1UR6
 
 | | NMR based structural model of the UbcH5B-CNOT4 complex | | Descriptor: | POTENTIAL TRANSCRIPTIONAL REPRESSOR NOT4HP, UBIQUITIN-CONJUGATING ENZYME E2-17 KDA 2, ZINC ION | | Authors: | Dominguez, C, Bonvin, A.M.J.J, Winkler, G.S, Van Schaik, F.M.A, Timmers, H.Th.M, Boelens, R. | | Deposit date: | 2003-10-27 | | Release date: | 2004-05-07 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR, THEORETICAL MODEL | | Cite: | Structural Model of the Ubch5B/Cnot4 Complex Revealed by Combining NMR, Mutagenesis, and Docking Approaches.
Structure, 12, 2004
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2HGL
 | | NMR structure of the first qRRM domain of human hnRNP F | | Descriptor: | Heterogeneous nuclear ribonucleoprotein F | | Authors: | Dominguez, C, Allain, F.H.-T. | | Deposit date: | 2006-06-27 | | Release date: | 2006-07-11 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.
Nucleic Acids Res., 34, 2006
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2HGN
 | | NMR structure of the third qRRM domain of human hnRNP F | | Descriptor: | Heterogeneous nuclear ribonucleoprotein F | | Authors: | Dominguez, C, Allain, F.H.-T. | | Deposit date: | 2006-06-27 | | Release date: | 2006-07-11 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.
Nucleic Acids Res., 34, 2006
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2HGM
 | | NMR structure of the second qRRM domain of human hnRNP F | | Descriptor: | Heterogeneous nuclear ribonucleoprotein F | | Authors: | Dominguez, C, Allain, F.H.-T. | | Deposit date: | 2006-06-27 | | Release date: | 2006-07-11 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.
Nucleic Acids Res., 34, 2006
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5ELR
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5EL3
 | | Structure of the KH domain of T-STAR | | Descriptor: | KH domain-containing, RNA-binding, signal transduction-associated protein 3, ... | | Authors: | Dominguez, C, Feracci, M. | | Deposit date: | 2015-11-04 | | Release date: | 2016-01-13 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Nat Commun, 7, 2016
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5ELT
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5EMO
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5ELS
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1W4U
 | | NMR solution structure of the ubiquitin conjugating enzyme UbcH5B | | Descriptor: | UBIQUITIN-CONJUGATING ENZYME E2-17 KDA 2 | | Authors: | Houben, K, Dominguez, C, Van Schaik, F.M.A, Timmers, H.T.M, Bonvin, A.M.J.J, Boelens, R. | | Deposit date: | 2004-07-29 | | Release date: | 2004-11-10 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of the Ubiquitin-Conjugating Enzyme Ubch5B
J.Mol.Biol., 344, 2004
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8AU4
 | | Structural insights reveal a heterotetramer between oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator | | Descriptor: | Ral guanine nucleotide dissociation stimulator-like 2 | | Authors: | Tariq, M, Ikeya, T, Togashi, N, Fairall, L, Alejo, C.B, Kamei, S, Alonso, B.R, Campillo, M.A.M, Hudson, A, Ito, Y, Schwabe, J, Dominguez, C, Tanaka, K. | | Deposit date: | 2022-08-25 | | Release date: | 2023-08-23 | | Last modified: | 2023-10-25 | | Method: | SOLUTION NMR | | Cite: | Structural insights into the complex of oncogenic KRas4B G12V and Rgl2, a RalA/B activator.
Life Sci Alliance, 7, 2024
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8B69
 | | Heterotetramer of K-Ras4B(G12V) and Rgl2(RBD) | | Descriptor: | Isoform 2B of GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Tariq, M, Fairall, L, Romartinez-Alonso, B, Dominguez, C, Schwabe, J.W.R, Tanaka, K. | | Deposit date: | 2022-09-26 | | Release date: | 2023-08-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.07 Å) | | Cite: | Structural insights into the complex of oncogenic KRas4B G12V and Rgl2, a RalA/B activator.
Life Sci Alliance, 7, 2024
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8R2O
 | | Huntingtin-Q17, 1-66, N-MBP fusion | | Descriptor: | Maltodextrin-binding protein,Huntingtin, myristoylated N-terminal fragment, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Toledo-Sherman, L, Dominguez, C. | | Deposit date: | 2023-11-07 | | Release date: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (3.23 Å) | | Cite: | Post-translational modifications in the first 17 amino acids of huntingtin influence self-association and interaction with membranes
To Be Published
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4CBT
 | | Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease | | Descriptor: | (1R,2R,3R)-2-[4-(5-fluoranylpyrimidin-2-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide, HISTONE DEACETYLASE 4, ZINC ION | | Authors: | Burli, R.W, Luckhurst, C.A, Aziz, O, Matthews, K.L, Yates, D, Lyons, K.A, Beconi, M, McAllister, G, Breccia, P, Stott, A.J, Penrose, S.D, Wall, M, Lamers, M, Leonard, P, Mueller, I, Richardson, C.M, Jarvis, R, Stones, L, Hughes, S, Wishart, G, Haughan, A.F, O'Connell, C, Mead, T, McNeil, H, Vann, J, Mangette, J, Maillard, M, Beaumont, V, Munoz-Sanjuan, I, Dominguez, C. | | Deposit date: | 2013-10-16 | | Release date: | 2013-12-11 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.03 Å) | | Cite: | Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
J. Med. Chem., 56, 2013
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4CBY
 | | Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease | | Descriptor: | (1R,2R,3R)-2-[4-(1,3-oxazol-5-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide, HISTONE DEACETYLASE 4, SODIUM ION, ... | | Authors: | Burli, R.W, Luckhurst, C.A, Aziz, O, Matthews, K.L, Yates, D, Lyons, K.A, Beconi, M, McAllister, G, Breccia, P, Stott, A.J, Penrose, S.D, Wall, M, Lamers, M, Leonard, P, Mueller, I, Richardson, C.M, Jarvis, R, Stones, L, Hughes, S, Wishart, G, Haughan, A.F, O'Connell, C, Mead, T, McNeil, H, Vann, J, Mangette, J, Maillard, M, Beaumont, V, Munoz-Sanjuan, I, Dominguez, C. | | Deposit date: | 2013-10-17 | | Release date: | 2013-12-11 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
J. Med. Chem., 56, 2013
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6SP1
 | | KEAP1 IN COMPLEX WITH COMPOUND 6 | | Descriptor: | (1~{S},2~{R})-2-[[(1~{S})-1-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]-5-(2-hydroxyethyloxy)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]cyclohexane-1-carboxylic acid, ACETATE ION, Kelch-like ECH-associated protein 1 | | Authors: | Ontoria, J.M, Biancofiore, I, Fezzardi, P, Torrente de Haro, E, Colarusso, S, Bianchi, E, Andreini, M, Patsilinakos, A, Summa, V, Pacifici, R, Munoz-Sanjuan, I, Park, L, Bresciani, A, Dominguez, C, Toledo-Sherman, L, Harper, S. | | Deposit date: | 2019-08-30 | | Release date: | 2020-06-03 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction.
Acs Med.Chem.Lett., 11, 2020
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1YQJ
 | | Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor | | Descriptor: | 6((S)-3-BENZYLPIPERAZIN-1-YL)-3-(NAPHTHALEN-2-YL)-4-(PYRIDIN-4-YL)PYRAZINE, Mitogen-activated protein kinase 14, SULFATE ION | | Authors: | Tamayo, N, Liao, H, Goldberg, M, Syed, R, Li, V, Powers, D, Tudor, Y, Yu, V, Wong, M.L, Henkle, B, Middelton, S, Harvey, T, Jang, G, Hungate, R, Dominguez, C. | | Deposit date: | 2005-02-01 | | Release date: | 2005-04-26 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.
Bioorg.Med.Chem.Lett., 15, 2005
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6SP4
 | | KEAP1 IN COMPLEX WITH COMPOUND 23 | | Descriptor: | (1~{S},2~{R})-2-[[(1~{S})-1-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]-5-(2-hydroxyethyloxy)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]cyclobutane-1-carboxamide, Kelch-like ECH-associated protein 1 | | Authors: | Ontoria, J.M, Biancofiore, I, Fezzardi, P, Torrente de Haro, E, Colarusso, S, Bianchi, E, Andreini, M, Patsilinakos, A, Summa, V, Pacifici, R, Munoz-Sanjuan, I, Park, L, Bresciani, A, Dominguez, C, Toledo-Sherman, L, Harper, S. | | Deposit date: | 2019-08-30 | | Release date: | 2020-06-03 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction.
Acs Med.Chem.Lett., 11, 2020
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6FYZ
 | | Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor | | Descriptor: | (2~{S})-2-(2-fluorophenyl)-2-[4-(2-methylpyrimidin-5-yl)phenyl]-~{N}-oxidanyl-ethanamide, Histone deacetylase 4, SODIUM ION, ... | | Authors: | Luckhurst, C.A, Maillard, M.C, Dominguez, C. | | Deposit date: | 2018-03-13 | | Release date: | 2018-12-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.
Bioorg. Med. Chem. Lett., 29, 2019
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1Z60
 | | Solution structure of the carboxy-terminal domain of human TFIIH P44 subunit | | Descriptor: | TFIIH basal transcription factor complex p44 subunit, ZINC ION | | Authors: | Kellenberger, E, Dominguez, C, Fribourg, S, Wasielewski, E, Moras, D, Poterszman, A, Boelens, R, Kieffer, B. | | Deposit date: | 2005-03-21 | | Release date: | 2005-04-12 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the C-terminal domain of TFIIH P44 subunit reveals a novel type of C4C4 ring domain involved in protein-protein interactions.
J.Biol.Chem., 280, 2005
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2KG1
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2KFY
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3QNW
 | | Caspase-6 in complex with Z-VAD-FMK inhibitor | | Descriptor: | Caspase-6, Z-VAD-FMK | | Authors: | Mueller, I, Lamers, M, Ritchie, A, Park, H, Dominguez, C, Munoz, I, Maillard, M, Kiselyov, A. | | Deposit date: | 2011-02-09 | | Release date: | 2011-09-21 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation.
Bioorg.Med.Chem.Lett., 21, 2011
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2KG0
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8R3E
 | | Huntingtin, 1-17, MBP-N | | Descriptor: | Maltodextrin-binding protein, ZINC ION | | Authors: | Steinbacher, S, Toledo-Sherman, L, Dominguez, C. | | Deposit date: | 2023-11-08 | | Release date: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | Post-translational modifications in the first 17 amino acids of huntingtin influence self-association and interaction with membranes
To Be Published
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