2R9N
Cathepsin S complexed with Compound 26
Summary for 2R9N
Entry DOI | 10.2210/pdb2r9n/pdb |
Related | 2R9M 2R9O |
Descriptor | Cathepsin S, N-[(1S)-2-{[(3S)-1-benzyl-3-cyanopyrrolidin-3-yl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide (3 entities in total) |
Functional Keywords | hydrolase, cathepsin, protease, glycoprotein, lysosome, polymorphism, thiol protease, zymogen |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 50330.55 |
Authors | Ward, Y.D.,Emmanuel, M.J.,Thomson, D.S.,Liu, W.,Bekkali, Y.,Frye, L.L.,Girardot, M.,Morwick, T.,Young, E.R.R.,Zindell, R.,Hrapchak, M.,DeTuri, M.,White, A.,Crane, K.M.,White, D.M.,Wang, Y.,Hao, M.-H.,Grygon, C.A.,Labadia, M.E.,Wildeson, J.,Freeman, D.,Nelson, R.,Capolino, A.,Peterson, J.D.,Raymond, E.L.,Brown, M.L.,Spero, D.M. (deposition date: 2007-09-13, release date: 2007-12-18, Last modification date: 2023-08-30) |
Primary citation | Ward, Y.D.,Emmanuel, M.J.,Thomson, D.S.,Liu, W.,Bekkali, Y.,Frye, L.L.,Girardot, M.,Morwick, T.,Young, E.R.R.,Zindell, R.,Hrapchak, M.,DeTuri, M.,White, A.,Crane, K.M.,White, D.M.,Wang, Y.,Hao, M.-H.,Grygon, C.A.,Labadia, M.E.,Wildeson, J.,Freeman, D.,Nelson, R.,Capolino, A.,Peterson, J.D.,Raymond, E.L.,Brown, M.L.,Spero, D.M. Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation to be published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report