.M. | Deposit date: | 2008-08-08 | Release date: | 2008-08-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | DNA distortion and specificity in a sequence-specific endonuclease. J.Mol.Biol., 383, 2008
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8CPS
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![BU of 8cps by Molmil](/molmil-images/mine/8cps) | Human apoferritin | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.82 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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1A1I
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![BU of 1a1i by Molmil](/molmil-images/mine/1a1i) | RADR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GCAC SITE) | Descriptor: | DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*CP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*GP*CP*CP*CP*AP*CP*GP*C)-3'), RADR ZIF268 ZINC FINGER PEPTIDE, ... | Authors: | Elrod-Erickson, M, Benson, T.E, Pabo, C.O. | Deposit date: | 1997-12-10 | Release date: | 1998-06-17 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition. Structure, 6, 1998
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8CPW
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![BU of 8cpw by Molmil](/molmil-images/mine/8cpw) | Human apoferritin after 405 nm + 488 nm laser exposure in presence of rsEGFP2 | Descriptor: | Ferritin heavy chain, N-terminally processed, MAGNESIUM ION, ... | Authors: | Last, M.G.F, Noteborn, W.E.M, Sharp, T.H. | Deposit date: | 2023-03-03 | Release date: | 2023-03-15 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (1.79 Å) | Cite: | Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM. J.Struct.Biol., 215, 2023
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1WW2
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![BU of 1ww2 by Molmil](/molmil-images/mine/1ww2) | Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase | Descriptor: | Glycogen phosphorylase, muscle form, N-acetyl-beta-D-glucopyranosylamine, ... | Authors: | Anagnostou, E, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Hadjiloi, T, Tiraidis, C, Zographos, S.E, Gyorgydeak, Z, Somsak, L, Docsa, T, Gergely, P, Kolisis, F.N, Oikonomakos, N.G. | Deposit date: | 2004-12-30 | Release date: | 2005-12-13 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-d-glucopyranosylamine and N-trifluoroacetyl-beta-d-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Bioorg.Med.Chem., 14, 2006
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