4UUM
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4UUN
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5DG5
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![BU of 5dg5 by Molmil](/molmil-images/mine/5dg5) | CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157 | 分子名称: | Hepatocyte growth factor receptor, N-(2,5-difluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxam ide | 著者 | Smith, B.D, Kaufman, M.D, Leary, C.B, Turner, B.A, Wise, S.A, Ahn, Y.M, Booth, R.J, Caldwell, T.M, Ensinger, C.L, Hood, M.M, Lu, W.-P, Patt, T.W, Patt, W.C, Rutkoski, T.J, Samarakoon, T, Telikepalli, H, Vogeti, L, Vogeti, S, Yates, K.M, Chun, L, Stewart, L.J, Clare, M, Flynn, D.L. | 登録日 | 2015-08-27 | 公開日 | 2016-08-31 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2. Mol.Cancer Ther., 14, 2015
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5N82
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![BU of 5n82 by Molmil](/molmil-images/mine/5n82) | Crystal structure of an engineered TycA variant in complex with an beta-Phe-AMP analog | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, Tyrocidine synthase 1, ... | 著者 | Niquille, D.L, Hansen, D.L, Mori, T, Fercher, D, Kries, H, Hilvert, D. | 登録日 | 2017-02-22 | 公開日 | 2017-12-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.708 Å) | 主引用文献 | Nonribosomal biosynthesis of backbone-modified peptides. Nat Chem, 10, 2018
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4O6D
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![BU of 4o6d by Molmil](/molmil-images/mine/4o6d) | West Nile Virus Non-structural protein 1 (NS1) Form 1 crystal | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NS1, ... | 著者 | Akey, D.L, Smith, J.L. | 登録日 | 2013-12-20 | 公開日 | 2014-02-19 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.5936 Å) | 主引用文献 | Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system. Science, 343, 2014
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4O6B
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5VHU
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4F11
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![BU of 4f11 by Molmil](/molmil-images/mine/4f11) | Crystal structure of the extracellular domain of human GABA(B) receptor GBR2 | 分子名称: | Gamma-aminobutyric acid type B receptor subunit 2 | 著者 | Geng, Y, Xiong, D, Mosyak, L, Malito, D.L, Kniazeff, J, Chen, Y, Burmakina, S, Quick, M, Bush, M, Javitch, J.A, Pin, J.-P, Fan, Q.R. | 登録日 | 2012-05-05 | 公開日 | 2012-06-06 | 最終更新日 | 2012-08-15 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2. Nat.Neurosci., 15, 2012
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2FRC
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![BU of 2frc by Molmil](/molmil-images/mine/2frc) | CYTOCHROME C (REDUCED) FROM EQUUS CABALLUS, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | CYTOCHROME C, HEME C | 著者 | Qi, P.X, Di Stefano, D.L, Wand, A.J. | 登録日 | 1996-07-02 | 公開日 | 1997-07-29 | 最終更新日 | 2017-11-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of horse heart ferricytochrome c and detection of redox-related structural changes by high-resolution 1H NMR. Biochemistry, 35, 1996
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4FNG
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![BU of 4fng by Molmil](/molmil-images/mine/4fng) | The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina | 分子名称: | E3 alpha-esterase-7 caboxylesterase | 著者 | Jackson, C.J, Liu, J.-W, Carr, P.D, Younis, F, Pandey, G, Coppin, C, Meirelles, T, Ollis, D.L, Tawfik, D.S, Weik, M, Oakeshott, J.G. | 登録日 | 2012-06-19 | 公開日 | 2013-06-19 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure and function of an insect alpha-carboxylesterase ( alpha Esterase7) associated with insecticide resistance. Proc.Natl.Acad.Sci.USA, 110, 2013
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2FSU
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![BU of 2fsu by Molmil](/molmil-images/mine/2fsu) | Crystal Structure of the PhnH Protein from Escherichia Coli | 分子名称: | ACETATE ION, Protein phnH, SODIUM ION | 著者 | Adams, M.A, Luo, Y, Zechel, D.L, Jia, Z, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | 登録日 | 2006-01-23 | 公開日 | 2007-03-27 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of PhnH: an essential component of carbon-phosphorus lyase in Escherichia coli. J.Bacteriol., 190, 2008
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5VRF
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![BU of 5vrf by Molmil](/molmil-images/mine/5vrf) | CryoEM Structure of the Zinc Transporter YiiP from helical crystals | 分子名称: | Cadmium and zinc efflux pump FieF, ZINC ION | 著者 | Coudray, N, Lopez-Redondo, M, Zhang, Z, Alexopoulos, J, Stokes, D.L, Transcontinental EM Initiative for Membrane Protein Structure (TEMIMPS) | 登録日 | 2017-05-10 | 公開日 | 2018-03-14 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis for the alternating access mechanism of the cation diffusion facilitator YiiP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4FET
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![BU of 4fet by Molmil](/molmil-images/mine/4fet) | Catalytic domain of germination-specific lytic tansglycosylase SleB from Bacillus anthracis | 分子名称: | SODIUM ION, Spore cortex-lytic enzyme prepeptide | 著者 | Jing, X, Heffron, J, Popham, D.L, Schubot, F.D. | 登録日 | 2012-05-30 | 公開日 | 2012-07-25 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.909 Å) | 主引用文献 | The catalytic domain of the germination-specific lytic transglycosylase SleB from Bacillus anthracis displays a unique active site topology. Proteins, 80, 2012
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4FNM
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![BU of 4fnm by Molmil](/molmil-images/mine/4fnm) | The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina | 分子名称: | DIETHYL HYDROGEN PHOSPHATE, E3 alpha-esterase-7 carboxylesterase | 著者 | Jackson, C.J, Liu, J.-W, Carr, P.D, Younis, F, Pandey, G, Coppin, C, Meirelles, T, Ollis, D.L, Tawfik, D.S, Weik, M, Oakeshott, J.G. | 登録日 | 2012-06-20 | 公開日 | 2013-12-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.804 Å) | 主引用文献 | Structure and function of an insect alpha-carboxylesterase ( alpha Esterase7) associated with insecticide resistance. Proc.Natl.Acad.Sci.USA, 110, 2013
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5K6K
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![BU of 5k6k by Molmil](/molmil-images/mine/5k6k) | Zika virus non-structural protein 1 (NS1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... | 著者 | Akey, D.L, Brown, W.C, Smith, J.L. | 登録日 | 2016-05-24 | 公開日 | 2016-07-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Extended surface for membrane association in Zika virus NS1 structure. Nat.Struct.Mol.Biol., 23, 2016
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7XTY
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![BU of 7xty by Molmil](/molmil-images/mine/7xty) | Crystal Structure of the second PDZ domain from human PTPN13 in complex with APC peptide | 分子名称: | APC-peptide, Tyrosine-protein phosphatase non-receptor type 13 | 著者 | Jing, L.Q, Sun, X.N, Ma, W.H, Zhou, W.J, Wu, D.L. | 登録日 | 2022-05-18 | 公開日 | 2023-05-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Targeting PTPN13 with 11 amino acid peptides of C-terminal APC prevents immune evasion of colorectal cancer to be published
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3V0D
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![BU of 3v0d by Molmil](/molmil-images/mine/3v0d) | Crystal structure of Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP), residues 241-576(C363S) | 分子名称: | PHOSPHATE ION, Voltage-sensor containing phosphatase | 著者 | Liu, L, Kohout, S.C, Xu, Q, Muller, S, Kimberlin, C, Isacoff, E.Y, Minor, D.L. | 登録日 | 2011-12-07 | 公開日 | 2012-05-09 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | A glutamate switch controls voltage-sensitive phosphatase function. Nat.Struct.Mol.Biol., 19, 2012
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3UP0
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![BU of 3up0 by Molmil](/molmil-images/mine/3up0) | Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid | 分子名称: | (5beta,14beta,17alpha,25S)-3-oxocholest-7-en-26-oic acid, Nuclear receptor coactivator 2, aceDAF-12 | 著者 | Zhi, X, Zhou, X.E, Melcher, K, Motola, D.L, Gelmedin, V, Hawdon, J, Kliewer, S.A, Mangelsdorf, D.J, Xu, H.E. | 登録日 | 2011-11-17 | 公開日 | 2011-12-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes. J.Biol.Chem., 287, 2012
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1VZB
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8E0E
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![BU of 8e0e by Molmil](/molmil-images/mine/8e0e) | nbF3:CaV beta subunit 2a complex | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, GLYCEROL, ... | 著者 | Nirwan, N, Minor, D.L. | 登録日 | 2022-08-09 | 公開日 | 2023-01-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Selective posttranslational inhibition of Ca V beta 1 -associated voltage-dependent calcium channels with a functionalized nanobody. Nat Commun, 13, 2022
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3GYT
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![BU of 3gyt by Molmil](/molmil-images/mine/3gyt) | Nuclear receptor DAF-12 from parasitic nematode Strongyloides stercoralis in complex with its physiological ligand dafachronic acid delta 4 | 分子名称: | (14beta,17alpha,25R)-3-oxocholest-4-en-26-oic acid, Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily, SRC1 | 著者 | Zhou, X.E, Wang, Z, Suino-Powell, K, Motola, D.L, Conneely, A, Ogata, C, Sharma, K.K, Auchus, R.J, Kliewer, S.A, Xu, H.E, Mangelsdorf, D.J. | 登録日 | 2009-04-05 | 公開日 | 2009-07-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proc.Natl.Acad.Sci.USA, 106, 2009
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1VZE
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![BU of 1vze by Molmil](/molmil-images/mine/1vze) | L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q TERNARY COMPLEX WITH DUMP AND CB3717 | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | 著者 | Birdsall, D.L, Finer-Moore, J, Stroud, R.M. | 登録日 | 1996-09-18 | 公開日 | 1997-03-12 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. Protein Eng., 11, 1998
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1VZD
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![BU of 1vzd by Molmil](/molmil-images/mine/1vzd) | L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q TERNARY COMPLEX WITH FDUMP AND CB3717 | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | 著者 | Birdsall, D.L, Finer-Moore, J, Stroud, R.M. | 登録日 | 1996-09-18 | 公開日 | 1997-03-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. Protein Eng., 11, 1998
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1VZC
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1VZA
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