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PDB: 997 件
4KRR
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BU of 4krr by Molmil
Crystal structure of Drosophila WntD N-terminal domain-linker (residues 31-240)
分子名称: GLYCEROL, SODIUM ION, Wnt inhibitor of Dorsal protein
著者Chu, M.L.-H, Choi, H.-J, Ahn, V.E, Daniels, D.L, Nusse, R, Weis, W.I.
登録日2013-05-16
公開日2013-07-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.124 Å)
主引用文献Structural Studies of Wnts and Identification of an LRP6 Binding Site.
Structure, 21, 2013
1AAW
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BU of 1aaw by Molmil
THE STRUCTURAL BASIS FOR THE ALTERED SUBSTRATE SPECIFICITY OF THE R292D ACTIVE SITE MUTANT OF ASPARTATE AMINOTRANSFERASE FROM E. COLI
分子名称: ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
著者Almo, S.C, Smith, D.L, Danishefsky, A.T, Ringe, D.
登録日1993-07-13
公開日1993-10-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The structural basis for the altered substrate specificity of the R292D active site mutant of aspartate aminotransferase from E. coli.
Protein Eng., 7, 1994
4HXQ
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BU of 4hxq by Molmil
Crystal structure of human Arginase-1 complexed with inhibitor 14
分子名称: Arginase-1, MANGANESE (II) ION, [(5R)-5-carboxy-5-(methylamino)-7-(piperidin-1-yl)heptyl](trihydroxy)borate(1-)
著者Cousido-Siah, A, Mitschler, A, Ruiz, F.X, Whitehouse, D.L, Golebiowski, A, Ji, M, Zhang, M, Beckett, P, Sheeler, R, Andreoli, M, Conway, B, Mahboubi, K, Schroeter, H, Van Zandt, M.C, Podjarny, A.
登録日2012-11-12
公開日2013-03-20
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.
J.Med.Chem., 56, 2013
4HZE
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BU of 4hze by Molmil
Crystal structure of human Arginase-2 complexed with inhibitor 9
分子名称: Arginase-2, mitochondrial, BENZAMIDINE, ...
著者Cousido-Siah, A, Mitschler, A, Ruiz, F.X, Whitehouse, D.L, Golebiowski, A, Ji, M, Zhang, M, Beckett, P, Sheeler, R, Andreoli, M, Conway, B, Mahboubi, K, Schroeter, H, Van Zandt, M.C, Podjarny, A.
登録日2012-11-15
公開日2013-03-20
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.602 Å)
主引用文献Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.
J.Med.Chem., 56, 2013
2WEY
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BU of 2wey by Molmil
Human PDE-papaverine complex obtained by ligand soaking of cross- linked protein crystals
分子名称: 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE, CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE, ...
著者Andersen, O.A, Schonfeld, D.L, Toogood-Johnson, I, Felicetti, B, Albrecht, C, Fryatt, T, Whittaker, M, Hallett, D, Barker, J.
登録日2009-04-02
公開日2009-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Cross-Linking of Protein Crystals as an Aid in the Generation of Binary Protein-Ligand Crystal Complexes, Exemplified by the Human Pde10A-Papaverine Structure.
Acta Crystallogr.,Sect.D, 65, 2009
4IFD
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BU of 4ifd by Molmil
Crystal structure of an 11-subunit eukaryotic exosome complex bound to RNA
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BROMIDE ION, Exosome complex component CSL4, ...
著者Makino, D.L, Conti, E.
登録日2012-12-14
公開日2013-02-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.805 Å)
主引用文献Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex.
Nature, 495, 2013
2WTE
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BU of 2wte by Molmil
The structure of the CRISPR-associated protein, Csa3, from Sulfolobus solfataricus at 1.8 angstrom resolution.
分子名称: CSA3, DI(HYDROXYETHYL)ETHER
著者Lintner, N.G, Alsbury, D.L, Copie, V, Young, M.J, Lawrence, C.M.
登録日2009-09-15
公開日2010-09-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Structure of the Crispr-Associated Protein Csa3 Provides Insight Into the Regulation of the Crispr/Cas System.
J.Mol.Biol., 405, 2011
2WHJ
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BU of 2whj by Molmil
Understanding how diverse mannanases recognise heterogeneous substrates
分子名称: ACETATE ION, BETA-MANNANASE, GLYCEROL, ...
著者Tailford, L.E, Ducros, V.M.A, Flint, J.E, Roberts, S.M, Morland, C, Zechel, D.L, Smith, N, Bjornvad, M.E, Borchert, T.V, Wilson, K.S, Davies, G.J, Gilbert, H.J.
登録日2009-05-05
公開日2009-05-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Understanding How Diverse -Mannanases Recognise Heterogeneous Substrates.
Biochemistry, 48, 2009
2WJ2
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BU of 2wj2 by Molmil
3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole
分子名称: 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptane-1,1-diol, CHLORIDE ION, FATTY ACID AMIDE HYDROLASE 1
著者Mileni, M, Garfunkle, J, DeMartino, J.K, Cravatt, B.F, Boger, D.L, Stevens, R.C.
登録日2009-05-19
公開日2009-09-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures.
J.Am.Chem.Soc., 131, 2009
2WJ1
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BU of 2wj1 by Molmil
3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(4-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole
分子名称: 7-phenyl-1-(4-pyridin-2-yl-1,3-oxazol-2-yl)heptane-1,1-diol, CHLORIDE ION, FATTY-ACID AMIDE HYDROLASE 1
著者Mileni, M, Garfunkle, J, DeMartino, J.K, Cravatt, B.F, Boger, D.L, Stevens, R.C.
登録日2009-05-19
公開日2009-09-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures.
J.Am.Chem.Soc., 131, 2009
6B8N
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BU of 6b8n by Molmil
Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak
分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 4, ...
著者Chang, A, Minor, D.L.
登録日2017-10-09
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献A Calmodulin C-Lobe Ca
Neuron, 97, 2018
6BA8
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BU of 6ba8 by Molmil
YbtT - Type II thioesterase from Yersiniabactin NRPS/PKS biosynthetic pathway
分子名称: Iron aquisition yersiniabactin synthesis enzyme, YbtT
著者Brett, T.J, Kober, D.L, Ohlemacher, S.I, Henderson, J.P.
登録日2017-10-12
公開日2018-10-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria.
J. Biol. Chem., 293, 2018
6AOD
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BU of 6aod by Molmil
FXIa antibody complex
分子名称: COBALT (II) ION, Coagulation factor XI, FXIa Antibody FAB Heavy Chain, ...
著者Lolicato, M, Minor, D.L.
登録日2017-08-15
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.
Structure, 26, 2018
6BEV
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BU of 6bev by Molmil
Human Single Domain Sulfurtranferase TSTD1
分子名称: Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1
著者Motl, N, Akey, D.L, Smith, J.L, Banerjee, R.
登録日2017-10-25
公開日2018-01-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.043 Å)
主引用文献Thiosulfate sulfurtransferase-like domain-containing 1 protein interacts with thioredoxin.
J. Biol. Chem., 293, 2018
6B8M
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BU of 6b8m by Molmil
Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak
分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 4, ...
著者Chang, A, Minor, D.L.
登録日2017-10-09
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A Calmodulin C-Lobe Ca
Neuron, 97, 2018
6B8Q
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BU of 6b8q by Molmil
Crystal Structure of the Mg2+/CaM:Kv7.5 (KCNQ5) AB domain complex
分子名称: Calmodulin-1, MAGNESIUM ION, Potassium voltage-gated channel subfamily KQT member 5
著者Chang, A, Abderemane-Ali, F, Minor, D.L.
登録日2017-10-09
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Calmodulin C-Lobe Ca
Neuron, 97, 2018
6B8P
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BU of 6b8p by Molmil
Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex
分子名称: Calmodulin-1, MAGNESIUM ION, Potassium voltage-gated channel subfamily KQT member 4, ...
著者Chang, A, Minor, D.L.
登録日2017-10-09
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A Calmodulin C-Lobe Ca
Neuron, 97, 2018
6BA9
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BU of 6ba9 by Molmil
YbtT - Type II thioesterase from Yersiniabactin NRPS/PKS biosynthetic pathway- S89A mutant
分子名称: Iron aquisition yersiniabactin synthesis enzyme, YbtT
著者Brett, T.J, Kober, D.L, Ohlemacher, S.I, Henderson, J.P.
登録日2017-10-12
公開日2018-10-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria.
J. Biol. Chem., 293, 2018
6CQ6
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BU of 6cq6 by Molmil
K2P2.1(TREK-1) apo structure
分子名称: CADMIUM ION, DECANE, POTASSIUM ION, ...
著者Lolicato, M, Minor, D.L.
登録日2018-03-14
公開日2018-03-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017
6CQ9
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BU of 6cq9 by Molmil
K2P2.1(TREK-1):ML402 complex
分子名称: CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ...
著者Lolicato, M, Minor, D.L.
登録日2018-03-14
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017
6CQ8
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BU of 6cq8 by Molmil
K2P2.1(TREK-1):ML335 complex
分子名称: CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ...
著者Lolicato, M, Minor, D.L.
登録日2018-03-14
公開日2018-03-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017
6B8L
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BU of 6b8l by Molmil
Crystal Structure of the Apo/CaM:Kv7.4 (KCNQ4) AB Domain Complex
分子名称: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 4, SULFATE ION
著者Chang, A, Abderemane-Ali, F, Minor, D.L.
登録日2017-10-09
公開日2018-03-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function
Neuron, 97, 2018
6BX4
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BU of 6bx4 by Molmil
The crystal structure of fluoride channel Fluc Ec2 with Monobody S9
分子名称: DECYL-BETA-D-MALTOPYRANOSIDE, FLUORIDE ION, Fluoride ion transporter CrcB, ...
著者Turman, D.L, Miller, C.
登録日2017-12-16
公開日2018-02-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Molecular Interactions between a Fluoride Ion Channel and Synthetic Protein Blockers.
Biochemistry, 57, 2018
6BX5
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BU of 6bx5 by Molmil
The crystal structure of fluoride channel Fluc Ec2 with Monobody S12
分子名称: FLUORIDE ION, Monobody S12, Putative fluoride ion transporter CrcB, ...
著者Turman, D.L, Miller, C.
登録日2017-12-17
公開日2018-02-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Molecular Interactions between a Fluoride Ion Channel and Synthetic Protein Blockers.
Biochemistry, 57, 2018
6CT6
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BU of 6ct6 by Molmil
Crystal structure of lactate dehydrogenase from Eimeria maxima with NADH and oxamate
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Lactate dehydrogenase, OXAMIC ACID, ...
著者Wirth, J.D, Xu, C, Theobald, D.L.
登録日2018-03-22
公開日2019-03-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.705 Å)
主引用文献The Mechanistic, Structural, and Evolutionary Origin of Lactate Dehydrogenase Substrate Specificity in Apicomplexa
To Be Published

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件を2024-10-09に公開中

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