3U8N
| Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3950 (1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane) | 分子名称: | 1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine-binding protein, ... | 著者 | Rohde, L.A.H, Ahring, P.K, Jensen, M.L, Nielsen, E.O, Peters, D, Helgstrand, C, Krintel, C, Harpsoe, K, Gajhede, M, Kastrup, J.S, Balle, T. | 登録日 | 2011-10-17 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed. J.Biol.Chem., 287, 2012
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7QYS
| Crystal structure of RimK from Pseudomonas syringae DC3000 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Probable alpha-L-glutamate ligase | 著者 | Thompson, C.M.A, Little, R.H, Stevenson, C.E.M, Lawson, D.M, Malone, J.G. | 登録日 | 2022-01-29 | 公開日 | 2022-10-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural insights into the mechanism of adaptive ribosomal modification by Pseudomonas RimK. Proteins, 91, 2023
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5MDI
| Crystal structure of TDP-43 N-terminal domain at 2.1 A resolution | 分子名称: | ACETATE ION, TAR DNA-binding protein 43 | 著者 | Afroz, T, Hock, E.-M, Ernst, P, Foglieni, C, Jambeau, M, Gilhespy, L, Laferriere, F, Maniecka, Z, Plueckthun, A, Mittl, P, Paganetti, P, Allain, F.H.T, Polymenidou, M. | 登録日 | 2016-11-11 | 公開日 | 2017-07-05 | 最終更新日 | 2017-07-12 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation. Nat Commun, 8, 2017
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5F8Q
| Blood group antigen binding adhesin BabA of Helicobacter pylori strain S831 in complex with Nanobody Nb-ER19 | 分子名称: | Adhesin binding fucosylated histo-blood group antigen,Adhesin,Adhesin binding fucosylated histo-blood group antigen, Nanobody Nb-ER19 | 著者 | Moonens, K, Gideonsson, P, Subedi, S, Romao, E, Oscarson, S, Muyldermans, S, Boren, T, Remaut, H. | 登録日 | 2015-12-09 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori. Cell Host Microbe, 19, 2016
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5F9D
| Blood group antigen binding adhesin BabA of Helicobacter pylori strain P436 in complex with Lewis b blood group B heptasaccharide | 分子名称: | Adhesin binding fucosylated histo-blood group antigen,Adhesin,Adhesin binding fucosylated histo-blood group antigen, Nanobody Nb-ER19, alpha-L-fucopyranose-(1-2)-[alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-3)-[alpha-L-fucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | 著者 | Moonens, K, Gideonsson, P, Subedi, S, Romao, E, Oscarson, S, Muyldermans, S, Boren, T, Remaut, H. | 登録日 | 2015-12-09 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori. Cell Host Microbe, 19, 2016
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6ELI
| Structure of HIV-1 reverse transcriptase (RT) in complex with rilpivirine and an RNase H inhibitor XZ462 | 分子名称: | 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, Gag-Pol polyprotein, ... | 著者 | Das, K, Arnold, E. | 登録日 | 2017-09-29 | 公開日 | 2018-04-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase. J. Virol., 92, 2018
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8QKF
| SmtB protein of Mycobacterium smegmatis | 分子名称: | ArsR family transcriptional regulator | 著者 | Potocki, S, Pyra, A, Nowak, E, Rola, A, Plaskowka, K, Trojanowski, D, Holowka, J, Pasikowski, P, Gumienna-Kontecka, E, Zakrzewska-Czerwinska, J. | 登録日 | 2023-09-15 | 公開日 | 2024-09-25 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | SmtB protein of Mycobacterium smegmatis To Be Published
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5MRD
| Human PDK1-PKCiota Kinase Chimera in Complex with Allosteric Compound PS267 Bound to the PIF-Pocket | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Arencibia, J.M, Froehner, W, Krupa, M, Pastor-Flores, D, Merker, P, Oellerich, T, Neimanis, S, Schmithals, C, Koeberle, V, Suess, E, Zeuzem, S, Stark, H, Piiper, A, Odadzic, D, Schulze, J.O, Biondi, R.M. | 登録日 | 2016-12-22 | 公開日 | 2017-01-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. ACS Chem. Biol., 12, 2017
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3LEE
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1RRE
| Crystal structure of E.coli Lon proteolytic domain | 分子名称: | ATP-dependent protease La, SULFATE ION | 著者 | Botos, I, Melnikov, E.E, Cherry, S, Tropea, J.E, Khalatova, A.G, Rasulova, F, Dauter, Z, Maurizi, M.R, Rotanova, T.V, Wlodawer, A, Gustchina, A. | 登録日 | 2003-12-08 | 公開日 | 2004-02-03 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site J.Biol.Chem., 279, 2004
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5MSB
| Crystal structure of human carbonic anhydrase isozyme XII with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide | 分子名称: | 1,2-ETHANEDIOL, 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, Carbonic anhydrase 12, ... | 著者 | Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2017-01-02 | 公開日 | 2018-01-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding. PeerJ, 6, 2018
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5FH6
| Crystal structure of the fifth bromodomain of human PB1 in complex with compound 10 | 分子名称: | (3~{R})-3-(piperidin-1-ylmethyl)-2,3-dihydro-1~{H}-pyrrolo[1,2-a]quinazolin-5-one, Protein polybromo-1 | 著者 | Tallant, C, Sutherell, C.L, Siejka, P, Krojer, T, Picaud, S, Fonseca, M, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Brennan, P.E, Ley, S.V, Knapp, S. | 登録日 | 2015-12-21 | 公開日 | 2016-06-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex. J.Med.Chem., 59, 2016
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5UBO
| Mical-oxidized Actin complex with Gelsolin Segment 1 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | 著者 | Grintsevich, E.E, Sawaya, M.R, Reisler, E. | 登録日 | 2016-12-21 | 公開日 | 2017-12-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Catastrophic disassembly of actin filaments via Mical-mediated oxidation. Nat Commun, 8, 2017
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3E3Y
| Q138F HincII bound to GTTAAC and cocrystallized with 5 mM Ca2+ | 分子名称: | 5'-D(*DGP*DCP*DCP*DGP*DGP*DTP*DTP*DAP*DAP*DCP*DCP*DGP*DGP*DC)-3', CALCIUM ION, SODIUM ION, ... | 著者 | Horton, N.C, Babic, A.C, Little, E.J, Manohar, V.M. | 登録日 | 2008-08-08 | 公開日 | 2008-08-26 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | DNA distortion and specificity in a sequence-specific endonuclease. J.Mol.Biol., 383, 2008
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1B0L
| RECOMBINANT HUMAN DIFERRIC LACTOFERRIN | 分子名称: | CARBONATE ION, FE (III) ION, PROTEIN (LACTOFERRIN) | 著者 | Baker, E.N, Jameson, G.B, Sun, X. | 登録日 | 1998-11-11 | 公開日 | 1999-11-18 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of recombinant human lactoferrin expressed in Aspergillus awamori. Acta Crystallogr.,Sect.D, 55, 1999
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2FU2
| Crystal structure of protein SPy2152 from Streptococcus pyogenes | 分子名称: | Hypothetical protein SPy2152 | 著者 | Chang, C, Cymborowski, M, Otwinowski, Z, Minor, W, Lezondra, L.-E, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2006-01-25 | 公開日 | 2006-03-07 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The structure of pyogenecin immunity protein, a novel bacteriocin-like immunity protein from Streptococcus pyogenes. Bmc Struct.Biol., 9, 2009
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3EBC
| Structure of N141A HincII with Cognate DNA | 分子名称: | 5'-D(*DGP*DCP*DCP*DCP*DGP*DTP*DCP*DGP*DAP*DCP*DCP*DGP*DGP*DC)-3', 5'-D(*DGP*DCP*DCP*DGP*DGP*DTP*DCP*DGP*DAP*DCP*DGP*DGP*DGP*DC)-3', MANGANESE (II) ION, ... | 著者 | Little, E.J, Babic, A.C, Horton, N.C. | 登録日 | 2008-08-27 | 公開日 | 2008-12-23 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Early Interrogation and Recognition of DNA Sequence by Indirect Readout Structure, 16, 2008
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6S0F
| Crystal structure of an inverting family GH156 exosialidase from uncultured bacterium pG7 in complex with 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GLYCEROL, ... | 著者 | Bule, P, Blagova, E, Chuzel, L, Taron, C.H, Davies, G.J. | 登録日 | 2019-06-14 | 公開日 | 2019-11-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action. Nat Commun, 10, 2019
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5BSI
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6ARK
| Crystal Structure of compound 10 covalently bound to K-Ras G12C | 分子名称: | (3R)-N-(6-bromonaphthalen-2-yl)-3-hydroxy-1-propanoyl-L-prolinamide, GLYCEROL, GTPase KRas, ... | 著者 | Nnadi, C.I, Jenkins, M.L, Gentile, D.R, Bateman, L.A, Zaidman, D, Balius, T.E, Nomura, D.K, Burke, J.E, Shokat, K.M, London, N. | 登録日 | 2017-08-22 | 公開日 | 2018-01-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange. J Chem Inf Model, 58, 2018
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6EHJ
| Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and peptide bound | 分子名称: | ASPARAGINE, COENZYME A, GLYCEROL, ... | 著者 | Perez-Dorado, I, Ritzefeld, M, Tate, E.W. | 登録日 | 2017-09-13 | 公開日 | 2019-03-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
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6S1Y
| Crystal structure of Anopheles gambiae AnoACE2 in complex with gamma-Polyglutamic Acid. | 分子名称: | (2~{S})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Cozier, G.E, Acharya, K.R, Cashman, J.S. | 登録日 | 2019-06-19 | 公開日 | 2019-11-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of angiotensin-converting enzyme from Anopheles gambiae in its native form and with a bound inhibitor. Biochem.J., 476, 2019
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4XQW
| X-ray structure analysis of xylanase-N44E with MES at pH6.0 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Endo-1,4-beta-xylanase 2, IODIDE ION | 著者 | Wan, Q, Park, J.M, Riccardi, D.M, Hanson, L.B, Fisher, Z, Smith, J.C, Ostermann, A, Schrader, T, Graham, D.E, Coates, L, Langan, P, Kovalevsky, A.Y. | 登録日 | 2015-01-20 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Direct determination of protonation states and visualization of hydrogen bonding in a glycoside hydrolase with neutron crystallography. Proc.Natl.Acad.Sci.USA, 112, 2015
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7RFQ
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6PLR
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with glycine in nanodisc, desensitized state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor subunit alphaZ1, ... | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-01-06 | 最終更新日 | 2021-07-21 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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