6ELI

Structure of HIV-1 reverse transcriptase (RT) in complex with rilpivirine and an RNase H inhibitor XZ462

Summary for 6ELI

Entry DOI	10.2210/pdb6eli/pdb
Related	4G1Q
Descriptor	reverse transcriptase, Gag-Pol polyprotein, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (8 entities in total)
Functional Keywords	p51/p66, hetero dimer, nnrti, ribonuclease h inhibitor, nonnucleoside inhibitor, aids, hiv, r278474, diarylpyrimidine, dapy, dna recombination, dna polymerase, endonuclease, hydrolase, multifunctional, enzyme, transferase, hydrolase-inhibitor complex
Biological source	Human immunodeficiency virus type 1 BH10 More
Total number of polymer chains	2
Total formula weight	115049.35
Authors	Das, K.,Arnold, E. (deposition date: 2017-09-29, release date: 2018-04-11, Last modification date: 2024-01-17)
Primary citation	Boyer, P.L.,Smith, S.J.,Zhao, X.Z.,Das, K.,Gruber, K.,Arnold, E.,Burke, T.R.,Hughes, S.H. Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase. J. Virol., 92:-, 2018 Cited by PubMed: 29643235 DOI: 10.1128/JVI.02203-17 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation