3LEE

Crystal structure of the human squalene synthase complexed with BPH-652

Summary for 3LEE

• Entry DOI: 10.2210/pdb3lee/pdb
• Descriptor: Squalene synthetase, (1R)-4-(3-phenoxyphenyl)-1-phosphonobutane-1-sulfonic acid, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: transferase, isoprenoid synthase fold, cholesterol biosynthesis, endoplasmic reticulum, isoprene biosynthesis, lipid synthesis, magnesium, membrane, multifunctional enzyme, nadp, oxidoreductase, steroid biosynthesis, sterol biosynthesis, transmembrane
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268
• Total number of polymer chains: 6
• Total formula weight: 237464.17

Authors

Liu, Y.-L.,Lin, F.-Y.,Oldfield, E. (deposition date: 2010-01-14, release date: 2010-12-08, Last modification date: 2024-02-21)

• Primary citation: Lin, F.-Y.,Liu, C.-I.,Liu, Y.-L.,Zhang, Y.,Wang, K.,Cao, R.,Wang, A.H.J.,Oldfield, E.; Mechanism of Action (and Inhibition) of Head-to-Head Terpene Synthases: A Structural Investigation; To be Published,

Experimental method

X-RAY DIFFRACTION (3.2 Å)