3UP0

Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid

Summary for 3UP0

Related3UP3
DescriptoraceDAF-12, Nuclear receptor coactivator 2, (5beta,14beta,17alpha,25S)-3-oxocholest-7-en-26-oic acid, ... (4 entities in total)
Functional Keywordsnematode, steroid binding protein-transcription complex, steroid binding protein/transcription
Biological sourceAncylostoma ceylanicum
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Cellular locationNucleus Q15596
Total number of polymer chains4
Total molecular weight59788.58
Authors
Zhi, X.,Zhou, X.E.,Melcher, K.,Motola, D.L.,Gelmedin, V.,Hawdon, J.,Kliewer, S.A.,Mangelsdorf, D.J.,Xu, H.E. (deposition date: 2011-11-17, release date: 2011-12-14, Last modification date: 2012-02-29)
Primary citation
Zhi, X.,Zhou, X.E.,Melcher, K.,Motola, D.L.,Gelmedin, V.,Hawdon, J.,Kliewer, S.A.,Mangelsdorf, D.J.,Xu, H.E.
Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes.
J.Biol.Chem., 287:4894-4903, 2012
PubMed: 22170062 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M111.315242
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.208301.3%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3up0
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Molmil generated image of 3up0
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More Biological unit images

Molmil generated image of 3up0
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Molmil generated image of 3up0
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Molmil generated image of 3up0
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3up0.pdb2.gz [48.94 KB])
Coordinate files for Biological unit (3up0.pdb1.gz [49 KB])