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PDB: 22172 results
7B20
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BU of 7b20 by Molmil
DtxR-like iron-dependent regulator IdeR complexed with iron and its consensus DNA-binding sequence
Descriptor: DtxR family iron (Metal) dependent repressor, FE (II) ION, consensus DNA-binding sequence
Authors:Maurer, D, Marcos-Torres, F.J, Griese, J.J.
Deposit date:2020-11-25
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:The bacterial iron sensor IdeR recognizes its DNA targets by indirect readout.
Nucleic Acids Res., 49, 2021
7B1V
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BU of 7b1v by Molmil
DtxR-like iron-dependent regulator IdeR complexed with cobalt
Descriptor: COBALT (II) ION, DtxR family iron (Metal) dependent repressor
Authors:Maurer, D, Marcos-Torres, F.J, Griese, J.J.
Deposit date:2020-11-25
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:The bacterial iron sensor IdeR recognizes its DNA targets by indirect readout.
Nucleic Acids Res., 49, 2021
5XZR
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BU of 5xzr by Molmil
The atomic structure of SHP2 E76A mutant in complex with allosteric inhibitor 9b
Descriptor: 4-(3-phenylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3-thiazol-2-amine, Tyrosine-protein phosphatase non-receptor type 11
Authors:Li, D, Xie, J, Zhu, J, Liu, C.
Deposit date:2017-07-13
Release date:2017-12-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
J. Med. Chem., 60, 2017
8RS5
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BU of 8rs5 by Molmil
Crystal structure of Methanopyrus kandleri malate dehydrogenase mutant 4
Descriptor: CHLORIDE ION, Malate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Coquille, S, Engilberge, S, Madern, D.
Deposit date:2024-01-24
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Navigating the conformational landscape of an enzyme. Stabilization of a low populated conformer by evolutionary mutations triggers Allostery into a non-allosteric enzyme.
To Be Published
5Y0E
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BU of 5y0e by Molmil
Crystal structure of TssK
Descriptor: SULFATE ION, TssK
Authors:Tong, H, Xu, D, Ran, T, Wang, W.W.
Deposit date:2017-07-17
Release date:2018-08-08
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of TssK at 2.5 Angstroms resolution.
To Be Published
7B25
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BU of 7b25 by Molmil
DtxR-like iron-dependent regulator IdeR (Q43A variant) complexed with cobalt and its consensus DNA-binding sequence
Descriptor: COBALT (II) ION, DtxR family iron (Metal) dependent repressor, consensus DNA-binding sequence
Authors:Maurer, D, Marcos-Torres, F.J, Griese, J.J.
Deposit date:2020-11-26
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:The bacterial iron sensor IdeR recognizes its DNA targets by indirect readout.
Nucleic Acids Res., 49, 2021
7AHI
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BU of 7ahi by Molmil
Substrate-engaged type 3 secretion system needle complex from Salmonella enterica typhimurium - SpaR state 2
Descriptor: 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, LAURYL DIMETHYLAMINE-N-OXIDE, Lipoprotein PrgK, ...
Authors:Fahrenkamp, D, Goessweiner-Mohr, N, Miletic, S, Wald, J, Marlovits, T.
Deposit date:2020-09-24
Release date:2021-03-17
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation
Nat Commun, 12, 2021
7SY7
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BU of 7sy7 by Molmil
Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417T mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Kim, A, Li, W, Dimitrov, D.S, Subramaniam, S.
Deposit date:2021-11-24
Release date:2021-12-29
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding.
Cell Rep, 37, 2021
7SY4
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BU of 7sy4 by Molmil
Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Kim, A, Li, W, Dimitrov, D.S, Subramaniam, S.
Deposit date:2021-11-24
Release date:2021-12-29
Last modified:2022-01-05
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding.
Cell Rep, 37, 2021
7T9J
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BU of 7t9j by Molmil
Cryo-EM structure of the SARS-CoV-2 Omicron spike protein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Tuttle, K.S, Subramaniam, S.
Deposit date:2021-12-19
Release date:2021-12-29
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex.
Science, 375, 2022
7SY6
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BU of 7sy6 by Molmil
Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417N mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Kim, A, Li, W, Dimitrov, D.S, Subramaniam, S.
Deposit date:2021-11-24
Release date:2021-12-29
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding.
Cell Rep, 37, 2021
7T9K
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BU of 7t9k by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron spike protein in complex with human ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Tuttle, K.S, Subramaniam, S.
Deposit date:2021-12-19
Release date:2021-12-29
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (2.45 Å)
Cite:SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex.
Science, 375, 2022
7SY5
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BU of 7sy5 by Molmil
Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417N mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Kim, A, Li, W, Dimitrov, D.S, Subramaniam, S.
Deposit date:2021-11-24
Release date:2021-12-29
Last modified:2022-01-05
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding.
Cell Rep, 37, 2021
8DI5
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BU of 8di5 by Molmil
Cryo-EM structure of SARS-CoV-2 Beta (B.1.351) spike protein in complex with VH domain F6 (focused refinement of RBD and VH F6)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, VH F6
Authors:Zhu, X, Saville, J.W, Mannar, D, Berezuk, A.M, Subramaniam, S.
Deposit date:2022-06-28
Release date:2022-08-24
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains.
Iscience, 25, 2022
7SXT
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BU of 7sxt by Molmil
Cryo-EM structure of the SARS-CoV-2 D614G,N501Y mutant spike protein ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Kim, A, Li, W, Dimitrov, D.S, Subramaniam, S.
Deposit date:2021-11-24
Release date:2021-12-29
Last modified:2022-01-05
Method:ELECTRON MICROSCOPY (2.31 Å)
Cite:Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding.
Cell Rep, 37, 2021
8CXQ
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BU of 8cxq by Molmil
SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-22
Descriptor: Spike glycoprotein, pan-sarbecovirus nanobody 1-22
Authors:Huang, W, Taylor, D.
Deposit date:2022-05-22
Release date:2022-07-06
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Superimmunity by pan-sarbecovirus nanobodies.
Cell Rep, 39, 2022
7SXS
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BU of 7sxs by Molmil
Cryo-EM structure of the SARS-CoV-2 D614G,L452R mutant spike protein ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Kim, A, Li, W, Dimitrov, D.S, Subramaniam, S.
Deposit date:2021-11-24
Release date:2021-12-29
Last modified:2022-01-05
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding.
Cell Rep, 37, 2021
1AZ1
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BU of 1az1 by Molmil
ALRESTATIN BOUND TO C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
Descriptor: ALDOSE REDUCTASE, ALRESTATIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Harrison, D.H.T, Bohren, K.M, Petsko, G.A, Ringe, D, Gabbay, K.H.
Deposit date:1997-11-24
Release date:1998-03-18
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
Biochemistry, 36, 1997
8CY6
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BU of 8cy6 by Molmil
SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-65
Descriptor: Spike glycoprotein, pan-sarbecovirus nanobody 2-65
Authors:Huang, W, Taylor, D.
Deposit date:2022-05-23
Release date:2022-07-06
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Superimmunity by pan-sarbecovirus nanobodies.
Cell Rep, 39, 2022
8DLK
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BU of 8dlk by Molmil
Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Subramaniam, S.
Deposit date:2022-07-08
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization.
Nat Commun, 13, 2022
8CYC
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BU of 8cyc by Molmil
SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-34
Descriptor: Spike glycoprotein, pan-sarbecovirus nanobody 2-34
Authors:Huang, W, Taylor, D.
Deposit date:2022-05-23
Release date:2022-07-06
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Superimmunity by pan-sarbecovirus nanobodies.
Cell Rep, 39, 2022
7SY3
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BU of 7sy3 by Molmil
Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Kim, A, Li, W, Dimitrov, D.S, Subramaniam, S.
Deposit date:2021-11-24
Release date:2021-12-29
Last modified:2022-01-05
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding.
Cell Rep, 37, 2021
8DLS
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BU of 8dls by Molmil
Cryo-EM structure of SARS-CoV-2 Gamma (P.1) spike protein in complex with Fab 4A8 (focused refinement of NTD and 4A8)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 4A8 heavy chain, ...
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Subramaniam, S.
Deposit date:2022-07-08
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization.
Nat Commun, 13, 2022
7T9L
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BU of 7t9l by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Tuttle, K.S, Subramaniam, S.
Deposit date:2021-12-19
Release date:2021-12-29
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex.
Science, 375, 2022
8DLV
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BU of 8dlv by Molmil
Cryo-EM structure of SARS-CoV-2 Epsilon (B.1.429) spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein
Authors:Zhu, X, Mannar, D, Saville, J.W, Srivastava, S.S, Berezuk, A.M, Zhou, S, Tuttle, K.S, Subramaniam, S.
Deposit date:2022-07-08
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization.
Nat Commun, 13, 2022

222415

數據於2024-07-10公開中

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