2ERL
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![BU of 2erl by Molmil](/molmil-images/mine/2erl) | PHEROMONE ER-1 FROM | Descriptor: | ETHANOL, MATING PHEROMONE ER-1 | Authors: | Anderson, D.H, Weiss, M.S, Eisenberg, D. | Deposit date: | 1995-12-20 | Release date: | 1996-07-11 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | A challenging case for protein crystal structure determination: the mating pheromone Er-1 from Euplotes raikovi. Acta Crystallogr.,Sect.D, 52, 1996
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2EZ1
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![BU of 2ez1 by Molmil](/molmil-images/mine/2ez1) | Holo tyrosine phenol-lyase from Citrobacter freundii at pH 8.0 | Descriptor: | POTASSIUM ION, Tyrosine phenol-lyase | Authors: | Milic, D, Matkovic-Calogovic, D, Demidkina, T.V, Antson, A.A. | Deposit date: | 2005-11-10 | Release date: | 2006-07-25 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of apo- and holo-tyrosine phenol-lyase reveal a catalytically critical closed conformation and suggest a mechanism for activation by K+ ions Biochemistry, 45, 2006
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2F8U
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![BU of 2f8u by Molmil](/molmil-images/mine/2f8u) | G-quadruplex structure formed in human Bcl-2 promoter, hybrid form | Descriptor: | 5'-D(*GP*GP*GP*CP*GP*CP*GP*GP*GP*AP*GP*GP*AP*AP*TP*TP*GP*GP*GP*CP*GP*GP*G)-3' | Authors: | Dai, J, Chen, D, Carver, M, Yang, D. | Deposit date: | 2005-12-03 | Release date: | 2006-11-07 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region. Nucleic Acids Res., 34, 2006
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2CJA
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![BU of 2cja by Molmil](/molmil-images/mine/2cja) | Crystal structure of Methanosarcina barkeri seryl-tRNA synthetase complexed with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Bilokapic, S, Maier, T, Ahel, D, Gruic-Sovulj, I, Soll, D, Weygand-Durasevic, I, Ban, N. | Deposit date: | 2006-03-30 | Release date: | 2006-06-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the Unusual Seryl-tRNA Synthetase Reveals a Distinct Zinc-Dependent Mode of Substrate Recognition Embo J., 25, 2006
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2CIM
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![BU of 2cim by Molmil](/molmil-images/mine/2cim) | Crystal structure of Methanosarcina barkeri seryl-tRNA synthetase | Descriptor: | CHLORIDE ION, PLATINUM (II) ION, SERYL-TRNA SYNTHETASE, ... | Authors: | Bilokapic, S, Maier, T, Ahel, D, Gruic-Sovulj, I, Soll, D, Weygand-Durasevic, I, Ban, N. | Deposit date: | 2006-03-24 | Release date: | 2006-06-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structure of the Unusual Seryl-tRNA Synthetase Reveals a Distinct Zinc-Dependent Mode of Substrate Recognition Embo J., 25, 2006
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1LJM
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![BU of 1ljm by Molmil](/molmil-images/mine/1ljm) | DNA recognition is mediated by conformational transition and by DNA bending | Descriptor: | CHLORIDE ION, RUNX1 transcription factor | Authors: | Bartfeld, D, Shimon, L, Couture, G.C, Rabinovich, D, Frolow, F, Levanon, D, Groner, Y, Shakked, Z. | Deposit date: | 2002-04-22 | Release date: | 2002-11-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | DNA Recognition by the RUNX1 Transcription Factor Is Mediated by an Allosteric Transition in the RUNT Domain and by DNA Bending. Structure, 10
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2CJB
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![BU of 2cjb by Molmil](/molmil-images/mine/2cjb) | Crystal structure of Methanosarcina barkeri seryl-tRNA synthetase complexed with serine | Descriptor: | CHLORIDE ION, SERINE, SERYL-TRNA SYNTHETASE, ... | Authors: | Bilokapic, S, Maier, T, Ahel, D, Gruic-Sovulj, I, Soll, D, Weygand-Durasevic, I, Ban, N. | Deposit date: | 2006-03-30 | Release date: | 2006-06-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of the Unusual Seryl-tRNA Synthetase Reveals a Distinct Zinc-Dependent Mode of Substrate Recognition Embo J., 25, 2006
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4ZZX
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![BU of 4zzx by Molmil](/molmil-images/mine/4zzx) | Structure of PARP2 catalytic domain bound to an isoindolinone inhibitor | Descriptor: | 2-(3-methoxypropyl)-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide, POLY [ADP-RIBOSE] POLYMERASE 2 | Authors: | Casale, E, Fasolini, M, Papeo, G, Posteri, H, Borghi, D, Busel, A.A, Caprera, F, Ciomei, M, Cirla, A, Corti, E, DAnello, M, Fasolini, M, Felder, E.R, Forte, B, Galvani, A, Isacchi, A, Khvat, A, Krasavin, M.Y, Lupi, R, Orsini, P, Perego, R, Pesenti, E, Pezzetta, D, Rainoldi, S, RiccardiSirtori, F, Scolaro, A, Sola, F, Zuccotto, F, Donati, D, Montagnoli, A. | Deposit date: | 2015-04-15 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Discovery of 2-[1-(4,4-Difluorocyclohexyl)Piperidin-4-Yl]-6-Fluoro-3-Oxo-2,3-Dihydro-1H-Isoindole-4-Carboxamide (Nms-P118): A Potent, Orally Available and Highly Selective Parp- 1 Inhibitor for Cancer Therapy. J.Med.Chem., 58, 2015
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4ZWJ
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![BU of 4zwj by Molmil](/molmil-images/mine/4zwj) | Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser | Descriptor: | Chimera protein of human Rhodopsin, mouse S-arrestin, and T4 Endolysin | Authors: | Kang, Y, Zhou, X.E, Gao, X, He, Y, Liu, W, Ishchenko, A, Barty, A, White, T.A, Yefanov, O, Han, G.W, Xu, Q, de Waal, P.W, Ke, J, Tan, M.H.E, Zhang, C, Moeller, A, West, G.M, Pascal, B, Eps, N.V, Caro, L.N, Vishnivetskiy, S.A, Lee, R.J, Suino-Powell, K.M, Gu, X, Pal, K, Ma, J, Zhi, X, Boutet, S, Williams, G.J, Messerschmidt, M, Gati, C, Zatsepin, N.A, Wang, D, James, D, Basu, S, Roy-Chowdhury, S, Conrad, C, Coe, J, Liu, H, Lisova, S, Kupitz, C, Grotjohann, I, Fromme, R, Jiang, Y, Tan, M, Yang, H, Li, J, Wang, M, Zheng, Z, Li, D, Howe, N, Zhao, Y, Standfuss, J, Diederichs, K, Dong, Y, Potter, C.S, Carragher, B, Caffrey, M, Jiang, H, Chapman, H.N, Spence, J.C.H, Fromme, P, Weierstall, U, Ernst, O.P, Katritch, V, Gurevich, V.V, Griffin, P.R, Hubbell, W.L, Stevens, R.C, Cherezov, V, Melcher, K, Xu, H.E, GPCR Network (GPCR) | Deposit date: | 2015-05-19 | Release date: | 2015-07-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.302 Å) | Cite: | Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature, 523, 2015
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5A8Y
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![BU of 5a8y by Molmil](/molmil-images/mine/5a8y) | Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, MALONATE ION, ... | Authors: | vonNussbaum, F, Li, V.M, Meibom, D, Anlauf, S, Bechem, M, Delbeck, M, Gerisch, M, Harrenga, A, Karthaus, D, Lang, D, Lustig, K, Mittendorf, J, Schaefer, M, Schaefer, S, Schamberger, J. | Deposit date: | 2015-07-17 | Release date: | 2016-08-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: In Vivo Efficacy of the Polar Pyrimidopyridazine Bay-8040 in a Pulmonary Arterial Hypertension Rat Model. Chemmedchem, 11, 2016
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2FLD
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![BU of 2fld by Molmil](/molmil-images/mine/2fld) | I-MsoI Re-Designed for Altered DNA Cleavage Specificity | Descriptor: | 5'-D(*CP*GP*GP*AP*AP*CP*GP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*CP*TP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*CP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... | Authors: | Ashworth, J, Duarte, C.M, Havranek, J.J, Sussman, D, Monnat, R.J, Stoddard, B.L, Baker, D. | Deposit date: | 2006-01-05 | Release date: | 2006-06-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Computational redesign of endonuclease DNA binding and cleavage specificity. Nature, 441, 2006
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2EXK
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![BU of 2exk by Molmil](/molmil-images/mine/2exk) | Structure of the family43 beta-Xylosidase E187G from geobacillus stearothermophilus in complex with xylobiose | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | Authors: | Brux, C, Niefind, K, Shallom-Shezifi, D, Shoham, Y, Schomburg, D. | Deposit date: | 2005-11-08 | Release date: | 2006-04-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Structure of an Inverting GH43 beta-Xylosidase from Geobacillus stearothermophilus with its Substrate Reveals the Role of the Three Catalytic Residues. J.Mol.Biol., 359, 2006
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2EXH
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![BU of 2exh by Molmil](/molmil-images/mine/2exh) | Structure of the family43 beta-Xylosidase from geobacillus stearothermophilus | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | Authors: | Brux, C, Niefind, K, Shallom-Shezifi, D, Yuval, S, Schomburg, D. | Deposit date: | 2005-11-08 | Release date: | 2006-04-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | The Structure of an Inverting GH43 beta-Xylosidase from Geobacillus stearothermophilus with its Substrate Reveals the Role of the Three Catalytic Residues. J.Mol.Biol., 359, 2006
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2EZ2
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![BU of 2ez2 by Molmil](/molmil-images/mine/2ez2) | Apo tyrosine phenol-lyase from Citrobacter freundii at pH 8.0 | Descriptor: | PHOSPHATE ION, POTASSIUM ION, Tyrosine phenol-lyase | Authors: | Milic, D, Matkovic-Calogovic, D, Demidkina, T.V, Antson, A.A. | Deposit date: | 2005-11-10 | Release date: | 2006-07-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structures of apo- and holo-tyrosine phenol-lyase reveal a catalytically critical closed conformation and suggest a mechanism for activation by K+ ions Biochemistry, 45, 2006
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2EJN
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![BU of 2ejn by Molmil](/molmil-images/mine/2ejn) | Structural characterization of the tetrameric form of the major cat allergen fel D 1 | Descriptor: | CALCIUM ION, Major allergen I polypeptide chain 1, chain 2 | Authors: | Kaiser, L, Velickovic, T.C, Badia-Martinez, D, Adedoyin, J, Thunberg, S, Hallen, D, Berndt, K, Gronlund, H, Gafvelin, G, van Hage, M, Achour, A. | Deposit date: | 2007-03-19 | Release date: | 2007-04-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Structural characterization of the tetrameric form of the major cat allergen Fel d 1 J.Mol.Biol., 370, 2007
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2FOF
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![BU of 2fof by Molmil](/molmil-images/mine/2fof) | Structure of porcine pancreatic elastase in 80% isopropanol | Descriptor: | CALCIUM ION, ISOPROPYL ALCOHOL, SULFATE ION, ... | Authors: | Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. | Deposit date: | 2006-01-13 | Release date: | 2006-04-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
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2FOB
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![BU of 2fob by Molmil](/molmil-images/mine/2fob) | Structure of porcine pancreatic elastase in 40/50/10 cyclohexane | Descriptor: | CALCIUM ION, ISOPROPYL ALCOHOL, SULFATE ION, ... | Authors: | Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. | Deposit date: | 2006-01-13 | Release date: | 2006-04-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
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2FOA
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![BU of 2foa by Molmil](/molmil-images/mine/2foa) | Structure of porcine pancreatic elastase in 40/50/10 % benzene | Descriptor: | CALCIUM ION, ISOPROPYL ALCOHOL, SULFATE ION, ... | Authors: | Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. | Deposit date: | 2006-01-13 | Release date: | 2006-04-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
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2FO9
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![BU of 2fo9 by Molmil](/molmil-images/mine/2fo9) | Structure of porcine pancreatic elastase in 95% acetone | Descriptor: | ACETONE, CALCIUM ION, SULFATE ION, ... | Authors: | Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. | Deposit date: | 2006-01-13 | Release date: | 2006-04-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
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2FOH
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![BU of 2foh by Molmil](/molmil-images/mine/2foh) | Structure of porcine pancreatic elastase in 40% trifluoroethanol | Descriptor: | CALCIUM ION, SULFATE ION, TRIFLUOROETHANOL, ... | Authors: | Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. | Deposit date: | 2006-01-13 | Release date: | 2006-04-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
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2FZF
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![BU of 2fzf by Molmil](/molmil-images/mine/2fzf) | Hypothetical Protein Pfu-1136390-001 From Pyrococcus furiosus | Descriptor: | hypothetical protein | Authors: | Fu, Z.-Q, Liu, Z.-J, Lee, D, Kelley, L, Chen, L, Tempel, W, Shah, N, Horanyi, P, Lee, H.S, Habel, J, Dillard, B.D, Nguyen, D, Chang, S.-H, Zhang, H, Chang, J, Sugar, F.J, Poole, F.L, Jenney Jr, F.E, Adams, M.W.W, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2006-02-09 | Release date: | 2006-02-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Hypothetical Protein Pfu-1136390-001 From Pyrococcus furiosus To be published
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2G3H
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![BU of 2g3h by Molmil](/molmil-images/mine/2g3h) | Cyanide Binding and Heme Cavity Conformational Transitions in Drosophila melanogaster Hexa-coordinate Hemoglobin | Descriptor: | CHLORIDE ION, CYANIDE ION, MAGNESIUM ION, ... | Authors: | de Sanctis, D, Ascenzi, P, Bocedi, A, Dewilde, S, Burmester, T, Hankeln, T, Moens, L, Bolognesi, M. | Deposit date: | 2006-02-20 | Release date: | 2006-10-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Cyanide binding and heme cavity conformational transitions in Drosophila melanogaster hexacoordinate hemoglobin. Biochemistry, 45, 2006
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7ORA
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![BU of 7ora by Molmil](/molmil-images/mine/7ora) | Crystal structure of the T478K mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-45 and COVOX-253 Fabs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COVOX-253 Fab heavy chain, ... | Authors: | Zhou, D, Ren, J, Stuart, D.I. | Deposit date: | 2021-06-04 | Release date: | 2021-07-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum. Cell, 184, 2021
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6WFZ
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![BU of 6wfz by Molmil](/molmil-images/mine/6wfz) | |
3V49
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![BU of 3v49 by Molmil](/molmil-images/mine/3v49) | Structure of ar lbd with activator peptide and sarm inhibitor 1 | Descriptor: | 4-[(4R)-4-(4-hydroxyphenyl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile, Androgen receptor, activator peptide, ... | Authors: | Nique, F, Hebbe, S, Peixoto, C, Annoot, D, Lefrancois, J.-M, Duval, E, Michoux, L, Triballeau, N, Lemoullec, J.-M, Mollat, P, Thauvin, M, Prange, T, Minet, D, Clement-Lacroix, P, Robin-Jagerschmidt, C, Fleury, D, Guedin, D, Deprez, P. | Deposit date: | 2011-12-14 | Release date: | 2012-09-05 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of diarylhydantoins as new selective androgen receptor modulators. J.Med.Chem., 55, 2012
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