6X4M
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![BU of 6x4m by Molmil](/molmil-images/mine/6x4m) | Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: tert-butyl [(2S)-1-{[(3S,17S)-2,16-dioxo-10,15-dioxa-1,21-diazatricyclo[15.3.1.1~5,9~]docosa-5(22),6,8-trien-3-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate (compound 3) | 分子名称: | Peptidyl-prolyl cis-trans isomerase A, tert-butyl [(2S)-1-{[(3S,17S)-2,16-dioxo-10,15-dioxa-1,21-diazatricyclo[15.3.1.1~5,9~]docosa-5(22),6,8-trien-3-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate | 著者 | Appleby, T.C, Paulsen, J.L, Schmitz, U, Shivakumar, D. | 登録日 | 2020-05-22 | 公開日 | 2020-06-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis. J.Chem.Inf.Model., 60, 2020
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2FY1
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![BU of 2fy1 by Molmil](/molmil-images/mine/2fy1) | A dual mode of RNA recognition by the RBMY protein | 分子名称: | RNA-binding motif protein, Y chromosome, family 1 member A1, ... | 著者 | Skrisovska, L, Bourgois, C, Stefl, R, Kister, L, Wenter, P, Elliot, D, Stevenin, J, Allain, F.H.T. | 登録日 | 2006-02-07 | 公開日 | 2007-02-06 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction. EMBO Rep., 8, 2007
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5KNZ
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![BU of 5knz by Molmil](/molmil-images/mine/5knz) | Human Islet Amyloid Polypeptide Segment 19-SGNNFGAILSS-29 with Early Onset S20G Mutation Determined by MicroED | 分子名称: | hIAPP(residues 19-29)S20G | 著者 | Krotee, P.A.L, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Shi, D, Nannenga, B.L, Hattne, J, Reyes, F.E, Gonen, T, Eisenberg, D.S. | 登録日 | 2016-06-28 | 公開日 | 2016-12-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.9 Å) | 主引用文献 | Atomic structures of fibrillar segments of hIAPP suggest tightly mated beta-sheets are important for cytotoxicity. Elife, 6, 2017
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6HVB
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![BU of 6hvb by Molmil](/molmil-images/mine/6hvb) | NMR structure of Urotensin Peptide Asp-c[Cys-Phe-(N-Me)Trp-Lys-Tyr-Cys]-Val in SDS solution | 分子名称: | Urotensin-2 | 著者 | Brancaccio, D, Carotenuto, A, Merlino, F, Billard, E, Yousif, A.M, Di Maro, S, Abate, L, Bellavita, R, D'Emmanuele di Villa Bianca, R, Santicioli, P, Marinelli, L, Novellino, E, Hebert, T.E, Lubell, W.D, Chatenet, D, Grieco, P. | 登録日 | 2018-10-10 | 公開日 | 2019-01-16 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides. J.Med.Chem., 62, 2019
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6X1Y
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![BU of 6x1y by Molmil](/molmil-images/mine/6x1y) | Mre11 dimer in complex with small molecule modulator PFMI | 分子名称: | (5Z)-5-[(3-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Nuclease SbcCD subunit D | 著者 | Arvai, A.S, Moiani, D, Tainer, J.A. | 登録日 | 2020-05-19 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response. Prog.Biophys.Mol.Biol., 163, 2021
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6X4Q
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![BU of 6x4q by Molmil](/molmil-images/mine/6x4q) | Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-14-cyclobutyl-2,11,17,17-tetramethyl-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 33) | 分子名称: | (2R,5S,11S,14S,18E)-14-cyclobutyl-2,11,17,17-tetramethyl-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone, Peptidyl-prolyl cis-trans isomerase A | 著者 | Appleby, T.C, Paulsen, J.L, Schmitz, U, Shivakumar, D. | 登録日 | 2020-05-22 | 公開日 | 2020-06-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis. J.Chem.Inf.Model., 60, 2020
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115D
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![BU of 115d by Molmil](/molmil-images/mine/115d) | ORDERED WATER STRUCTURE IN AN A-DNA OCTAMER AT 1.7 ANGSTROMS RESOLUTION | 分子名称: | DNA (5'-D(*GP*GP*(BRU)P*AP*(BRU)P*AP*CP*C)-3') | 著者 | Kennard, O, Cruse, W.B.T, Nachman, J, Prange, T, Shakked, Z, Rabinovich, D. | 登録日 | 1993-02-12 | 公開日 | 1993-07-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Ordered water structure in an A-DNA octamer at 1.7 A resolution. J.Biomol.Struct.Dyn., 3, 1986
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6I7D
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![BU of 6i7d by Molmil](/molmil-images/mine/6i7d) | Plasmodium falciparum Myosin A, post-rigor and rigor-like states | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Myosin-A | 著者 | Robert-Paganin, J, Auguin, D, Moussaoui, D, Jousset, G, Baum, J, Trybus, K.M, Houdusse, A. | 登録日 | 2018-11-16 | 公開日 | 2019-08-07 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism. Nat Commun, 10, 2019
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2FVV
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![BU of 2fvv by Molmil](/molmil-images/mine/2fvv) | Human Diphosphoinositol polyphosphate phosphohydrolase 1 | 分子名称: | CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Hallberg, B.M, Kursula, P, Ogg, D, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Flodin, S, Graslund, S, Hammarstrom, M, Hogbom, M, Holmberg-Schiavone, L, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, van den Berg, S, Weigelt, J, Persson, C, Structural Genomics Consortium (SGC) | 登録日 | 2006-01-31 | 公開日 | 2006-03-11 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Crystal structure of human diphosphoinositol phosphatase 1 Proteins, 77, 2009
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6ZGR
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![BU of 6zgr by Molmil](/molmil-images/mine/6zgr) | Crystal structure of a MFS transporter with bound 1-hydroxynaphthalene-2-carboxylic acid at 2.67 Angstroem resolution | 分子名称: | 1-hydroxynaphthalene-2-carboxylic acid, L-lactate transporter | 著者 | Kalbermatter, D, Bosshart, P, Bonetti, S, Fotiadis, D. | 登録日 | 2020-06-19 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | The making of a potent L-lactate transport inhibitor Commun Chem, 4, 2021
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6ZGU
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![BU of 6zgu by Molmil](/molmil-images/mine/6zgu) | Crystal structure of a MFS transporter with bound 3-(2-methylphenyl)propanoic acid at 2.41 Angstroem resolution | 分子名称: | 3-(2-methylphenyl)propanoic acid, L-lactate transporter | 著者 | Kalbermatter, D, Bosshart, P, Bonetti, S, Fotiadis, D. | 登録日 | 2020-06-19 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | The making of a potent L-lactate transport inhibitor Commun Chem, 4, 2021
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6ZGT
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![BU of 6zgt by Molmil](/molmil-images/mine/6zgt) | Crystal structure of a MFS transporter with bound 2-naphthoic acid at 2.39 Angstroem resolution | 分子名称: | L-lactate transporter, naphthalene-2-carboxylic acid | 著者 | Kalbermatter, D, Bosshart, P, Bonetti, S, Fotiadis, D. | 登録日 | 2020-06-19 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | The making of a potent L-lactate transport inhibitor Commun Chem, 4, 2021
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6ZGS
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![BU of 6zgs by Molmil](/molmil-images/mine/6zgs) | Crystal structure of a MFS transporter with bound 3-phenylpropanoic acid at 2.39 Angstroem resolution | 分子名称: | HYDROCINNAMIC ACID, L-lactate transporter | 著者 | Kalbermatter, D, Bosshart, P, Bonetti, S, Fotiadis, D. | 登録日 | 2020-06-19 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | 主引用文献 | The making of a potent L-lactate transport inhibitor Commun Chem, 4, 2021
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5HDI
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![BU of 5hdi by Molmil](/molmil-images/mine/5hdi) | Structural characterization of CYP144A1, a Mycobacterium tuberculosis cytochrome P450 | 分子名称: | Cytochrome P450 144, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Chenge, J, Driscoll, M.D, McLean, K.J, Munro, A.W, Leys, D. | 登録日 | 2016-01-05 | 公開日 | 2016-05-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis. Sci Rep, 6, 2016
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6X0P
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![BU of 6x0p by Molmil](/molmil-images/mine/6x0p) | Ash1L SET domain Q2265A mutant in complex with AS-5 | 分子名称: | 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide, Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ... | 著者 | Rogawski, D.S, Li, H, Borkin, D, Cierpicki, T, Grembecka, J. | 登録日 | 2020-05-17 | 公開日 | 2021-04-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun, 12, 2021
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5HIA
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![BU of 5hia by Molmil](/molmil-images/mine/5hia) | Human hypoxanthine-guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine | 分子名称: | Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-y l]-3-oxidanylidene-propyl]phosphonic acid | 著者 | Guddat, L.W, Keough, D.T, Rejman, D. | 登録日 | 2016-01-11 | 公開日 | 2017-01-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.773 Å) | 主引用文献 | Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics. ACS Chem. Biol., 2017
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5HQX
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![BU of 5hqx by Molmil](/molmil-images/mine/5hqx) | Crystal structure of maize cytokinin oxidase/dehydrogenase 4 (ZmCKO4) in complex with phenylurea inhibitor HETDZ | 分子名称: | 1-[2-(2-hydroxyethyl)phenyl]-3-(1,2,3-thiadiazol-5-yl)urea, Cytokinin dehydrogenase 4, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Kopecny, D, Koncitikova, R, Briozzo, P. | 登録日 | 2016-01-22 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Novel thidiazuron-derived inhibitors of cytokinin oxidase/dehydrogenase. Plant Mol.Biol., 92, 2016
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7OY2
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![BU of 7oy2 by Molmil](/molmil-images/mine/7oy2) | High resolution structure of cytochrome bd-II oxidase from E. coli | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[(2~{E},6~{E},10~{Z},14~{E},18~{E},22~{E},26~{E})-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaenyl]naphthalene-1,4-dione, CARDIOLIPIN, ... | 著者 | Grund, T.N, Wu, D, Bald, D, Michel, H, Safarian, S. | 登録日 | 2021-06-23 | 公開日 | 2021-12-15 | 最終更新日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (2.06 Å) | 主引用文献 | Mechanistic and structural diversity between cytochrome bd isoforms of Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
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8T5F
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![BU of 8t5f by Molmil](/molmil-images/mine/8t5f) | De novo design of high-affinity protein binders to bioactive helical peptides | 分子名称: | Parathyroid hormone | 著者 | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | 登録日 | 2023-06-13 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | De novo design of high-affinity binders of bioactive helical peptides. Nature, 626, 2024
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4PL5
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![BU of 4pl5 by Molmil](/molmil-images/mine/4pl5) | Crystal structure of murine IRE1 in complex with OICR573 inhibitor | 分子名称: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 3-methoxy-5-methyl-4'-(morpholin-4-yl)biphenyl-4-ol, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Sanches, M, Duffy, N, Talukdar, M, Thevakumaran, N, Chiovitti, D, Al-awar, R, Patterson, J.B, Sicheri, F. | 登録日 | 2014-05-16 | 公開日 | 2014-09-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun, 5, 2014
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8T5E
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![BU of 8t5e by Molmil](/molmil-images/mine/8t5e) | De novo design of high-affinity protein binders to bioactive helical peptides | 分子名称: | Bcl-2-like protein 11, Bim_fulldiff | 著者 | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | 登録日 | 2023-06-13 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | De novo design of high-affinity binders of bioactive helical peptides. Nature, 626, 2024
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6RQP
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![BU of 6rqp by Molmil](/molmil-images/mine/6rqp) | Steady-state-SMX dark state structure of bacteriorhodopsin | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, Bacteriorhodopsin, ... | 著者 | Weinert, T, Skopintsev, P, James, D, Kekilli, D, Furrer, A, Bruenle, S, Mous, S, Nogly, P, Standfuss, J. | 登録日 | 2019-05-16 | 公開日 | 2019-07-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography. Science, 365, 2019
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1AH2
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![BU of 1ah2 by Molmil](/molmil-images/mine/1ah2) | SERINE PROTEASE PB92 FROM BACILLUS ALCALOPHILUS, NMR, 18 STRUCTURES | 分子名称: | SERINE PROTEASE PB92 | 著者 | Boelens, R, Schipper, D, Martin, J.R, Karimi-Nejad, Y, Mulder, F, Zwan, J.V.D, Mariani, M. | 登録日 | 1997-04-11 | 公開日 | 1998-04-15 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of serine protease PB92 from Bacillus alcalophilus presents a rigid fold with a flexible substrate-binding site. Structure, 5, 1997
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2G62
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![BU of 2g62 by Molmil](/molmil-images/mine/2g62) | Crystal structure of human PTPA | 分子名称: | GLYCEROL, SULFATE ION, protein phosphatase 2A, ... | 著者 | Magnusdottir, A, Stenmark, P, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Hogbom, M, Holmberg Schiavone, L, Kotenyova, T, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Wallden, K, Weigelt, J, Nordlund, P. | 登録日 | 2006-02-24 | 公開日 | 2006-04-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions. J.Biol.Chem., 281, 2006
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5HNR
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![BU of 5hnr by Molmil](/molmil-images/mine/5hnr) | The X-ray structure of octameric human native 5-aminolaevulinic acid dehydratase. | 分子名称: | DELTA-AMINO VALERIC ACID, Delta-aminolevulinic acid dehydratase, SULFATE ION, ... | 著者 | Mills-Davies, N.L, Thompson, D, Shoolingin-Jordan, P.M, Erskine, P.T, Cooper, J.B. | 登録日 | 2016-01-18 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Structural studies of substrate and product complexes of 5-aminolaevulinic acid dehydratase from humans, Escherichia coli and the hyperthermophile Pyrobaculum calidifontis. Acta Crystallogr D Struct Biol, 73, 2017
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