7SY5

Cryo-EM structure of the SARS-CoV-2 D614G,N501Y,E484K,K417N mutant spike protein ectodomain bound to human ACE2 ectodomain (global refinement)

Summary for 7SY5

• Entry DOI: 10.2210/pdb7sy5/pdb
• EMDB information: 25517
• Descriptor: Spike glycoprotein, Processed angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: sars-cov-2, glycoprotein, fusion protein, viral protein, ace2, viral protein-hydrolase complex, viral protein/hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 6
• Total formula weight: 655301.29

Authors

Zhu, X.,Mannar, D.,Saville, J.W.,Srivastava, S.S.,Berezuk, A.M.,Zhou, S.,Tuttle, K.S.,Kim, A.,Li, W.,Dimitrov, D.S.,Subramaniam, S. (deposition date: 2021-11-24, release date: 2021-12-29, Last modification date: 2022-01-05)

• Primary citation: Mannar, D.,Saville, J.W.,Zhu, X.,Srivastava, S.S.,Berezuk, A.M.,Zhou, S.,Tuttle, K.S.,Kim, A.,Li, W.,Dimitrov, D.S.,Subramaniam, S.; Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding.; Cell Rep, 37:110156-110156, 2021; PubMed: 34914928; DOI: 10.1016/j.celrep.2021.110156

Experimental method

ELECTRON MICROSCOPY (2.59 Å)