3T6P
 
 | | IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization | | Descriptor: | Baculoviral IAP repeat-containing protein 2, ZINC ION | | Authors: | Dueber, E.C, Schoeffler, A.J, Lingel, A, Elliott, M, Fedorova, A.V, Giannetti, A.M, Zobel, K, Maurer, B, Varfolomeev, E, Wu, P, Wallweber, H, Hymowitz, S, Deshayes, K, Vucic, D, Fairbrother, W.J. | | Deposit date: | 2011-07-28 | | Release date: | 2011-11-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.897 Å) | | Cite: | Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Science, 334, 2011
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7UJD
 | | PSMD2 Structure bound to MC1 and Fab8/14 | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 2, ACY-PHE-PRO-ASP-VAL-SAR-LEU-HIS-ARG-TYR-TRP-GLY-TRP-ASP-CYS-GLY-NH2, Fab 14 HC CDRs, ... | | Authors: | Johnson, M.C, Bashore, C, Ciferri, C, Dueber, E.C. | | Deposit date: | 2022-03-30 | | Release date: | 2023-01-11 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Targeted degradation via direct 26S proteasome recruitment.
Nat.Chem.Biol., 19, 2023
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7UIH
 | | PSMD2 Structure | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 2, Fab 14 HC CDRs, Fab 14 LC CDRs, ... | | Authors: | Johnson, M.C, Bashore, C, Ciferri, C, Dueber, E.C. | | Deposit date: | 2022-03-29 | | Release date: | 2023-01-11 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Targeted degradation via direct 26S proteasome recruitment.
Nat.Chem.Biol., 19, 2023
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6N2P
 | | Helical assembly of the CARD9 CARD | | Descriptor: | Caspase recruitment domain-containing protein 9 | | Authors: | Holliday, M.J, Rohou, A, Arthur, C.P, Dueber, E.C, Fairbrother, W.J. | | Deposit date: | 2018-11-13 | | Release date: | 2019-07-03 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Nat Commun, 10, 2019
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6N2M
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4EUU
 | | Structure of BX-795 Complexed with Human TBK1 Kinase Domain Phosphorylated on Ser172 | | Descriptor: | GLYCEROL, IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, ... | | Authors: | Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C. | | Deposit date: | 2012-04-25 | | Release date: | 2012-05-23 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4EUT
 | | Structure of BX-795 Complexed with Unphosphorylated Human TBK1 Kinase-ULD Domain | | Descriptor: | IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, SULFATE ION, ... | | Authors: | Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C. | | Deposit date: | 2012-04-25 | | Release date: | 2012-05-23 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
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6E26
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6E25
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9DEN
 | | USP7 in complex with macrocycle MC07 | | Descriptor: | ETHANOL, Macrocycle peptide MC07, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Ultsch, M, Tenorio, C.A, Dueber, E.C, Harris, S.F. | | Deposit date: | 2024-08-29 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7.
Structure, 33, 2025
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9DEP
 | | USP7 in complex with macrocycle MC09 | | Descriptor: | Macrocycle peptide MC09, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Ultsch, M, Tenorio, C.A, Dueber, E.C, Harris, S.F. | | Deposit date: | 2024-08-29 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7.
Structure, 33, 2025
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9DEL
 | | USP7 in complex with macrocycle MC03 | | Descriptor: | Macrocycle peptide MC03, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Ultsch, M, Tenorio, C.A, Dueber, E.C, Harris, S.F. | | Deposit date: | 2024-08-29 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7.
Structure, 33, 2025
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9DEK
 | | USP7 in complex with macrocycle inhibitor MC02 | | Descriptor: | GLYCEROL, Macrocycle peptide MC02, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Rouge, L, Ultsch, M, Holden, J.K, Dueber, E.C, Harris, S.F. | | Deposit date: | 2024-08-29 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7.
Structure, 33, 2025
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9DEO
 | | USP7 in complex with macrocycle inhibitor MC08 | | Descriptor: | Macrocycle peptide MC08, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Ultsch, M, Tenorio, C.A, Dueber, E.C, Harris, S.F. | | Deposit date: | 2024-08-29 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7.
Structure, 33, 2025
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9DEM
 | | USP7 in complex with macrocycle MC04 | | Descriptor: | Macrocycle peptide MC04, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Rouge, L, Ultsch, M, Dueber, E.C, Harris, S.F. | | Deposit date: | 2024-08-29 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7.
Structure, 33, 2025
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