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PDB: 215 件
8TLO
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BU of 8tlo by Molmil
Crystal Structure Analysis of BCL11A in complex with DNA
分子名称: B-cell lymphoma/leukemia 11A, DNA (5'-D(P*CP*GP*AP*CP*CP*GP*CP*AP*TP*TP*GP*GP*TP*CP*AP*AP*GP*CP*G)-3'), DNA (5'-D(P*GP*CP*TP*TP*GP*AP*CP*CP*AP*AP*TP*GP*CP*GP*GP*TP*CP*GP*C)-3'), ...
著者Seo, H.-S, Dhe-Paganon, S.
登録日2023-07-27
公開日2024-08-14
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Crystal Structure Analysis of BCL11A in complex with DNA
To Be Published
2A9U
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BU of 2a9u by Molmil
Structure of the N-terminal domain of Human Ubiquitin carboxyl-terminal hydrolase 8 (USP8)
分子名称: Ubiquitin carboxyl-terminal hydrolase 8
著者Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, E, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2005-07-12
公開日2005-08-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8).
J.Biol.Chem., 281, 2006
2KVR
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BU of 2kvr by Molmil
Solution NMR structure of human ubiquitin specific protease Usp7 UBL domain (residues 537-664). NESG target hr4395c/ SGC-Toronto
分子名称: Ubiquitin carboxyl-terminal hydrolase 7
著者Bezsonova, I, Lemak, A, Avvakumov, G, Xue, S, Dhe-Paganon, S, Montelione, G.T, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)
登録日2010-03-25
公開日2010-04-21
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献solution structure of the ubiquitin specific protease Usp7 ubiquitin-like domain
To be Published
2L76
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BU of 2l76 by Molmil
Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto
分子名称: NFATC2-interacting protein
著者Wu, B, Yee, A, Houliston, S, Doherty, R, Semesi, A, Dhe-Paganon, S, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Ontario Centre for Structural Proteomics (OCSP)
登録日2010-12-03
公開日2010-12-22
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Human NFATC2IP ubiquitin-like domains
To be Published
2L2D
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BU of 2l2d by Molmil
Solution NMR Structure of human UBA-like domain of OTUD7A_11_83, NESG target HT6304A/OCSP target OTUD7A_11_83/SGC-Toronto
分子名称: OTU domain-containing protein 7A
著者Wu, B, Yee, A, Lemak, A, Gutmanas, A, Houliston, S, Semesi, A, Dhe-Paganon, S, Montelione, G.T, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Ontario Centre for Structural Proteomics (OCSP), Structural Genomics Consortium (SGC)
登録日2010-08-17
公開日2010-09-01
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The amino-terminal UBA domain of OTUD7A
To be Published
2KR1
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BU of 2kr1 by Molmil
Solution NMR structure of zinc binding N-terminal domain of ubiquitin-protein ligase E3A from Homo Sapiens. Northeast Structural Genomics Consortium (NESG) target HR3662
分子名称: Ubiquitin protein ligase E3A, ZINC ION
著者Lemak, A, Yee, A, Fares, C, Semesi, A, Xiao, R, Montelione, G, Dhe-Paganon, S, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)
登録日2009-11-27
公開日2009-12-22
最終更新日2020-02-26
実験手法SOLUTION NMR
主引用文献Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A.
J.Biomol.Nmr, 51, 2011
2A2N
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BU of 2a2n by Molmil
Crystal Structure of the peptidylprolyl isomerase domain of Human PPWD1
分子名称: GLYCEROL, peptidylprolyl isomerase domain and WD repeat containing 1
著者Walker, J.R, Davis, T.L, Newman, E.M, Mackenzie, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2005-06-22
公開日2005-07-05
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1).
Febs J., 275, 2008
5JWM
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BU of 5jwm by Molmil
Bivalent BET Bromodomain Inhibition
分子名称: 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]ethanamide, Bromodomain-containing protein 4
著者Seo, H.-S, Dhe-Paganon, S.
登録日2016-05-12
公開日2016-07-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Design and characterization of bivalent BET inhibitors.
Nat.Chem.Biol., 12, 2016
2AWG
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BU of 2awg by Molmil
Structure of the PPIase domain of the Human FK506-binding protein 8
分子名称: 38 kDa FK-506 binding protein
著者Walker, J.R, Davis, T, Newman, E.M, Finerty, P, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2005-09-01
公開日2005-09-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of the human FK-506 binding protein 8
To be Published
6OSP
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BU of 6osp by Molmil
Crystal Structure Analysis of PIP4K2A
分子名称: 4-{[(2E)-4-(dimethylamino)but-2-enoyl]amino}-N-(3-{[6-(1H-indol-3-yl)pyrimidin-4-yl]amino}phenyl)benzamide, GLYCEROL, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
著者Seo, H.-S, Dhe-Paganon, S.
登録日2019-05-01
公開日2020-04-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.
Cell Chem Biol, 27, 2020
6MBZ
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BU of 6mbz by Molmil
Structure of Transcription Factor
分子名称: Signal transducer and activator of transcription 5B
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-08-30
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Structural and functional consequences of the STAT5BN642Hdriver mutation.
Nat Commun, 10, 2019
6MBW
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BU of 6mbw by Molmil
Structure of Transcription Factor
分子名称: Signal transducer and activator of transcription 5B
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-08-30
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.29 Å)
主引用文献Structural and functional consequences of the STAT5BN642H driver mutation.
Nat Commun, 10, 2019
6VQM
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BU of 6vqm by Molmil
Crystal Structure Analysis of human ACK1
分子名称: 2-({4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl}amino)-9-methyl-5,7-dihydro-6H-pyrimido[5,4-d][1,3]benzodiazepin-6-one, Activated CDC42 kinase 1, SULFATE ION
著者Seo, H.-S, Dhe-Paganon, S.
登録日2020-02-05
公開日2021-02-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Crystal Structure Analysis of human ACK1
To Be Published
6O33
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BU of 6o33 by Molmil
Crystal Structure Analysis of PIN1
分子名称: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION, peptide
著者Seo, H.-S, Dhe-Paganon, S.
登録日2019-02-25
公開日2020-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Crystal Structure Analysis of PIN1
To be Published
6O34
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BU of 6o34 by Molmil
Crystal Structure Analysis of PIN1
分子名称: GLYCEROL, NONAETHYLENE GLYCOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ...
著者Seo, H.-S, Dhe-Paganon, S.
登録日2019-02-25
公開日2020-02-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Crystal Structure Analysis of PIN1
To be Published
5BNH
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BU of 5bnh by Molmil
Crystal structure of the HLTF HIRAN domain with a ssDNA fragment
分子名称: ACETATE ION, DNA (5'-D(*(GD)P*GP*TP*G)-3'), DNA (5'-D(*(TD)P*TP*G)-3'), ...
著者Neculai, D, Walker, J.R, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Dhe-Paganon, S.
登録日2015-05-26
公開日2016-05-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Co-crystal structure of the HLTF HIRAN domain with a ssDNA fragment
To Be Published
5K5F
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BU of 5k5f by Molmil
NMR structure of the HLTF HIRAN domain
分子名称: Helicase-like transcription factor
著者Bezsonova, I, Neculai, D, Korzhnev, D, Weigelt, J, Bountra, C, Edwards, A, Arrowsmith, C, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2016-05-23
公開日2016-06-08
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NMR structure of the HLTF HIRAN domain
To Be Published
7KMR
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BU of 7kmr by Molmil
Crystal structure analysis of human KRAS mutant
分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas
著者Seo, H.-S, Dhe-Paganon, S.
登録日2020-11-03
公開日2021-11-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022
7LI5
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BU of 7li5 by Molmil
Crystal Structure Analysis of human TEAD1
分子名称: 1-[(3R,4R)-3-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]-4-{[4-(trifluoromethyl)phenyl]methoxy}pyrrolidin-1-yl]prop-2-en-1-one, SULFATE ION, Transcriptional enhancer factor TEF-1
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-01-26
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Crystal Structure Analysis of human TEAD1
To Be Published
7MKX
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BU of 7mkx by Molmil
Crystal Structure Analysis of human CDK2 and CCNA2 complex
分子名称: 2-[(5-bromo-2-{4-[(cyanomethyl)sulfamoyl]anilino}pyrimidin-4-yl)amino]-6-fluorobenzamide, Cyclin-A2, Cyclin-dependent kinase 2
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-04-27
公開日2022-11-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Crystal Structure Analysis of human CDK2 and CCNA2 complex
To Be Published
1IC8
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BU of 1ic8 by Molmil
HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT
分子名称: 5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*GP*A)-3', 5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*G)-3', HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
著者Chi, Y.-I, Frantz, J.D, Oh, B.-C, Hansen, L, Dhe-Paganon, S, Shoelson, S.E.
登録日2001-03-30
公開日2002-11-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Diabetes mutations delineate an atypical POU domains in HNF1-Alpha
Mol.Cell, 10, 2002
3KUL
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BU of 3kul by Molmil
Kinase domain of human ephrin type-A receptor 8 (EPHA8)
分子名称: BETA-MERCAPTOETHANOL, Ephrin type-A receptor 8, GLYCEROL, ...
著者Walker, J.R, Yermekbayeva, L, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2009-11-27
公開日2009-12-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Kinase Domain of Human Ephrin Type-A Receptor 8 (Epha8)
To be Published
7SZC
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BU of 7szc by Molmil
Crystal Structure Analysis of human PRPK complex with a compound
分子名称: 4-hydroxy-2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione, D(-)-TARTARIC ACID, EKC/KEOPS complex subunit TP53RK, ...
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-11-27
公開日2022-12-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Development of PRPK Directed Phthalimides
Biorxiv, 2021
7SZD
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BU of 7szd by Molmil
Crystal Structure Analysis of human PRPK complex with a compound
分子名称: 2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid, EKC/KEOPS complex subunit TP53RK, EKC/KEOPS complex subunit TPRKB
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-11-27
公開日2022-12-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Development of PRPK Directed Phthalimides
Biorxiv, 2021
7SZB
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BU of 7szb by Molmil
Crystal Structure Analysis of human PRPK complex with a compound
分子名称: 5-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione, CITRATE ANION, EKC/KEOPS complex subunit TP53RK, ...
著者Seo, H.-S, Dhe-Paganon, S.
登録日2021-11-27
公開日2023-01-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Development of PRPK Directed Phthalimides
Biorxiv, 2021

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