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3UP0

Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0030154biological_processcell differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0030154biological_processcell differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE D7S A 100
ChainResidue
AHOH46
APHE560
AGLN571
AILE657
ASER661
ALEU664
AHOH72
ATHR495
ALEU529
ATHR530
AARG532
AGLY533
ATHR546
AMET559

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE D7S B 200
ChainResidue
BHOH43
BTHR495
BLEU529
BTHR530
BARG532
BGLY533
BTHR546
BPRO547
BMET559
BPHE560
BGLN571
BILE657
BLEU664

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PDB entries from 2024-03-27

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